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| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | RBPJ | Recombination signal binding protein for immunoglobulin kappa J region. (488 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (721 aa) |
| | SNW1 | SNW domain containing 1. (598 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | CD247 | CD247 molecule. (165 aa) |
| | CD3D | CD3d molecule. (171 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | HLA-DRA | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa) |
| | CD44 | CD44 molecule (Indian blood group). (742 aa) |
| | ENSCATP00000000012 | Protein kinase domain-containing protein. (231 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | LOC105575603 | Ig-like domain-containing protein. (284 aa) |
| | TYK2 | Tyrosine-protein kinase. (1164 aa) |
| | LOC105574081 | Ig-like domain-containing protein. (132 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | ENSCATP00000001099 | Ig-like domain-containing protein. (272 aa) |
| | LOC105595720 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | ISG15 | ISG15 ubiquitin like modifier. (165 aa) |
| | ENSCATP00000001452 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa) |
| | HLA-F | Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (439 aa) |
| | LOC105576630 | Ig-like domain-containing protein; Belongs to the MHC class I family. (403 aa) |
| | SYK | Non-specific protein-tyrosine kinase. (637 aa) |
| | ENSCATP00000002136 | Ig-like domain-containing protein; Belongs to the MHC class I family. (331 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | C7orf31 | Chromosome 7 open reading frame 31. (590 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (517 aa) |
| | OSBPL2 | Oxysterol-binding protein; Belongs to the OSBP family. (480 aa) |
| | ENSCATP00000003553 | MHC_I-like_Ag-recog domain-containing protein. (170 aa) |
| | POLK | DNA polymerase kappa. (845 aa) |
| | SEM1-2 | Uncharacterized protein. (89 aa) |
| | ENSCATP00000004066 | Uncharacterized protein. (189 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (203 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | ENSCATP00000004934 | ATPase_AAA_core domain-containing protein; Belongs to the AAA ATPase family. (177 aa) |
| | RUNX3 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa) |
| | ENSCATP00000005024 | Ig-like domain-containing protein. (150 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (416 aa) |
| | RELB | RELB proto-oncogene, NF-kB subunit. (574 aa) |
| | LOC105574050 | Ig-like domain-containing protein. (138 aa) |
| | RB1 | RB transcriptional corepressor 1. (926 aa) |
| | IFNAR2 | Interfer-bind domain-containing protein. (419 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (571 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | VIM | Vimentin; Belongs to the intermediate filament family. (466 aa) |
| | LOC105588083 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | ENSCATP00000006715 | Ig-like domain-containing protein. (140 aa) |
| | PSMC3 | AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa) |
| | LOC105589984 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | JAK3 | Tyrosine-protein kinase. (1124 aa) |
| | TLR2 | Toll-like receptor. (784 aa) |
| | IFNA6 | Interferon alpha 6. (190 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (324 aa) |
| | LOC105575006 | Ig-like domain-containing protein. (263 aa) |
| | HLA-DPA1 | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa) |
| | TAPBP | TAP binding protein. (504 aa) |
| | CD40 | CD40 molecule. (278 aa) |
| | NFKBIE | NFKB inhibitor epsilon. (484 aa) |
| | ENSCATP00000009380 | Ig-like domain-containing protein; Belongs to the MHC class I family. (365 aa) |
| | ENSCATP00000009482 | Ig-like domain-containing protein. (139 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | ENSCATP00000010103 | Ig-like domain-containing protein. (273 aa) |
| | LOC105577130 | Ig-like domain-containing protein. (133 aa) |
| | CASP3 | Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | CR2 | Complement C3d receptor 2. (1108 aa) |
| | ENSCATP00000010732 | CSN8_PSD8_EIF3K domain-containing protein. (249 aa) |
| | LOC105575920 | Ig-like domain-containing protein. (140 aa) |
| | ITGAL | Integrin subunit alpha L; Belongs to the integrin alpha chain family. (1155 aa) |
| | LOC105576712 | Ig-like domain-containing protein; Belongs to the MHC class I family. (392 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | FCER2 | Fc fragment of IgE receptor II. (321 aa) |
| | ENSCATP00000011714 | Uncharacterized protein. (288 aa) |
| | ENSCATP00000011745 | AAA domain-containing protein. (410 aa) |
| | TRADD | TNFRSF1A associated via death domain. (308 aa) |
| | ENSCATP00000012040 | IGc1 domain-containing protein; Belongs to the MHC class I family. (392 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (442 aa) |
| | HLA-DQB1 | Major histocompatibility complex, class II, DQ beta 1. (284 aa) |
| | LYN | Tyrosine-protein kinase. (507 aa) |
| | RAC1 | Uncharacterized protein. (212 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa) |
| | ENSCATP00000012901 | MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (217 aa) |
| | ENSCATP00000012908 | Ig-like domain-containing protein. (144 aa) |
| | ENSCATP00000012945 | Protein kinase domain-containing protein. (101 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | HLA-DMA | Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) |
| | ENSCATP00000013364 | Ig-like domain-containing protein; Belongs to the MHC class I family. (357 aa) |
| | PSMD4 | Proteasome 26S subunit, non-ATPase 4. (363 aa) |
| | PSMC6 | AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa) |
| | USP7 | Uncharacterized protein; Belongs to the peptidase C19 family. (1093 aa) |
| | LOC105575604 | Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa) |
| | ENSCATP00000014541 | Prot_ATP_ID_OB domain-containing protein. (172 aa) |
| | ENSCATP00000014620 | SKIP_SNW domain-containing protein. (480 aa) |
| | ENSCATP00000014761 | Ig-like domain-containing protein. (262 aa) |
| | IRF7 | Interferon regulatory factor 7. (517 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (541 aa) |
| | ENSCATP00000015134 | Ig-like domain-containing protein. (173 aa) |
| | ENSCATP00000015253 | AAA domain-containing protein. (373 aa) |
| | ENSCATP00000015421 | Ig-like domain-containing protein. (140 aa) |
| | RBPJL | Recombination signal binding protein for immunoglobulin kappa J region like. (522 aa) |
| | ENSCATP00000016334 | Uncharacterized protein. (338 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | ENSCATP00000016481 | AAA domain-containing protein. (370 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa) |
| | CD58 | CD58 molecule. (250 aa) |
| | BID | BH3 interacting domain death agonist. (244 aa) |
| | STAT3 | Signal transducer and activator of transcription. (777 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | ENSCATP00000018187 | Ig-like domain-containing protein. (265 aa) |
| | PSMD12 | Proteasome 26S subunit, non-ATPase 12. (456 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (612 aa) |
| | CALR | Calreticulin. (389 aa) |
| | LOC105575605 | Ig-like domain-containing protein. (263 aa) |
| | ENSCATP00000019483 | MHC_I-like_Ag-recog domain-containing protein. (80 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (900 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | ENSCATP00000020093 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (433 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1236 aa) |
| | ENSCATP00000020357 | AAA domain-containing protein; Belongs to the AAA ATPase family. (414 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1273 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | TAP1 | Transporter 1, ATP binding cassette subfamily B member. (808 aa) |
| | PSMC5 | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa) |
| | ENSCATP00000020536 | MHC_I-like_Ag-recog domain-containing protein. (176 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | SKP2 | S-phase kinase associated protein 2. (437 aa) |
| | ENSCATP00000021172 | Uncharacterized protein. (278 aa) |
| | LOC105576725 | Ig-like domain-containing protein. (283 aa) |
| | CD19 | CD19 molecule. (531 aa) |
| | CIR1 | Corepressor interacting with RBPJ, 1. (375 aa) |
| | LOC105600307 | Ig-like domain-containing protein. (268 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (326 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3. (1088 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | SAP30 | Sin3A associated protein 30. (220 aa) |
| | PIK3R2 | Uncharacterized protein. (624 aa) |
| | ENTPD8 | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (520 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa) |
| | ENTPD1 | Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (517 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | ENSCATP00000024481 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa) |
| | CXCL10 | C-X-C motif chemokine. (98 aa) |
| | ENSCATP00000024633 | MHC_I-like_Ag-recog domain-containing protein. (147 aa) |
| | HLA-DOA | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (298 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | LOC105575013 | Ig-like domain-containing protein. (273 aa) |
| | LOC105576724 | Ig-like domain-containing protein. (283 aa) |
| | ICAM1 | Intercellular adhesion molecule 1. (532 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (515 aa) |
| | SAP30L | SAP30 like. (191 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | TRAC | T cell receptor alpha constant. (110 aa) |
| | LOC105576705 | Ig-like domain-containing protein; Belongs to the MHC class I family. (368 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (947 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | ENSCATP00000028696 | Ig-like domain-containing protein. (133 aa) |
| | PSMD8 | Proteasome 26S subunit, non-ATPase 8. (350 aa) |
| | CC2D2A | Coiled-coil and C2 domain containing 2A. (1627 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | HLA-DPB1 | Major histocompatibility complex, class II, DP beta 1. (258 aa) |
| | ENSCATP00000030160 | Ig-like domain-containing protein; Belongs to the MHC class I family. (349 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (489 aa) |
| | PSMC1 | Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa) |
| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (452 aa) |
| | ENSCATP00000030836 | Uncharacterized protein. (149 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | TAP2 | Transporter 2, ATP binding cassette subfamily B member. (711 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | STAT1 | Signal transducer and activator of transcription. (780 aa) |
| | ENSCATP00000032552 | Cytochrome c domain-containing protein; Belongs to the cytochrome c family. (109 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (160 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | PSMC2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (465 aa) |
| | ENSCATP00000033254 | Ig-like domain-containing protein; Belongs to the MHC class I family. (339 aa) |
| | E2F3 | E2F transcription factor 3. (467 aa) |
| | LOC105600305 | Ig-like domain-containing protein; Belongs to the MHC class II family. (219 aa) |
| | ENSCATP00000034214 | Ig-like domain-containing protein; Belongs to the MHC class I family. (329 aa) |
| | IRF3 | Interferon regulatory factor 3. (422 aa) |
| | STAT2 | Signal transducer and activator of transcription. (852 aa) |
| | DDX58 | DExD/H-box helicase 58. (925 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | ENSCATP00000034742 | JAB_MPN domain-containing protein. (166 aa) |
| | ENSCATP00000034919 | Ig-like domain-containing protein. (264 aa) |
| | BLNK | B cell linker. (456 aa) |
| | PDIA3 | Protein disulfide isomerase family A member 3. (451 aa) |
| | LOC105583891 | Ig-like domain-containing protein. (339 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (550 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (718 aa) |
| | ENSCATP00000036475 | Uncharacterized protein. (59 aa) |
| | PSMD3 | Proteasome 26S subunit, non-ATPase 3. (534 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) |
| | JAK1 | Tyrosine-protein kinase. (1159 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (214 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (790 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (292 aa) |
| | ENSCATP00000037470 | AAA domain-containing protein. (389 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa) |
| | ENSCATP00000037900 | DUF5523 domain-containing protein. (1036 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | ENSCATP00000038453 | Uncharacterized protein; Belongs to the peptidase C14A family. (262 aa) |
| | ENSCATP00000038535 | E2F_CC-MB domain-containing protein. (193 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | NEDD4 | NEDD4 E3 ubiquitin protein ligase. (1319 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (379 aa) |
| | CD3G | CD3g molecule. (181 aa) |
| | TRBV10-1 | T cell receptor beta variable 10-1(gene/pseudogene). (131 aa) |
| | NCOR2 | Nuclear receptor corepressor 2. (2510 aa) |
| | TRBV11-1 | T cell receptor beta variable 11-1. (142 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (315 aa) |
| | ADRM1 | Adhesion regulating molecule 1. (407 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | FAS | Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (331 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | LOC105571593 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | ENSCATP00000041490 | AAA domain-containing protein; Belongs to the AAA ATPase family. (199 aa) |
| | ENSCATP00000041581 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa) |
| | CD3E | CD3e molecule. (198 aa) |
| | IRF9 | Uncharacterized protein. (195 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) |
| | SIN3B | SIN3 transcription regulator family member B. (1159 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | HLA-E | Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (356 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (586 aa) |
| | ENSCATP00000042953 | IRF tryptophan pentad repeat domain-containing protein. (50 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
