STRINGSTRING
ENSCATP00000002218 ENSCATP00000002218 SMAD3 SMAD3 MAPK8 MAPK8 C7orf31 C7orf31 RALGDS RALGDS ENSCATP00000003016 ENSCATP00000003016 LOC105575634 LOC105575634 POLK POLK SOS1 SOS1 ENSCATP00000004066 ENSCATP00000004066 BAX BAX ERAS ERAS CDKN1A CDKN1A RHOA RHOA CASP9 CASP9 LOC105588083 LOC105588083 AKT1 AKT1 LOC105589984 LOC105589984 DCC DCC TGFB3 TGFB3 RALA RALA TGFB1 TGFB1 RPS6KB1 RPS6KB1 CASP3 CASP3 ENSCATP00000010452 ENSCATP00000010452 TGFBR1 TGFBR1 RAC3 RAC3 MAPK3 MAPK3 KRAS KRAS TGFB2 TGFB2 RAC1 RAC1 ENSCATP00000000152 ENSCATP00000000152 SMAD2 SMAD2 LOC105595720 LOC105595720 ENSCATP00000001452 ENSCATP00000001452 ENSCATP00000001613 ENSCATP00000001613 ARAF ARAF RHOC RHOC FOS FOS BBC3 BBC3 ENSCATP00000043907 ENSCATP00000043907 TCF7 TCF7 BCL2 BCL2 GRB2 GRB2 MAPK10 MAPK10 ENSCATP00000041581 ENSCATP00000041581 TGFA TGFA BCL2L11 BCL2L11 LOC105571593 LOC105571593 APC2 APC2 SOS2 SOS2 ENSCATP00000038453 ENSCATP00000038453 PIK3CD PIK3CD PMAIP1 PMAIP1 ENSCATP00000037667 ENSCATP00000037667 EGF EGF EREG EREG GADD45G GADD45G SMAD4 SMAD4 MSH2 MSH2 NRAS NRAS MLH1 MLH1 GADD45A GADD45A MTOR MTOR CCND1 CCND1 RAC2 RAC2 TGFBR2 TGFBR2 EGFR EGFR TCF7L1 TCF7L1 GADD45B GADD45B ENSCATP00000032552 ENSCATP00000032552 RALB RALB AKT2 AKT2 TP53 TP53 AXIN1 AXIN1 BAK1 BAK1 RGL4 RGL4 APPL1 APPL1 ENSCATP00000030673 ENSCATP00000030673 PPP1R14B PPP1R14B MAP2K1 MAP2K1 MYC MYC PIK3R1 PIK3R1 DDB2 DDB2 PIK3R3 PIK3R3 CSDE1 CSDE1 PIK3CA PIK3CA EPGN EPGN RAF1 RAF1 ENSCATP00000024481 ENSCATP00000024481 ENSCATP00000024396 ENSCATP00000024396 PIK3CB PIK3CB PIK3R2 PIK3R2 AREG AREG ENSCATP00000023486 ENSCATP00000023486 LEF1 LEF1 LOC105575857 LOC105575857 GSK3B GSK3B ENSCATP00000022023 ENSCATP00000022023 CTNNB1 CTNNB1 BRAF BRAF MSH3 MSH3 MAPK9 MAPK9 AXIN2 AXIN2 AKT3 AKT3 LOC105572981 LOC105572981 BAD BAD RGL4-2 RGL4-2 BIRC5 BIRC5 TCF7L2 TCF7L2 MAPK1 MAPK1 HRAS HRAS RPS6KB2 RPS6KB2 MAP2K2 MAP2K2 APC APC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCATP00000002218Uncharacterized protein. (228 aa)
SMAD3Mothers against decapentaplegic homolog. (429 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
RALGDSUncharacterized protein. (912 aa)
ENSCATP00000003016Ras-GEF domain-containing protein. (500 aa)
LOC105575634Ras-GEF domain-containing protein. (577 aa)
POLKDNA polymerase kappa. (845 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
ENSCATP00000004066Uncharacterized protein. (189 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
ERASES cell expressed Ras. (233 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
RHOARas homolog family member A. (193 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
LOC105588083Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC105589984Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
DCCDCC netrin 1 receptor. (1447 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RALARAS like proto-oncogene A. (206 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
ENSCATP00000010452Uncharacterized protein. (596 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
RAC3Rac family small GTPase 3. (205 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RAC1Uncharacterized protein. (212 aa)
ENSCATP00000000152Uncharacterized protein. (64 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
LOC105595720Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSCATP00000001452Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa)
ENSCATP00000001613Ras-GEF domain-containing protein. (602 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
RHOCRas homolog family member C. (193 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
BBC3BCL2 binding component 3. (261 aa)
ENSCATP00000043907Uncharacterized protein. (193 aa)
TCF7Transcription factor 7. (481 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
ENSCATP00000041581Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
TGFATransforming growth factor alpha. (166 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
LOC105571593Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
ENSCATP00000038453Uncharacterized protein; Belongs to the peptidase C14A family. (262 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PMAIP1Uncharacterized protein. (133 aa)
ENSCATP00000037667Protein kinase domain-containing protein. (365 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
EREGEpiregulin. (169 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MLH1MutL homolog 1. (756 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
RAC2Rac family small GTPase 2. (192 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
ENSCATP00000032552Cytochrome c domain-containing protein; Belongs to the cytochrome c family. (109 aa)
RALBRAS like proto-oncogene B. (212 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
AXIN1Axin 1. (867 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
RGL4Ral guanine nucleotide dissociation stimulator like 4. (532 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (715 aa)
ENSCATP00000030673Uncharacterized protein. (652 aa)
PPP1R14BUncharacterized protein. (207 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
EPGNEpithelial mitogen. (154 aa)
RAF1Uncharacterized protein. (668 aa)
ENSCATP00000024481Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa)
ENSCATP00000024396DNA_MISMATCH_REPAIR_2 domain-containing protein. (311 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PIK3R2Uncharacterized protein. (624 aa)
AREGAmphiregulin. (274 aa)
ENSCATP00000023486PWWP domain-containing protein. (150 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
LOC105575857Ras-GEF domain-containing protein. (591 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
ENSCATP00000022023Ras-GEF domain-containing protein. (466 aa)
CTNNB1Catenin beta 1. (781 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1135 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
AXIN2Axin 2. (843 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC105572981Uncharacterized protein. (132 aa)
BADBCL2 associated agonist of cell death. (167 aa)
RGL4-2Ras-GEF domain-containing protein. (560 aa)
BIRC5Uncharacterized protein. (147 aa)
TCF7L2Transcription factor 7 like 2. (666 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
APCAPC regulator of WNT signaling pathway. (2861 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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