STRINGSTRING
PLD1 PLD1 ENSCATP00000045875 ENSCATP00000045875 NFKB1 NFKB1 ENSCATP00000043907 ENSCATP00000043907 ENSCATP00000042801 ENSCATP00000042801 CHUK CHUK MAPK10 MAPK10 TGFA TGFA ENSCATP00000038535 ENSCATP00000038535 PIK3CD PIK3CD ENSCATP00000037667 ENSCATP00000037667 EGF EGF JAK1 JAK1 GADD45G GADD45G SMAD4 SMAD4 RELA RELA GADD45A GADD45A MTOR MTOR CCND1 CCND1 RAC2 RAC2 TGFBR2 TGFBR2 E2F3 E2F3 EGFR EGFR E2F1 E2F1 GADD45B GADD45B STAT1 STAT1 RALBP1 RALBP1 RALB RALB AKT2 AKT2 TP53 TP53 PLD2 PLD2 BAK1 BAK1 RGL4 RGL4 ENSCATP00000030673 ENSCATP00000030673 PPP1R14B PPP1R14B MAP2K1 MAP2K1 PIK3R1 PIK3R1 DDB2 DDB2 PIK3R3 PIK3R3 PIK3CA PIK3CA CDK6 CDK6 RAF1 RAF1 PIK3CB PIK3CB PIK3R2 PIK3R2 LOC105575857 LOC105575857 ENSCATP00000022023 ENSCATP00000022023 CDC42 CDC42 BCL2L1 BCL2L1 BRAF BRAF MAPK9 MAPK9 RAD51 RAD51 AKT3 AKT3 LOC105572981 LOC105572981 IKBKB IKBKB BAD BAD RGL4-2 RGL4-2 STAT3 STAT3 ENSCATP00000017084 ENSCATP00000017084 MAPK1 MAPK1 BRCA2 BRCA2 RPS6KB2 RPS6KB2 IKBKG IKBKG ENSCATP00000013162 ENSCATP00000013162 ENSCATP00000012945 ENSCATP00000012945 ARAF ARAF RAC1 RAC1 TGFB2 TGFB2 VEGFA VEGFA KRAS KRAS E2F2 E2F2 MAPK3 MAPK3 RAC3 RAC3 TGFBR1 TGFBR1 ENSCATP00000010452 ENSCATP00000010452 RPS6KB1 RPS6KB1 TGFB1 TGFB1 RALA RALA ARHGEF6 ARHGEF6 TGFB3 TGFB3 ERBB2 ERBB2 AKT1 AKT1 RB1 RB1 CASP9 CASP9 CDK4 CDK4 CDKN1A CDKN1A ERAS ERAS ENSCATP00000004469 ENSCATP00000004469 LOC105571986 LOC105571986 BAX BAX ENSCATP00000004066 ENSCATP00000004066 POLK POLK LOC105575634 LOC105575634 ENSCATP00000003016 ENSCATP00000003016 RALGDS RALGDS MAPK8 MAPK8 SMAD3 SMAD3 CDKN2A CDKN2A ENSCATP00000001613 ENSCATP00000001613 SMAD2 SMAD2 ENSCATP00000000152 ENSCATP00000000152
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLD1Phospholipase. (1067 aa)
ENSCATP00000045875Rho-GAP domain-containing protein. (525 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
ENSCATP00000043907Uncharacterized protein. (193 aa)
ENSCATP00000042801Uncharacterized protein. (136 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
TGFATransforming growth factor alpha. (166 aa)
ENSCATP00000038535E2F_CC-MB domain-containing protein. (193 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSCATP00000037667Protein kinase domain-containing protein. (365 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
RAC2Rac family small GTPase 2. (192 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
E2F3E2F transcription factor 3. (467 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
E2F1E2F transcription factor 1. (437 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
RALBP1RalA binding protein 1. (655 aa)
RALBRAS like proto-oncogene B. (212 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
PLD2Phospholipase. (933 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
RGL4Ral guanine nucleotide dissociation stimulator like 4. (532 aa)
ENSCATP00000030673Uncharacterized protein. (652 aa)
PPP1R14BUncharacterized protein. (207 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RAF1Uncharacterized protein. (668 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PIK3R2Uncharacterized protein. (624 aa)
LOC105575857Ras-GEF domain-containing protein. (591 aa)
ENSCATP00000022023Ras-GEF domain-containing protein. (466 aa)
CDC42Uncharacterized protein. (191 aa)
BCL2L1BCL2 like 1. (233 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (309 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC105572981Uncharacterized protein. (132 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
BADBCL2 associated agonist of cell death. (167 aa)
RGL4-2Ras-GEF domain-containing protein. (560 aa)
STAT3Signal transducer and activator of transcription. (777 aa)
ENSCATP00000017084Uncharacterized protein. (185 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
ENSCATP00000013162Uncharacterized protein. (173 aa)
ENSCATP00000012945Protein kinase domain-containing protein. (101 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
RAC1Uncharacterized protein. (212 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (409 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
E2F2E2F transcription factor 2. (437 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
RAC3Rac family small GTPase 3. (205 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ENSCATP00000010452Uncharacterized protein. (596 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
RALARAS like proto-oncogene A. (206 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RB1RB transcriptional corepressor 1. (926 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ERASES cell expressed Ras. (233 aa)
ENSCATP00000004469Uncharacterized protein. (191 aa)
LOC105571986Uncharacterized protein. (189 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
ENSCATP00000004066Uncharacterized protein. (189 aa)
POLKDNA polymerase kappa. (845 aa)
LOC105575634Ras-GEF domain-containing protein. (577 aa)
ENSCATP00000003016Ras-GEF domain-containing protein. (500 aa)
RALGDSUncharacterized protein. (912 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
SMAD3Mothers against decapentaplegic homolog. (429 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
ENSCATP00000001613Ras-GEF domain-containing protein. (602 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ENSCATP00000000152Uncharacterized protein. (64 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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