STRINGSTRING
AKT3 AKT3 CTNNA2 CTNNA2 LOC105572981 LOC105572981 BAD BAD PDPK1 PDPK1 ENSCATP00000017436 ENSCATP00000017436 ELK1 ELK1 TCF7L2 TCF7L2 MAPK1 MAPK1 ENSCATP00000014838 ENSCATP00000014838 HRAS HRAS MAP2K2 MAP2K2 PTEN PTEN APC APC ARAF ARAF KRAS KRAS POLK POLK ENSCATP00000000560 ENSCATP00000000560 ENSCATP00000000152 ENSCATP00000000152 MAPK3 MAPK3 ENSCATP00000010452 ENSCATP00000010452 ERBB2 ERBB2 AKT1 AKT1 CASP9 CASP9 ENSCATP00000004894 ENSCATP00000004894 CDKN1A CDKN1A ERAS ERAS BAX BAX ENSCATP00000004066 ENSCATP00000004066 SOS1 SOS1 TPTE2 TPTE2 CTNNA3 CTNNA3 ENSCATP00000044372 ENSCATP00000044372 TCF7 TCF7 GRB2 GRB2 APC2 APC2 SOS2 SOS2 PIK3CD PIK3CD ENSCATP00000037667 ENSCATP00000037667 ILK ILK CDH1 CDH1 EGF EGF GADD45G GADD45G NRAS NRAS MLH1 MLH1 GADD45A GADD45A CCND1 CCND1 CTNNA1 CTNNA1 EGFR EGFR TCF7L1 TCF7L1 GADD45B GADD45B FOXO3 FOXO3 AKT2 AKT2 TP53 TP53 AXIN1 AXIN1 BAK1 BAK1 ENSCATP00000030673 ENSCATP00000030673 PPP1R14B PPP1R14B MAP2K1 MAP2K1 MYC MYC PIK3R1 PIK3R1 DDB2 DDB2 PIK3R3 PIK3R3 CSDE1 CSDE1 PIK3CA PIK3CA RAF1 RAF1 PIK3CB PIK3CB PIK3R2 PIK3R2 LEF1 LEF1 GSK3B GSK3B CTNNB1 CTNNB1 BRAF BRAF AXIN2 AXIN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CTNNA2Catenin alpha 2. (953 aa)
LOC105572981Uncharacterized protein. (132 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (534 aa)
ENSCATP00000017436ETS domain-containing protein. (394 aa)
ELK1ETS domain-containing protein. (428 aa)
TCF7L2Transcription factor 7 like 2. (666 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ENSCATP00000014838ETS domain-containing protein. (418 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
APCAPC regulator of WNT signaling pathway. (2861 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
POLKDNA polymerase kappa. (845 aa)
ENSCATP00000000560C2 tensin-type domain-containing protein. (165 aa)
ENSCATP00000000152Uncharacterized protein. (64 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
ENSCATP00000010452Uncharacterized protein. (596 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
ENSCATP00000004894ETS domain-containing protein. (421 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ERASES cell expressed Ras. (233 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
ENSCATP00000004066Uncharacterized protein. (189 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
TPTE2Uncharacterized protein. (550 aa)
CTNNA3Catenin alpha 3. (895 aa)
ENSCATP00000044372Uncharacterized protein. (731 aa)
TCF7Transcription factor 7. (481 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSCATP00000037667Protein kinase domain-containing protein. (365 aa)
ILKIntegrin linked kinase. (526 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MLH1MutL homolog 1. (756 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CTNNA1Catenin alpha 1. (906 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
FOXO3Forkhead box O3. (672 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
AXIN1Axin 1. (867 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ENSCATP00000030673Uncharacterized protein. (652 aa)
PPP1R14BUncharacterized protein. (207 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
RAF1Uncharacterized protein. (668 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PIK3R2Uncharacterized protein. (624 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
CTNNB1Catenin beta 1. (781 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
AXIN2Axin 2. (843 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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