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PLCG1 PLCG1 CAMK2A CAMK2A ARSI ARSI PIK3R2 PIK3R2 PIK3CB PIK3CB LOC105585293 LOC105585293 RAF1 RAF1 CDK6 CDK6 CAMK2D CAMK2D CALM3 CALM3 PIK3CA PIK3CA SHC1 SHC1 CSDE1 CSDE1 PIK3R3 PIK3R3 DDB2 DDB2 PIK3R1 PIK3R1 MAP2K1 MAP2K1 ENSCATP00000030673 ENSCATP00000030673 BAK1 BAK1 TP53 TP53 AKT2 AKT2 ENSCATP00000032242 ENSCATP00000032242 CAMK1G CAMK1G GADD45B GADD45B E2F1 E2F1 CALM1 CALM1 EGFR EGFR E2F3 E2F3 SHC4 SHC4 CALML4 CALML4 CCND1 CCND1 MTOR MTOR GADD45A GADD45A NRAS NRAS GADD45G GADD45G EGF EGF ENSCATP00000037667 ENSCATP00000037667 CAMK2G CAMK2G PIK3CD PIK3CD ENSCATP00000038535 ENSCATP00000038535 SOS2 SOS2 ENSCATP00000040020 ENSCATP00000040020 PDGFB PDGFB TGFA TGFA IGF1 IGF1 SHC3 SHC3 GRB2 GRB2 ENSCATP00000043586 ENSCATP00000043586 PDGFRB PDGFRB CALML6 CALML6 MDM2 MDM2 ENSCATP00000000560 ENSCATP00000000560 PDGFA PDGFA CDKN2A CDKN2A POLK POLK CEP152 CEP152 TPTE2 TPTE2 SOS1 SOS1 ENSCATP00000004066 ENSCATP00000004066 BAX BAX ERAS ERAS CDKN1A CDKN1A CDK4 CDK4 RB1 RB1 PDGFRA PDGFRA AKT1 AKT1 CALML3 CALML3 ENSCATP00000006855 ENSCATP00000006855 PVALEF PVALEF ENSCATP00000007407 ENSCATP00000007407 PRKCB PRKCB IGF1R IGF1R CAMK1 CAMK1 ENSCATP00000010452 ENSCATP00000010452 MAPK3 MAPK3 E2F2 E2F2 KRAS KRAS ARAF ARAF ENSCATP00000012945 ENSCATP00000012945 PTEN PTEN MAP2K2 MAP2K2 PRKCA PRKCA HRAS HRAS CAMK1D CAMK1D MAPK1 MAPK1 AKT3 AKT3 CALM2 CALM2 PLCG2 PLCG2 CAMK2B CAMK2B CAMK4 CAMK4 PRKCG PRKCG BRAF BRAF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ARSIArylsulfatase family member I. (569 aa)
PIK3R2Uncharacterized protein. (624 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
LOC105585293Uncharacterized protein. (290 aa)
RAF1Uncharacterized protein. (668 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
CALM3Calmodulin 3. (149 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
SHC1SHC adaptor protein 1. (584 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa)
ENSCATP00000030673Uncharacterized protein. (652 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSCATP00000032242Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
E2F1E2F transcription factor 1. (437 aa)
CALM1Calmodulin 1. (149 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
E2F3E2F transcription factor 3. (467 aa)
SHC4SHC adaptor protein 4. (630 aa)
CALML4Calmodulin like 4. (193 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
ENSCATP00000037667Protein kinase domain-containing protein. (365 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSCATP00000038535E2F_CC-MB domain-containing protein. (193 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
ENSCATP00000040020Uncharacterized protein; Belongs to the calmodulin family. (91 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
TGFATransforming growth factor alpha. (166 aa)
IGF1Insulin like growth factor 1. (208 aa)
SHC3SHC adaptor protein 3. (598 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSCATP00000043586Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CALML6Calmodulin like 6. (181 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
ENSCATP00000000560C2 tensin-type domain-containing protein. (165 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
POLKDNA polymerase kappa. (845 aa)
CEP152Centrosomal protein 152. (1706 aa)
TPTE2Uncharacterized protein. (550 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
ENSCATP00000004066Uncharacterized protein. (189 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
ERASES cell expressed Ras. (233 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RB1RB transcriptional corepressor 1. (926 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1024 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ENSCATP00000006855Uncharacterized protein. (519 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
ENSCATP00000007407PID domain-containing protein. (502 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
IGF1RTyrosine-protein kinase receptor. (1366 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
ENSCATP00000010452Uncharacterized protein. (596 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
E2F2E2F transcription factor 2. (437 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
ENSCATP00000012945Protein kinase domain-containing protein. (101 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (385 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1236 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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