STRINGSTRING
E2F1 E2F1 GADD45B GADD45B AKT2 AKT2 TP53 TP53 FGF23 FGF23 FGF10 FGF10 BAK1 BAK1 FGF19 FGF19 ENSCATP00000030673 ENSCATP00000030673 PPP1R14B PPP1R14B MAP2K1 MAP2K1 PIK3R1 PIK3R1 DDB2 DDB2 PIK3R3 PIK3R3 CSDE1 CSDE1 PIK3CA PIK3CA FGF6 FGF6 MITF MITF PDGFC PDGFC CDK6 CDK6 RAF1 RAF1 PIK3CB PIK3CB PIK3R2 PIK3R2 FGF4 FGF4 BRAF BRAF GALK2 GALK2 AKT3 AKT3 LOC105572981 LOC105572981 BAD BAD PDGFD PDGFD FGF1 FGF1 FGF8 FGF8 MAPK1 MAPK1 HRAS HRAS MAP2K2 MAP2K2 PTEN PTEN ENSCATP00000012945 ENSCATP00000012945 ARAF ARAF FGF16 FGF16 KRAS KRAS E2F2 E2F2 MAPK3 MAPK3 ENSCATP00000010452 ENSCATP00000010452 FGF9 FGF9 IGF1R IGF1R FGF3 FGF3 AKT1 AKT1 PDGFRA PDGFRA RB1 RB1 CDK4 CDK4 CDKN1A CDKN1A ERAS ERAS BAX BAX ENSCATP00000004066 ENSCATP00000004066 TPTE2 TPTE2 POLK POLK CDKN2A CDKN2A FGF20 FGF20 FGF2 FGF2 PDGFA PDGFA ENSCATP00000000560 ENSCATP00000000560 ENSCATP00000000152 ENSCATP00000000152 FGF5 FGF5 FGF17 FGF17 MDM2 MDM2 PDGFRB PDGFRB IGF1 IGF1 FGFR1 FGFR1 MET MET FGF7 FGF7 PDGFB PDGFB FGF22 FGF22 ENSCATP00000038535 ENSCATP00000038535 PIK3CD PIK3CD ENSCATP00000037667 ENSCATP00000037667 CDH1 CDH1 EGF EGF GADD45G GADD45G NRAS NRAS GADD45A GADD45A FGF18 FGF18 CCND1 CCND1 FGF21 FGF21 HGF HGF E2F3 E2F3 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
E2F1E2F transcription factor 1. (437 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ENSCATP00000030673Uncharacterized protein. (652 aa)
PPP1R14BUncharacterized protein. (207 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
MITFMelanocyte inducing transcription factor. (519 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RAF1Uncharacterized protein. (668 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PIK3R2Uncharacterized protein. (624 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
GALK2Galactokinase 2. (458 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC105572981Uncharacterized protein. (132 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ENSCATP00000012945Protein kinase domain-containing protein. (101 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
E2F2E2F transcription factor 2. (437 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
ENSCATP00000010452Uncharacterized protein. (596 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
IGF1RTyrosine-protein kinase receptor. (1366 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1024 aa)
RB1RB transcriptional corepressor 1. (926 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ERASES cell expressed Ras. (233 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
ENSCATP00000004066Uncharacterized protein. (189 aa)
TPTE2Uncharacterized protein. (550 aa)
POLKDNA polymerase kappa. (845 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
ENSCATP00000000560C2 tensin-type domain-containing protein. (165 aa)
ENSCATP00000000152Uncharacterized protein. (64 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
IGF1Insulin like growth factor 1. (208 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ENSCATP00000038535E2F_CC-MB domain-containing protein. (193 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSCATP00000037667Protein kinase domain-containing protein. (365 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
E2F3E2F transcription factor 3. (467 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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