STRINGSTRING
ENSCATP00000043586 ENSCATP00000043586 HMOX1 HMOX1 SDC1 SDC1 CTSL CTSL MGST2 MGST2 FOS FOS CALML6 CALML6 NFKB1 NFKB1 RHOC RHOC IL1R2 IL1R2 MAP3K7 MAP3K7 CHUK CHUK CCL2 CCL2 MAPK10 MAPK10 KLF2 KLF2 ACVR1 ACVR1 ENSCATP00000041705 ENSCATP00000041705 LOC105573641 LOC105573641 GSTM2 GSTM2 NCF2 NCF2 PDGFB PDGFB ENSCATP00000040020 ENSCATP00000040020 BMP4 BMP4 ENSCATP00000039367 ENSCATP00000039367 MAPK14 MAPK14 HSP90AA1 HSP90AA1 PIK3CD PIK3CD MAP2K4 MAP2K4 NOXA1 NOXA1 MEF2C MEF2C GSTM3 GSTM3 RELA RELA PRKAA2 PRKAA2 IL1A IL1A ENSCATP00000036022 ENSCATP00000036022 MAP2K5 MAP2K5 TXN2 TXN2 NOS3 NOS3 ENSCATP00000035097 ENSCATP00000035097 RAC2 RAC2 CALML4 CALML4 LOC105579900 LOC105579900 PRKAA1 PRKAA1 MGST1 MGST1 SUMO2 SUMO2 ENSCATP00000032866 ENSCATP00000032866 CALM1 CALM1 SDC4 SDC4 ENSCATP00000032242 ENSCATP00000032242 AKT2 AKT2 TP53 TP53 ENSCATP00000031483 ENSCATP00000031483 ENSCATP00000031206 ENSCATP00000031206 PIAS4 PIAS4 GSTM1 GSTM1 ENSCATP00000030652 ENSCATP00000030652 SDC2 SDC2 ENSCATP00000029205 ENSCATP00000029205 VCAM1 VCAM1 ITGAV ITGAV ACVR2B ACVR2B CDH5 CDH5 ENSCATP00000028019 ENSCATP00000028019 PIK3R1 PIK3R1 GSTT4 GSTT4 PIK3R3 PIK3R3 PIK3CA PIK3CA NFE2L2 NFE2L2 ENSCATP00000026831 ENSCATP00000026831 CALM3 CALM3 ICAM1 ICAM1 GSTT2B GSTT2B PRKCZ PRKCZ ENSCATP00000025219 ENSCATP00000025219 ENSCATP00000024775 ENSCATP00000024775 ACTL8 ACTL8 PIK3CB PIK3CB SUMO1 SUMO1 PIK3R2 PIK3R2 HSP90AB1 HSP90AB1 ENSCATP00000023477 ENSCATP00000023477 IFNG IFNG ENSCATP00000022567 ENSCATP00000022567 CYBA CYBA ITGA2B ITGA2B CTNNB1 CTNNB1 TNFRSF1A TNFRSF1A SQSTM1 SQSTM1 MAPK12 MAPK12 TXN TXN MAPK7 MAPK7 GSTO2 GSTO2 PTTG1IP PTTG1IP CALM2 CALM2 MAPK9 MAPK9 CAV3 CAV3 ACVR2A ACVR2A ENSCATP00000019657 ENSCATP00000019657 AKT3 AKT3 TXNDC8 TXNDC8 ENSCATP00000019334 ENSCATP00000019334 BMPR1A BMPR1A IKBKB IKBKB BMPR2 BMPR2 GSTA2 GSTA2 IL1B IL1B GSTP1 GSTP1 ENSCATP00000017016 ENSCATP00000017016 ITGB3 ITGB3 CAV2 CAV2 ENSCATP00000015541 ENSCATP00000015541 GPC1 GPC1 NOX1 NOX1 ACTB ACTB CAV1 CAV1 EDN1 EDN1 IKBKG IKBKG KEAP1 KEAP1 RAC1 RAC1 VEGFA VEGFA MMP9 MMP9 ARHGEF2 ARHGEF2 RAC3 RAC3 ENSCATP00000010735 ENSCATP00000010735 BMPR1B BMPR1B MAPK11 MAPK11 TXNDC2 TXNDC2 DUSP1 DUSP1 PECAM1 PECAM1 GSTA4 GSTA4 KDR KDR NQO1 NQO1 MGST3 MGST3 ENSCATP00000007830 ENSCATP00000007830 ACTL7B ACTL7B SELE SELE ENSCATP00000007363 ENSCATP00000007363 ACTL7A ACTL7A PVALEF PVALEF CALML3 CALML3 MAPK13 MAPK13 AKT1 AKT1 GSTO1 GSTO1 PLAT PLAT MAP3K5 MAP3K5 ACTRT1 ACTRT1 RHOA RHOA HSP90B1 HSP90B1 TRPV4 TRPV4 ENSCATP00000005174 ENSCATP00000005174 PTK2 PTK2 NPPC NPPC ENSCATP00000004545 ENSCATP00000004545 SRC SRC ENSCATP00000004013 ENSCATP00000004013 MMP2 MMP2 MEF2A MEF2A LOC105579060 LOC105579060 ASS1 ASS1 ENSCATP00000002884 ENSCATP00000002884 MAP2K7 MAP2K7 ENSCATP00000002799 ENSCATP00000002799 LOC105599377 LOC105599377 MAPK8 MAPK8 ACTG1 ACTG1 TNF TNF PDGFA PDGFA NCF1 NCF1 ENSCATP00000000012 ENSCATP00000000012 BCL2 BCL2 IL1R1 IL1R1 MAP2K6 MAP2K6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCATP00000043586Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
HMOX1Heme oxygenase 1. (311 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CALML6Calmodulin like 6. (181 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
RHOCRas homolog family member C. (193 aa)
IL1R2Interleukin 1 receptor type 2. (398 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (586 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CCL2C-C motif chemokine. (99 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
KLF2Kruppel like factor 2. (355 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ENSCATP00000041705Uncharacterized protein. (296 aa)
LOC105573641Uncharacterized protein; Belongs to the actin family. (323 aa)
GSTM2Glutathione S-transferase. (222 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENSCATP00000040020Uncharacterized protein; Belongs to the calmodulin family. (91 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ENSCATP00000039367Uncharacterized protein. (360 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (831 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa)
NOXA1NADPH oxidase activator 1. (483 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
GSTM3Glutathione S-transferase. (225 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (271 aa)
ENSCATP00000036022Thioredoxin; Belongs to the thioredoxin family. (106 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (472 aa)
TXN2Thioredoxin 2. (166 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ENSCATP00000035097Uncharacterized protein. (213 aa)
RAC2Rac family small GTPase 2. (192 aa)
CALML4Calmodulin like 4. (193 aa)
LOC105579900Uncharacterized protein. (319 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
ENSCATP00000032866Uncharacterized protein. (66 aa)
CALM1Calmodulin 1. (149 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
ENSCATP00000032242Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
ENSCATP00000031483Uncharacterized protein. (171 aa)
ENSCATP00000031206Ubiquitin-like domain-containing protein. (128 aa)
PIAS4Protein inhibitor of activated STAT 4. (515 aa)
GSTM1Glutathione S-transferase mu 1; Belongs to the GST superfamily. (236 aa)
ENSCATP00000030652Ubiquitin-like domain-containing protein. (136 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
ENSCATP00000029205Rad60-SLD domain-containing protein. (74 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
ENSCATP00000028019HATPase_c domain-containing protein. (647 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GSTT4Glutathione S-transferase theta 4; Belongs to the GST superfamily. (241 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
ENSCATP00000026831Uncharacterized protein. (339 aa)
CALM3Calmodulin 3. (149 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
GSTT2BUncharacterized protein; Belongs to the GST superfamily. (250 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
ENSCATP00000025219Thioredoxin domain-containing protein. (94 aa)
ENSCATP00000024775Uncharacterized protein. (90 aa)
ACTL8Actin like 8; Belongs to the actin family. (386 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
SUMO1Ubiquitin-like domain-containing protein. (146 aa)
PIK3R2Uncharacterized protein. (624 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
ENSCATP00000023477Uncharacterized protein. (452 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
ENSCATP00000022567Rad60-SLD domain-containing protein. (78 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1090 aa)
CTNNB1Catenin beta 1. (781 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
SQSTM1Sequestosome 1. (440 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
PTTG1IPPTTG1 interacting protein. (180 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (514 aa)
ENSCATP00000019657Uncharacterized protein; Belongs to the actin family. (368 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TXNDC8Thioredoxin domain containing 8. (127 aa)
ENSCATP00000019334Uncharacterized protein. (425 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (997 aa)
GSTA2Glutathione S-transferase alpha 2; Belongs to the GST superfamily. (222 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
ENSCATP00000017016Uncharacterized protein; Belongs to the GST superfamily. (202 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
ENSCATP00000015541Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (462 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
NOX1NADPH oxidase 1. (564 aa)
ACTBUncharacterized protein. (375 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
EDN1Endothelin 1. (211 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
RAC1Uncharacterized protein. (212 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (409 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
RAC3Rac family small GTPase 3. (205 aa)
ENSCATP00000010735Ubiquitin-like domain-containing protein. (132 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
TXNDC2Thioredoxin domain-containing protein. (367 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (721 aa)
GSTA4Glutathione S-transferase alpha 4. (222 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
MGST3Microsomal glutathione S-transferase 3. (166 aa)
ENSCATP00000007830Uncharacterized protein. (436 aa)
ACTL7BActin like 7B; Belongs to the actin family. (415 aa)
SELESelectin E. (610 aa)
ENSCATP00000007363Uncharacterized protein. (150 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (241 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (375 aa)
RHOARas homolog family member A. (193 aa)
HSP90B1Heat shock protein 90 beta family member 1. (804 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
ENSCATP00000005174Uncharacterized protein. (224 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1068 aa)
NPPCNatriuretic peptide C. (126 aa)
ENSCATP00000004545Small ubiquitin-related modifier. (101 aa)
SRCTyrosine-protein kinase. (644 aa)
ENSCATP00000004013Uncharacterized protein. (711 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
MEF2AMyocyte enhancer factor 2A. (504 aa)
LOC105579060HATPase_c domain-containing protein. (641 aa)
ASS1Uncharacterized protein. (412 aa)
ENSCATP00000002884HATPase_c domain-containing protein. (680 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (517 aa)
ENSCATP00000002799Thioredoxin; Belongs to the thioredoxin family. (101 aa)
LOC105599377Uncharacterized protein. (266 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
ACTG1Actin gamma 1. (377 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
NCF1Neutrophil cytosolic factor 1. (423 aa)
ENSCATP00000000012Protein kinase domain-containing protein. (231 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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