STRINGSTRING
IL5 IL5 ENSMFAP00000045924 ENSMFAP00000045924 PAX8 PAX8 IL6 IL6 TSHR TSHR GFER GFER ERBB2 ERBB2 KRT5 KRT5 AMBN AMBN LGR5 LGR5 KRT19 KRT19 IL4 IL4 AMTN AMTN NPHS1 NPHS1 CD2AP CD2AP PLA2R1 PLA2R1 SERPINB5 SERPINB5 TFF3 TFF3 ODAM ODAM GULP1 GULP1 IL1B IL1B KRT14 KRT14 TG TG KRT7 KRT7 CDH1 CDH1 IL13 IL13 ENAM ENAM WT1 WT1 IFT122 IFT122 DLAT DLAT NPHS2 NPHS2 PODXL PODXL CTNNB1 CTNNB1 ENSMFAP00000006765 ENSMFAP00000006765 EIF4E2 EIF4E2 KLK4 KLK4 MUC5B MUC5B MMP20 MMP20 ACTN4 ACTN4 KRT8 KRT8 TNF TNF TPO TPO SYNPO SYNPO SLC5A5 SLC5A5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
ENSMFAP00000045924IF rod domain-containing protein; Belongs to the intermediate filament family. (547 aa)
PAX8Paired box 8. (456 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (212 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
GFERSulfhydryl oxidase. (205 aa)
ERBB2Receptor protein-tyrosine kinase. (1406 aa)
KRT5Keratin 5; Belongs to the intermediate filament family. (593 aa)
AMBNAmeloblastin. (447 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (400 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. (153 aa)
AMTNAmelotin. (208 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1244 aa)
CD2APCD2 associated protein. (639 aa)
PLA2R1Phospholipase A2 receptor 1. (1466 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (375 aa)
TFF3Trefoil factor 3. (94 aa)
ODAMOdontogenic, ameloblast associated. (279 aa)
GULP1GULP PTB domain containing engulfment adaptor 1. (304 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
KRT14Keratin 14; Belongs to the intermediate filament family. (475 aa)
TGThyroglobulin. (2689 aa)
KRT7Keratin 7; Belongs to the intermediate filament family. (469 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
IL13Interleukin 13. (146 aa)
ENAMEnamelin. (1138 aa)
WT1WT1 transcription factor. (513 aa)
IFT122Intraflagellar transport 122. (1241 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
NPHS2NPHS2 stomatin family member, podocin. (383 aa)
PODXLPodocalyxin like. (585 aa)
CTNNB1Catenin beta 1. (781 aa)
ENSMFAP00000006765Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (503 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
KLK4Kallikrein related peptidase 4; Belongs to the peptidase S1 family. (254 aa)
MUC5BMucin 5B, oligomeric mucus/gel-forming. (4900 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
ACTN4Actinin alpha 4. (931 aa)
KRT8IF rod domain-containing protein; Belongs to the intermediate filament family. (483 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
TPOThyroid peroxidase. (855 aa)
SYNPOSynaptopodin. (929 aa)
SLC5A5Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (523 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.