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| | STAT1 | Signal transducer and activator of transcription. (758 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | CARD11 | Caspase recruitment domain family member 11. (1127 aa) |
| | PECAM1 | Platelet and endothelial cell adhesion molecule 1. (738 aa) |
| | SF3B1 | Uncharacterized protein. (74 aa) |
| | LOC102115909 | RelB_leu_zip domain-containing protein. (80 aa) |
| | NCL | Nucleolin; Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG- 3' repeats more tightly than the telomeric single-stranded DNA 5'- TTAGGG-3' repeats (By similarity). (736 aa) |
| | CD226 | CD226 molecule. (336 aa) |
| | SELL | L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (385 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1127 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | ENSMFAP00000030790 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (377 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | LY9 | Lymphocyte antigen 9. (627 aa) |
| | ENSMFAP00000029982 | Uncharacterized protein. (102 aa) |
| | CD48 | CD48 molecule. (294 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | SPEN | Spen family transcriptional repressor. (3672 aa) |
| | CFL1 | Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity); Belongs to the actin-binding proteins ADF family. (196 aa) |
| | TNFRSF8 | TNF receptor superfamily member 8. (505 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | GLIS2 | GLIS family zinc finger 2. (524 aa) |
| | ENSMFAP00000028411 | Uncharacterized protein. (785 aa) |
| | SRSF2 | Testis cDNA, clone: QtsA-15801, similar to human splicing factor, arginine/serine-rich 2 (SFRS2). (221 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | NUP98 | Nucleoporin 98. (1610 aa) |
| | SHC1 | SHC adaptor protein 1. (584 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (925 aa) |
| | ENSMFAP00000027007 | Ldh_1_N domain-containing protein. (197 aa) |
| | ENSMFAP00000027000 | Pyruvate kinase; Belongs to the pyruvate kinase family. (142 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1310 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | PTK7 | Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa) |
| | USP16 | Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiqu [...] (826 aa) |
| | PKM | Pyruvate kinase; Belongs to the pyruvate kinase family. (556 aa) |
| | BCR | BCR activator of RhoGEF and GTPase. (1227 aa) |
| | BMP2K | BMP2 inducible kinase. (1144 aa) |
| | BRCA1 | Uncharacterized protein. (1884 aa) |
| | ENSMFAP00000025493 | Uncharacterized protein. (274 aa) |
| | CD1D | CD1d molecule. (337 aa) |
| | MAML1 | Mastermind like transcriptional coactivator 1. (788 aa) |
| | ENSMFAP00000025396 | Uncharacterized protein. (274 aa) |
| | ENSMFAP00000025317 | Hist_deacetyl domain-containing protein. (258 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | CD44 | CD44 molecule (Indian blood group). (742 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (450 aa) |
| | TET2 | Tet methylcytosine dioxygenase 2. (2019 aa) |
| | TXNRD1 | Thioredoxin reductase 1. (567 aa) |
| | ENSMFAP00000023932 | Uncharacterized protein. (256 aa) |
| | IL2RG | Fibronectin type-III domain-containing protein. (369 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa) |
| | SIRT2 | NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...] (389 aa) |
| | EGR2 | Early growth response 2. (489 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | LMNB1 | Lamin B1; Belongs to the intermediate filament family. (586 aa) |
| | PLXNB1 | Plexin B1. (2140 aa) |
| | CD82 | Tetraspanin. (266 aa) |
| | CD7 | CD7 molecule. (240 aa) |
| | ENSMFAP00000021521 | Uncharacterized protein. (154 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | ENSMFAP00000021023 | Ku domain-containing protein. (583 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa) |
| | PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa) |
| | FMNL1 | Formin like 1. (1107 aa) |
| | TSC2 | TSC complex subunit 2. (1807 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | NT5E | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) |
| | SQSTM1 | Sequestosome 1. (440 aa) |
| | PDE7B | Phosphodiesterase. (505 aa) |
| | RUNX1 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa) |
| | MED12 | Mediator complex subunit 12. (2178 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | TCF3 | Transcription factor 3. (654 aa) |
| | SLAMF6 | SLAM family member 6. (338 aa) |
| | ENSMFAP00000018989 | Ku domain-containing protein. (498 aa) |
| | BCL11B | BAF chromatin remodeling complex subunit BCL11B. (870 aa) |
| | MYBL2 | MYB proto-oncogene like 2. (700 aa) |
| | STAT5B | Signal transducer and activator of transcription. (763 aa) |
| | DKC1 | Dyskerin pseudouridine synthase 1. (597 aa) |
| | RELB | RELB proto-oncogene, NF-kB subunit. (526 aa) |
| | ARHGEF1 | Rho guanine nucleotide exchange factor 1. (1052 aa) |
| | ENSMFAP00000018412 | HATPase_c domain-containing protein. (644 aa) |
| | SLC3A2-2 | Aamy domain-containing protein. (483 aa) |
| | USP9X | Ubiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2584 aa) |
| | SRC | Tyrosine-protein kinase. (542 aa) |
| | SLC2A1 | Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa) |
| | CANX | Calnexin. (592 aa) |
| | SLC3A2 | Uncharacterized protein. (148 aa) |
| | CD1C | CD1c molecule. (332 aa) |
| | RPS6KB2 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa) |
| | LCK | Tyrosine-protein kinase. (342 aa) |
| | ILRUN | Inflammation and lipid regulator with UBA-like and NBR1-like domains. (298 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | SBF1 | SET binding factor 1. (1893 aa) |
| | ENSMFAP00000016028 | Uncharacterized protein. (232 aa) |
| | ENSMFAP00000015614 | Uncharacterized protein. (506 aa) |
| | STAG2 | Stromal antigen 2. (1268 aa) |
| | CD83 | CD83 molecule. (205 aa) |
| | CR2 | Complement C3d receptor 2. (1093 aa) |
| | ENSMFAP00000014199 | HATPase_c domain-containing protein. (307 aa) |
| | ASXL1 | ASXL transcriptional regulator 1. (1541 aa) |
| | HSPA4 | Heat shock protein family A (Hsp70) member 4. (840 aa) |
| | SRSF8 | Serine and arginine rich splicing factor 8. (287 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1632 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | ICAM1 | Intercellular adhesion molecule 1. (532 aa) |
| | CTTN | Cortactin. (550 aa) |
| | ZBTB5 | Zinc finger and BTB domain containing 5. (677 aa) |
| | ENSMFAP00000012209 | ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (153 aa) |
| | LOC102142638 | Protein kinase domain-containing protein. (297 aa) |
| | BCL11A | BAF chromatin remodeling complex subunit BCL11A. (838 aa) |
| | HDAC9 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | CCNL2 | Cyclin L2; Belongs to the cyclin family. (520 aa) |
| | CCNH | Cyclin-H; Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout t [...] (325 aa) |
| | ENSMFAP00000010148 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa) |
| | PDE4A | Phosphodiesterase. (832 aa) |
| | MYH9 | Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa) |
| | IKZF1 | IKAROS family zinc finger 1. (519 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (488 aa) |
| | NPM1 | Uncharacterized protein. (305 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (762 aa) |
| | ENSMFAP00000008565 | PID domain-containing protein. (467 aa) |
| | CTCF | CCCTC-binding factor. (727 aa) |
| | NOTCH2 | Notch receptor 2. (2610 aa) |
| | ITGA4 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | CD5 | CD5 molecule. (486 aa) |
| | ITGB2 | Integrin beta. (874 aa) |
| | MLLT3 | MLLT3 super elongation complex subunit. (570 aa) |
| | ENSMFAP00000006551 | Uncharacterized protein. (229 aa) |
| | ENSMFAP00000006511 | Bromo domain-containing protein. (653 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa) |
| | WAS | WASP actin nucleation promoting factor. (503 aa) |
| | ENSMFAP00000006058 | Uncharacterized protein. (305 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | TIAM1 | T cell lymphoma invasion and metastasis 1. (1591 aa) |
| | ENSMFAP00000005508 | Pyruvate kinase; Belongs to the pyruvate kinase family. (332 aa) |
| | SEMA4D | Semaphorin 4D; Belongs to the semaphorin family. (862 aa) |
| | PML | Promyelocytic leukemia. (882 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | CD96 | CD96 molecule. (587 aa) |
| | PDCD4 | Programmed cell death 4. (471 aa) |
| | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase. (335 aa) |
| | ENSMFAP00000003951 | Ku domain-containing protein. (542 aa) |
| | SETD2 | SET domain containing 2, histone lysine methyltransferase. (2544 aa) |
| | CDK7 | Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa) |
| | CD38 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system (By similarity). (301 aa) |
| | BAG6 | BCL2 associated athanogene 6. (1132 aa) |
| | ALB | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa) |
| | FOXN3 | Forkhead box N3. (493 aa) |
| | SPN | Sialophorin. (405 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | ATG7 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa) |
| | HNRNPK | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (464 aa) |
| | ENSMFAP00000001669 | Uncharacterized protein. (268 aa) |
| | GRB2 | Growth factor receptor-binding protein 2. (217 aa) |
| | HLA-E | Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (382 aa) |
| | LAIR1 | Leukocyte associated immunoglobulin like receptor 1. (287 aa) |
| | JUND | JunD proto-oncogene, AP-1 transcription factor subunit. (325 aa) |
| | NR3C1 | Nuclear receptor subfamily 3 group C member 1. (778 aa) |
| | ENSMFAP00000000767 | Uncharacterized protein. (208 aa) |
| | CD247 | Uncharacterized protein. (168 aa) |
| | FOXO3 | Forkhead box O3. (672 aa) |
| | ENSMFAP00000000260 | Uncharacterized protein. (454 aa) |
| | CCNT2 | Cyclin T2; Belongs to the cyclin family. (760 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (292 aa) |
| | BRD2 | Uncharacterized protein. (802 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | ETV6 | ETS variant 6. (452 aa) |
| | ITK | Tyrosine-protein kinase. (620 aa) |
| | TFRC | Transferrin receptor. (760 aa) |
| | PTPN23 | Protein tyrosine phosphatase non-receptor type 23. (1633 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (212 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa) |
| | DOCK2 | Dedicator of cytokinesis 2; Belongs to the DOCK family. (1725 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in [...] (790 aa) |
| | EIF4EBP1 | Eukaryotic translation initiation factor 4E binding protein 1. (118 aa) |
| | ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase. (901 aa) |
| | EP300 | E1A binding protein p300. (2414 aa) |
| | LCP2 | Lymphocyte cytosolic protein 2. (533 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (736 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | CD47 | CD47 molecule. (323 aa) |
| | ABCC1 | Multidrug resistance-associated protein 1; Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). Participates in [...] (1496 aa) |
| | CDK1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa) |
| | ENSMFAP00000043974 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (820 aa) |
| | ENSMFAP00000043772 | Uncharacterized protein. (457 aa) |
| | ENSMFAP00000043489 | Pyruvate kinase; Belongs to the pyruvate kinase family. (525 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | EZH2 | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is m [...] (751 aa) |
| | DGCR8 | DGCR8 microprocessor complex subunit. (773 aa) |
| | CADM1 | Cell adhesion molecule 1. (473 aa) |
| | CBL | Cbl proto-oncogene. (907 aa) |
| | THRAP3 | Thyroid hormone receptor associated protein 3. (955 aa) |
| | ENSMFAP00000042686 | RRM domain-containing protein. (260 aa) |
| | SUZ12 | SUZ12 polycomb repressive complex 2 subunit. (739 aa) |
| | ENSMFAP00000042604 | Pyruvate kinase; Belongs to the pyruvate kinase family. (455 aa) |
| | ENSMFAP00000042423 | Protein kinase domain-containing protein. (140 aa) |
| | HCLS1 | SH3 domain-containing protein. (475 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | ENSMFAP00000042011 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa) |
| | KMT2A | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3932 aa) |
| | RAD9A | Cell cycle checkpoint control protein RAD9A; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN [...] (390 aa) |
| | LDHA | L-lactate dehydrogenase A chain. (337 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | GSK3A | Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa) |
| | ENSMFAP00000039975 | ADF-H domain-containing protein. (135 aa) |
| | SIRT1 | Sirtuin 1. (743 aa) |
| | ENSMFAP00000039726 | Fork-head domain-containing protein. (457 aa) |
| | ENSMFAP00000039031 | Uncharacterized protein; Belongs to the LDH/MDH superfamily. (337 aa) |
| | KMT2D | Lysine methyltransferase 2D. (5538 aa) |
| | DOCK10 | Dedicator of cytokinesis 10; Belongs to the DOCK family. (2145 aa) |
| | SLC29A1 | Solute carrier family 29 member 1 (Augustine blood group). (456 aa) |
| | ZAP70 | Tyrosine-protein kinase. (619 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (523 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | UHRF1 | Ubiquitin like with PHD and ring finger domains 1. (859 aa) |
| | ENSMFAP00000036974 | N_BRCA1_IG domain-containing protein. (176 aa) |
| | AKT1S1 | AKT1 substrate 1. (276 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit alpha. (315 aa) |
| | AFF1 | AF4/FMR2 family member 1. (1221 aa) |
| | CDR2 | Cerebellar degeneration related protein 2. (454 aa) |
| | ITGB1 | Integrin beta; Belongs to the integrin beta chain family. (801 aa) |
| | WEE1 | Wee1-like protein kinase. (646 aa) |
| | PIK3R2 | Uncharacterized protein. (694 aa) |
| | IBTK | IBTK. (1352 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | JAK3 | Tyrosine-protein kinase. (1124 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (2091 aa) |
| | ENSMFAP00000035993 | Uncharacterized protein. (1619 aa) |
| | EIF4G1 | Eukaryotic translation initiation factor 4 gamma 1. (1605 aa) |
| | PHRF1 | PHD and ring finger domains 1. (1644 aa) |
| | ADAM10 | ADAM metallopeptidase domain 10. (748 aa) |
| | CD28 | IGv domain-containing protein. (234 aa) |
| | ENSMFAP00000034738 | KH domain-containing protein. (380 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | ENSMFAP00000034109 | ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (158 aa) |
| | XRCC6 | Testis cDNA, clone: QtsA-19002, similar to human thyroid autoantigen 70kDa (Ku antigen) (G22P1). (609 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | LOC102144252 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa) |
| | ADAR | Adenosine deaminase RNA specific. (1228 aa) |
| | ITGAL | VWFA domain-containing protein. (582 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1977 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (414 aa) |
| | HSP90AA1 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (831 aa) |
| | ENSMFAP00000032552 | ROKNT domain-containing protein. (71 aa) |
