(62 nodes) Mixed, incl. Dopamine Neurotransmitter Release Cycle, and Synaptic vesicle fusion to presynaptic active zone membrane network (Macaca fascicularis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APBA2	Amyloid beta precursor protein binding family A member 2. (749 aa)
	RAB3B	RAB3B, member RAS oncogene family. (219 aa)
	STX3	Syntaxin 3; Belongs to the syntaxin family. (302 aa)
	CPLX1	Complexin-1; Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity). (134 aa)
	SYT2	Synaptotagmin 2. (419 aa)
	SNAP25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
	VAMP3	Vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. (100 aa)
	SLC17A7	Solute carrier family 17 member 7. (561 aa)
	SLC17A8	Solute carrier family 17 member 8. (589 aa)
	RAB3C	RAB3C, member RAS oncogene family. (227 aa)
	VAMP1	Vesicle associated membrane protein 1. (118 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (288 aa)
	TXLNA	Taxilin alpha. (546 aa)
	SNAP47	Synaptosome associated protein 47. (463 aa)
	LOC102136620	Uncharacterized protein. (64 aa)
	STX19	Syntaxin 19; Belongs to the syntaxin family. (294 aa)
	SLC18A3	Solute carrier family 18 member A3. (532 aa)
	PPFIA3	PTPRF interacting protein alpha 3. (1194 aa)
	STX11	Syntaxin 11; Belongs to the syntaxin family. (287 aa)
	VAMP5	Vesicle associated membrane protein 5. (116 aa)
	MPP6	Uncharacterized protein; Belongs to the MAGUK family. (582 aa)
	UNC13D	Unc-13 homolog D. (1126 aa)
	SLC18A1	Solute carrier family 18 member A1. (525 aa)
	RAB3A	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...] (220 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1367 aa)
	SLC18A2	Solute carrier family 18 member A2. (485 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (840 aa)
	VAMP2	V-SNARE coiled-coil homology domain-containing protein. (118 aa)
	CCDC134	Coiled-coil domain containing 134. (229 aa)
	TSPOAP1	TSPO associated protein 1. (1874 aa)
	STX1B	Syntaxin 1B; Belongs to the syntaxin family. (288 aa)
	KAZN	Kazrin, periplakin interacting protein. (863 aa)
	ENSMFAP00000022629	Uncharacterized protein. (123 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
	SYT4	Synaptotagmin 4. (425 aa)
	SYT7	Synaptotagmin 7. (686 aa)
	APBA3	Amyloid beta precursor protein binding family A member 3. (575 aa)
	STXBP2	Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (593 aa)
	STX2	Syntaxin 2; Belongs to the syntaxin family. (277 aa)
	STX4	Syntaxin 4; Belongs to the syntaxin family. (171 aa)
	LIN7C	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
	ENSMFAP00000029049	Uncharacterized protein. (1637 aa)
	RIMBP2	RIMS binding protein 2. (1123 aa)
	RIMS3	Regulating synaptic membrane exocytosis 3. (308 aa)
	UNC13A	Unc-13 homolog A. (1592 aa)
	UNC13C	Unc-13 homolog C. (2216 aa)
	UNC13B	Uncharacterized protein. (4336 aa)
	SYT1	Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-in [...] (422 aa)
	SLC32A1	Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Belongs to the amino acid/polyamine transporter 2 family. (525 aa)
	SLC17A6	Solute carrier family 17 member 6. (582 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1692 aa)
	STXBP1	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (625 aa)
	MPP2	Membrane palmitoylated protein 2; Belongs to the MAGUK family. (537 aa)
	SYT9	Synaptotagmin 9. (491 aa)
	LIN7B	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (207 aa)
	MPP1	Membrane palmitoylated protein 1; Belongs to the MAGUK family. (466 aa)
	SNAP23	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
	RIMS4	Regulating synaptic membrane exocytosis 4. (269 aa)
	LIN7A	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
	SYT11	Uncharacterized protein. (431 aa)
	STON2	Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (955 aa)
	STXBP3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBA1	CASK	ENSMFAP00000016512	ENSMFAP00000022644	Amyloid beta precursor protein binding family A member 1.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.995
APBA1	LIN7A	ENSMFAP00000016512	ENSMFAP00000042837	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.812
APBA1	LIN7B	ENSMFAP00000016512	ENSMFAP00000039522	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.725
APBA1	LIN7C	ENSMFAP00000016512	ENSMFAP00000028432	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.798
APBA1	LOC102136620	ENSMFAP00000016512	ENSMFAP00000009621	Amyloid beta precursor protein binding family A member 1.	Uncharacterized protein.	0.618
APBA1	MPP1	ENSMFAP00000016512	ENSMFAP00000040019	Amyloid beta precursor protein binding family A member 1.	Membrane palmitoylated protein 1; Belongs to the MAGUK family.	0.835
APBA1	MPP2	ENSMFAP00000016512	ENSMFAP00000036930	Amyloid beta precursor protein binding family A member 1.	Membrane palmitoylated protein 2; Belongs to the MAGUK family.	0.700
APBA1	MPP6	ENSMFAP00000016512	ENSMFAP00000012533	Amyloid beta precursor protein binding family A member 1.	Uncharacterized protein; Belongs to the MAGUK family.	0.700
APBA1	PPFIA3	ENSMFAP00000016512	ENSMFAP00000010638	Amyloid beta precursor protein binding family A member 1.	PTPRF interacting protein alpha 3.	0.518
APBA1	RAB3B	ENSMFAP00000016512	ENSMFAP00000000033	Amyloid beta precursor protein binding family A member 1.	RAB3B, member RAS oncogene family.	0.508
APBA1	RIMS1	ENSMFAP00000016512	ENSMFAP00000036213	Amyloid beta precursor protein binding family A member 1.	Regulating synaptic membrane exocytosis 1.	0.441
APBA1	RIMS2	ENSMFAP00000016512	ENSMFAP00000015954	Amyloid beta precursor protein binding family A member 1.	Regulating synaptic membrane exocytosis 2.	0.938
APBA1	RIMS3	ENSMFAP00000016512	ENSMFAP00000031381	Amyloid beta precursor protein binding family A member 1.	Regulating synaptic membrane exocytosis 3.	0.625
APBA1	SNAP25	ENSMFAP00000016512	ENSMFAP00000003957	Amyloid beta precursor protein binding family A member 1.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.573
APBA1	STX11	ENSMFAP00000016512	ENSMFAP00000010670	Amyloid beta precursor protein binding family A member 1.	Syntaxin 11; Belongs to the syntaxin family.	0.463
APBA1	STX19	ENSMFAP00000016512	ENSMFAP00000010409	Amyloid beta precursor protein binding family A member 1.	Syntaxin 19; Belongs to the syntaxin family.	0.445
APBA1	STX1A	ENSMFAP00000016512	ENSMFAP00000007349	Amyloid beta precursor protein binding family A member 1.	Syntaxin 1A; Belongs to the syntaxin family.	0.774
APBA1	STX1B	ENSMFAP00000016512	ENSMFAP00000018785	Amyloid beta precursor protein binding family A member 1.	Syntaxin 1B; Belongs to the syntaxin family.	0.762
APBA1	STX2	ENSMFAP00000016512	ENSMFAP00000026531	Amyloid beta precursor protein binding family A member 1.	Syntaxin 2; Belongs to the syntaxin family.	0.618
APBA1	STX3	ENSMFAP00000016512	ENSMFAP00000000204	Amyloid beta precursor protein binding family A member 1.	Syntaxin 3; Belongs to the syntaxin family.	0.618

page 1 of 89

Server load: low (20%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About