STRINGSTRING
BCL2L10 BCL2L10 BCL2A1 BCL2A1 DFFB DFFB TNFRSF10B TNFRSF10B BCL2 BCL2 TNFRSF10A TNFRSF10A ENSMFAP00000013592 ENSMFAP00000013592 BAK1 BAK1 CYCS CYCS ENSMFAP00000014371 ENSMFAP00000014371 ZBP1 ZBP1 PIDD1 PIDD1 CASP10 CASP10 FAS FAS BAX BAX BBC3 BBC3 ENSMFAP00000022286 ENSMFAP00000022286 BAD BAD ENSMFAP00000023078 ENSMFAP00000023078 BMF BMF CASP9 CASP9 BCL2L1 BCL2L1 BID BID CASP7 CASP7 FADD FADD BIK BIK CASP2 CASP2 CFLAR CFLAR MCL1 MCL1 CASP3 CASP3 RIPK1 RIPK1 DIABLO DIABLO ENSMFAP00000034444 ENSMFAP00000034444 DFFA DFFA ENSMFAP00000035756 ENSMFAP00000035756 RIPK3 RIPK3 CASP8 CASP8 GLMP GLMP XIAP XIAP BCL2L11 BCL2L11 FASLG FASLG APAF1 APAF1 BOK BOK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL2L10Uncharacterized protein. (194 aa)
BCL2A1BCL2 related protein A1. (175 aa)
DFFBDNA fragmentation factor subunit beta. (356 aa)
TNFRSF10BTNF receptor superfamily member 10b. (445 aa)
BCL2BCL2 apoptosis regulator. (242 aa)
TNFRSF10ATNF receptor superfamily member 10a. (311 aa)
ENSMFAP00000013592Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSMFAP00000014371Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
ZBP1Z-DNA binding protein 1. (420 aa)
PIDD1P53-induced death domain protein 1. (910 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (519 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (333 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
BBC3BCL2 binding component 3. (261 aa)
ENSMFAP00000022286Uncharacterized protein. (156 aa)
BADBCL2 associated agonist of cell death. (167 aa)
ENSMFAP00000023078Uncharacterized protein; Belongs to the peptidase C14A family. (261 aa)
BMFBcl2 modifying factor. (184 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
BCL2L1BCL2 like 1. (233 aa)
BIDBH3 interacting domain death agonist. (244 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (377 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
BIKBCL2 interacting killer. (160 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
MCL1Uncharacterized protein. (350 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
DIABLOUncharacterized protein. (239 aa)
ENSMFAP00000034444Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (97 aa)
DFFADNA fragmentation factor subunit alpha. (331 aa)
ENSMFAP00000035756Uncharacterized protein. (197 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa)
GLMPGlycosylated lysosomal membrane protein. (414 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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