(40 nodes) Mixed, incl. Nuclear Receptor transcription pathway, and Steroid receptor coactivator network (Macaca fascicularis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (453 aa)
	RXRG	Retinoid X receptor gamma. (463 aa)
	NCOR2	Nuclear receptor corepressor 2. (2510 aa)
	PML	Promyelocytic leukemia. (882 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	ESRRG	Estrogen related receptor gamma. (470 aa)
	TBL1X	F-box-like/WD repeat-containing protein TBL1X; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. (569 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (543 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (673 aa)
	CRABP1	Cellular retinoic acid binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
	RARG	Retinoic acid receptor gamma. (454 aa)
	NCOA2	Nuclear receptor coactivator. (1464 aa)
	ENSMFAP00000012453	Hist_deacetyl domain-containing protein. (223 aa)
	NRIP1	Nuclear receptor interacting protein 1. (1155 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (467 aa)
	RARA	Retinoic acid receptor alpha. (462 aa)
	ENSMFAP00000019629	Uncharacterized protein. (331 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa)
	GPS2	G protein pathway suppressor 2. (327 aa)
	ENSMFAP00000021707	Nuclear receptor domain-containing protein. (255 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1122 aa)
	RXRA	Retinoid X receptor alpha. (443 aa)
	SP1	Sp1 transcription factor. (786 aa)
	KMT2E	Lysine methyltransferase 2E. (1859 aa)
	PRAM1	PML-RARA regulated adaptor molecule 1. (698 aa)
	ESR2	Estrogen receptor 2. (530 aa)
	CARM1	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (593 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	NCOA3	Nuclear receptor coactivator. (1420 aa)
	RXRB	Retinoid X receptor beta. (537 aa)
	CRABP2	Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	NCOR1	Nuclear receptor corepressor 1. (2442 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (613 aa)
	NR1D2	Nuclear receptor subfamily 1 group D member 2. (580 aa)
	RARB	Retinoic acid receptor beta. (448 aa)
	NCOA1	Nuclear receptor coactivator 1. (1534 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (461 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (798 aa)

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARM1	ENSMFAP00000012453	ENSMFAP00000031676	ENSMFAP00000012453	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Hist_deacetyl domain-containing protein.	0.434
CARM1	ENSMFAP00000019629	ENSMFAP00000031676	ENSMFAP00000019629	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Uncharacterized protein.	0.469
CARM1	ESR1	ENSMFAP00000031676	ENSMFAP00000043221	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.958
CARM1	ESR2	ENSMFAP00000031676	ENSMFAP00000031270	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Estrogen receptor 2.	0.947
CARM1	GPS2	ENSMFAP00000031676	ENSMFAP00000021312	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	G protein pathway suppressor 2.	0.469
CARM1	HDAC3	ENSMFAP00000031676	ENSMFAP00000005789	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.434
CARM1	NCOA1	ENSMFAP00000031676	ENSMFAP00000040648	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator 1.	0.816
CARM1	NCOA2	ENSMFAP00000031676	ENSMFAP00000012151	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator.	0.843
CARM1	NCOA3	ENSMFAP00000031676	ENSMFAP00000032093	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator.	0.989
CARM1	NCOR1	ENSMFAP00000031676	ENSMFAP00000036582	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor corepressor 1.	0.567
CARM1	NCOR2	ENSMFAP00000031676	ENSMFAP00000005130	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor corepressor 2.	0.579
CARM1	NR1D2	ENSMFAP00000031676	ENSMFAP00000039207	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor subfamily 1 group D member 2.	0.429
CARM1	NR1H2	ENSMFAP00000031676	ENSMFAP00000045696	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor subfamily 1 group H member 2.	0.464
CARM1	NR1H3	ENSMFAP00000031676	ENSMFAP00000004709	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor subfamily 1 group H member 3.	0.464
CARM1	PPARA	ENSMFAP00000031676	ENSMFAP00000017199	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Peroxisome proliferator activated receptor alpha.	0.427
CARM1	PPARG	ENSMFAP00000031676	ENSMFAP00000035941	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.438
CARM1	RXRA	ENSMFAP00000031676	ENSMFAP00000026319	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Retinoid X receptor alpha.	0.479
CARM1	RXRB	ENSMFAP00000031676	ENSMFAP00000034525	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Retinoid X receptor beta.	0.479
CARM1	RXRG	ENSMFAP00000031676	ENSMFAP00000005053	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Retinoid X receptor gamma.	0.479
CARM1	SP1	ENSMFAP00000031676	ENSMFAP00000027784	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Sp1 transcription factor.	0.904

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