STRINGSTRING
DGKE DGKE PNPLA8 PNPLA8 MOGAT3 MOGAT3 AGPAT5 AGPAT5 PLD4 PLD4 LYPLA2 LYPLA2 PLPP4 PLPP4 LPIN3 LPIN3 LIPG LIPG PLA2G12A PLA2G12A TMEM86B TMEM86B LPCAT3 LPCAT3 PLA2G2E PLA2G2E PLA2G7 PLA2G7 AGPAT3 AGPAT3 CDS1 CDS1 PNLIP PNLIP MBOAT1 MBOAT1 PTGES2 PTGES2 GDPD1 GDPD1 PTDSS1 PTDSS1 PLB1 PLB1 PNPLA3 PNPLA3 TAMM41 TAMM41 FADS2 FADS2 ALOXE3 ALOXE3 MOGAT1 MOGAT1 ALOX12B ALOX12B PISD PISD LPGAT1 LPGAT1 LTA4H LTA4H PAFAH1B2 PAFAH1B2 ALOX5 ALOX5 PLPP3 PLPP3 PAFAH1B1 PAFAH1B1 PTGS2 PTGS2 TAZ TAZ AKAP9 AKAP9 PLPP1 PLPP1 PNLIPRP3 PNLIPRP3 PLA2G3 PLA2G3 PAFAH1B3 PAFAH1B3 CYP4F2 CYP4F2 GDPD3 GDPD3 PLD3 PLD3 CIDEC CIDEC MOGAT2 MOGAT2 LPCAT2 LPCAT2 PLAAT3 PLAAT3 LPCAT4 LPCAT4 GPAM GPAM CRLS1 CRLS1 ALOX5AP ALOX5AP GPD1L GPD1L MGLL MGLL PGS1 PGS1 PTGIS PTGIS PLA2G5 PLA2G5 LOC102130440 LOC102130440 PLA2G4B PLA2G4B PLA2G12B PLA2G12B LPIN1 LPIN1 LIPF LIPF DGAT2 DGAT2 PTPMT1 PTPMT1 LTC4S LTC4S LYPLA1 LYPLA1 PLA2G4A PLA2G4A ENSMFAP00000024569 ENSMFAP00000024569 ENSMFAP00000024835 ENSMFAP00000024835 C17orf67 C17orf67 CEPT1 CEPT1 SELENOI SELENOI PLPP2 PLPP2 HPGDS HPGDS ALOX15 ALOX15 PLA2G2C PLA2G2C PNPLA2 PNPLA2 CHPT1 CHPT1 PLA2G1B PLA2G1B PLA2G4E PLA2G4E PTGES3 PTGES3 LIPC LIPC AGPAT4 AGPAT4 TRIM13 TRIM13 ADPRM ADPRM GPAT2 GPAT2 CEL CEL AGPAT1 AGPAT1 LCLAT1 LCLAT1 GPR17 GPR17 PLA2G10 PLA2G10 PLA2G2D PLA2G2D GPCPD1 GPCPD1 ENPP2 ENPP2 ALOX15B ALOX15B LOC102137290 LOC102137290 PLD1 PLD1 PLD2 PLD2 CYP2J2 CYP2J2 GPAT4 GPAT4 MBOAT2 MBOAT2 PTGDS PTGDS CYP2U1 CYP2U1 DGAT1 DGAT1 PLA2G4D PLA2G4D PLPP5 PLPP5 CDIPT CDIPT AGPAT2 AGPAT2 PLIN1 PLIN1 PAFAH2 PAFAH2 PTGES PTGES TMEM189 TMEM189 PLA2G4F PLA2G4F LPIN2 LPIN2 ABHD5 ABHD5 ENPP6 ENPP6 PEMT PEMT DGKA DGKA PLA2G6 PLA2G6 PTGS1 PTGS1 PLA2G2A PLA2G2A PRXL2B PRXL2B CYP4F8 CYP4F8 HPGD HPGD COTL1 COTL1 AGK AGK PLA2G2F PLA2G2F PLA2G15 PLA2G15 ENSMFAP00000043174 ENSMFAP00000043174 ALOX12 ALOX12 PLIN5 PLIN5 CDS2 CDS2 GPAT3 GPAT3 LPCAT1 LPCAT1 PNLIPRP2 PNLIPRP2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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DGKEDiacylglycerol kinase. (567 aa)
PNPLA8Patatin like phospholipase domain containing 8. (782 aa)
MOGAT3Monoacylglycerol O-acyltransferase 3. (341 aa)
AGPAT51-acylglycerol-3-phosphate O-acyltransferase 5. (364 aa)
PLD4Phospholipase D family member 4. (506 aa)
LYPLA2Lysophospholipase 2. (276 aa)
PLPP4Phospholipid phosphatase 4. (271 aa)
LPIN3Lipin 3. (852 aa)
LIPGLipase G, endothelial type. (500 aa)
PLA2G12APhospholipase A2 group XIIA. (189 aa)
TMEM86BTransmembrane protein 86B. (226 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (487 aa)
PLA2G2EPhospholipase A(2). (142 aa)
PLA2G7Platelet-activating factor acetylhydrolase. (439 aa)
AGPAT31-acylglycerol-3-phosphate O-acyltransferase 3. (376 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (461 aa)
PNLIPTriacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (465 aa)
MBOAT1Membrane bound O-acyltransferase domain containing 1; Belongs to the membrane-bound acyltransferase family. (495 aa)
PTGES2Prostaglandin E synthase 2 truncated form; Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2); Belongs to the GST superfamily. (377 aa)
GDPD1Glycerophosphodiester phosphodiesterase domain containing 1. (314 aa)
PTDSS1Phosphatidylserine synthase 1. (473 aa)
PLB1Phospholipase B1. (1461 aa)
PNPLA3Patatin like phospholipase domain containing 3. (507 aa)
TAMM41Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. (442 aa)
FADS2Acyl-CoA 6-desaturase; Acts as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic [...] (444 aa)
ALOXE3Arachidonate lipoxygenase 3. (711 aa)
MOGAT1Monoacylglycerol O-acyltransferase 1. (335 aa)
ALOX12BLipoxygenase domain-containing protein. (235 aa)
PISDPhosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (409 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (370 aa)
LTA4HLeukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (611 aa)
PAFAH1B2Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (229 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
PLPP3acidPPc domain-containing protein. (353 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (414 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
TAZTafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (292 aa)
AKAP9A-kinase anchoring protein 9. (3909 aa)
PLPP1Phospholipid phosphatase 1. (285 aa)
PNLIPRP3Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (473 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
PAFAH1B3Platelet activating factor acetylhydrolase 1b catalytic subunit 3. (232 aa)
CYP4F2Cytochrome P450 family 4 subfamily F member 2; Belongs to the cytochrome P450 family. (502 aa)
GDPD3Glycerophosphodiester phosphodiesterase domain containing 3. (318 aa)
PLD35'-3' exonuclease PLD3; 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity). (490 aa)
CIDECCell death inducing DFFA like effector c. (251 aa)
MOGAT2Monoacylglycerol O-acyltransferase 2. (334 aa)
LPCAT2Uncharacterized protein. (544 aa)
PLAAT3Phospholipase A and acyltransferase 3. (162 aa)
LPCAT4Lysophosphatidylcholine acyltransferase 4. (524 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
CRLS1Cardiolipin synthase 1. (301 aa)
ALOX5APArachidonate 5-lipoxygenase-activating protein; Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity); Belongs to the MAPEG family. (217 aa)
GPD1LGlycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa)
MGLLMonoglyceride lipase. (378 aa)
PGS1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. (556 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
PLA2G5Phospholipase A(2). (138 aa)
LOC102130440Uncharacterized protein; Belongs to the cytochrome P450 family. (520 aa)
PLA2G4BPhospholipase A2. (781 aa)
PLA2G12BPhospholipase A2 group XIIB. (195 aa)
LPIN1Lipin 1. (975 aa)
LIPFLipase; Belongs to the AB hydrolase superfamily. Lipase family. (408 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
PTPMT1Protein tyrosine phosphatase mitochondrial 1. (201 aa)
LTC4SLeukotriene C4 synthase. (150 aa)
LYPLA1Lysophospholipase 1. (230 aa)
PLA2G4APhospholipase A2. (749 aa)
ENSMFAP00000024569SGNH_hydro domain-containing protein. (253 aa)
ENSMFAP00000024835Uncharacterized protein. (120 aa)
C17orf67Chromosome 17 open reading frame 67. (90 aa)
CEPT1Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (416 aa)
SELENOISelenoprotein I; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (386 aa)
PLPP2Phospholipid phosphatase 2. (302 aa)
HPGDSHematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa)
ALOX15Arachidonate 15-lipoxygenase. (662 aa)
PLA2G2CPhospholipase A(2). (151 aa)
PNPLA2Patatin like phospholipase domain containing 2. (484 aa)
CHPT1Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (346 aa)
PLA2G1BPhospholipase A(2). (148 aa)
PLA2G4EPhospholipase A2. (869 aa)
PTGES3Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway; Belongs to the p23/wos2 family. (162 aa)
LIPCLipase C, hepatic type. (523 aa)
AGPAT41-acyl-sn-glycerol-3-phosphate acyltransferase delta; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity). (378 aa)
TRIM13Tripartite motif containing 13. (409 aa)
ADPRMADP-ribose/CDP-alcohol diphosphatase, manganese dependent. (342 aa)
GPAT2Glycerol-3-phosphate acyltransferase 2, mitochondrial. (795 aa)
CELCarboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family. (734 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (283 aa)
LCLAT1Lysocardiolipin acyltransferase 1. (397 aa)
GPR17G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (371 aa)
PLA2G10Phospholipase A(2). (165 aa)
PLA2G2DPhospholipase A(2). (161 aa)
GPCPD1Glycerophosphocholine phosphodiesterase 1. (672 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (915 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (676 aa)
LOC102137290Uncharacterized protein. (643 aa)
PLD1Phospholipase. (1074 aa)
PLD2Phospholipase. (933 aa)
CYP2J2Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (502 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4. (456 aa)
MBOAT2Membrane bound O-acyltransferase domain containing 2; Belongs to the membrane-bound acyltransferase family. (520 aa)
PTGDSLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
CYP2U1Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (544 aa)
DGAT1O-acyltransferase. (491 aa)
PLA2G4DPhospholipase A2. (817 aa)
PLPP5Phospholipid phosphatase 5. (265 aa)
CDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (278 aa)
PLIN1Perilipin; Belongs to the perilipin family. (522 aa)
PAFAH2Platelet-activating factor acetylhydrolase. (392 aa)
PTGESProstaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). (163 aa)
TMEM189TMEM189_B_dmain domain-containing protein. (270 aa)
PLA2G4FPhospholipase A2. (849 aa)
LPIN2Lipin 2. (933 aa)
ABHD5Abhydrolase domain containing 5. (349 aa)
ENPP6Ectonucleotide pyrophosphatase/phosphodiesterase 6. (440 aa)
PEMTPhosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. (236 aa)
DGKADiacylglycerol kinase. (735 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (632 aa)
PLA2G2APhospholipase A(2). (144 aa)
PRXL2BPeroxiredoxin like 2B. (223 aa)
CYP4F8Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family. (520 aa)
HPGD15-hydroxyprostaglandin dehydrogenase [NAD(+)]; Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
COTL1Coactosin like F-actin binding protein 1. (142 aa)
AGKAcylglycerol kinase. (422 aa)
PLA2G2FPhospholipase A(2). (199 aa)
PLA2G15Phospholipase A2 group XV. (412 aa)
ENSMFAP00000043174Uncharacterized protein. (390 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
PLIN5Perilipin; Belongs to the perilipin family. (462 aa)
CDS2Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (445 aa)
GPAT3PlsC domain-containing protein. (356 aa)
LPCAT1Lysophosphatidylcholine acyltransferase 1. (534 aa)
PNLIPRP2Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (469 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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