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SPTLC2 SPTLC2 DEGS1 DEGS1 ENPP7 ENPP7 SGMS1 SGMS1 SMPD3 SMPD3 GALC GALC SPTSSA SPTSSA SPHK2 SPHK2 KDSR KDSR GBA GBA ORMDL3 ORMDL3 SPTLC1 SPTLC1 SPTSSB SPTSSB SGPP2 SGPP2 SPHK1 SPHK1 SMPD2 SMPD2 UGT8 UGT8 SMPD1 SMPD1 ACER1 ACER1 DEGS2 DEGS2 ORMDL2 ORMDL2 CERS3 CERS3 CERS4 CERS4 SPTLC3 SPTLC3 CERS1 CERS1 GBA2 GBA2 SGPP1 SGPP1 ACER2 ACER2 ASAH2 ASAH2 CERS2 CERS2 UGCG UGCG CERK CERK CERS6 CERS6 ACER3 ACER3 SGMS2 SGMS2 ISM2 ISM2 ASAH1 ASAH1 SGPL1 SGPL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SPTLC2Serine palmitoyltransferase long chain base subunit 2. (555 aa)
DEGS1Delta 4-desaturase, sphingolipid 1. (323 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (458 aa)
SGMS1Sphingomyelin synthase 1. (419 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
GALCGalactosylceramidase. (685 aa)
SPTSSASerine palmitoyltransferase small subunit A. (71 aa)
SPHK2Sphingosine kinase 2. (653 aa)
KDSR3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa)
GBAGlucosylceramidase. (533 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
SPTLC1Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] (500 aa)
SPTSSBSerine palmitoyltransferase small subunit B. (76 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (399 aa)
SPHK1Sphingosine kinase 1. (470 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (423 aa)
UGT8UDP glycosyltransferase 8; Belongs to the UDP-glycosyltransferase family. (541 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (629 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (323 aa)
ORMDL2ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
CERS3Ceramide synthase 3. (385 aa)
CERS4Ceramide synthase 4. (394 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (552 aa)
CERS1TLC domain-containing protein. (337 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (927 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (441 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
ASAH2Neutral ceramidase. (780 aa)
CERS2Ceramide synthase 2. (380 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (394 aa)
CERKCeramide kinase. (537 aa)
CERS6Ceramide synthase 6. (392 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)
SGMS2Phosphatidylcholine:ceramide cholinephosphotransferase 2; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signa [...] (365 aa)
ISM2Isthmin 2. (489 aa)
ASAH1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] (411 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (560 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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