STRINGSTRING
PTRHD1 PTRHD1 AVP AVP PTGER4 PTGER4 GABBR1 GABBR1 PLCB4 PLCB4 LPAR6 LPAR6 GNGT1 GNGT1 LPAR2 LPAR2 AVPR1B AVPR1B ARHGEF12 ARHGEF12 CXCL8 CXCL8 GNA13 GNA13 GNG13 GNG13 ENSMFAP00000004742 ENSMFAP00000004742 ENSMFAP00000005412 ENSMFAP00000005412 ENSMFAP00000006047 ENSMFAP00000006047 RGS16 RGS16 MTNR1A MTNR1A RGS4 RGS4 PTGER2 PTGER2 GNAI1 GNAI1 HTR7 HTR7 GNGT2 GNGT2 ADORA1 ADORA1 ENSMFAP00000009633 ENSMFAP00000009633 S1PR4 S1PR4 S1PR3 S1PR3 P2RY1 P2RY1 ADORA2B ADORA2B CHRM5 CHRM5 S1PR1 S1PR1 CHRM4 CHRM4 LPAR4 LPAR4 BDKRB2 BDKRB2 CYSLTR2 CYSLTR2 CHRM1 CHRM1 CHRM2 CHRM2 CYSLTR1 CYSLTR1 GNB3 GNB3 RGS9BP RGS9BP APLNR APLNR KCNJ9 KCNJ9 ADRA1A ADRA1A RGS7 RGS7 AKAP13 AKAP13 APELA APELA ADORA2A ADORA2A HTR6 HTR6 LPAR1-2 LPAR1-2 GNAO1 GNAO1 GNAI2 GNAI2 RGS13 RGS13 RGS18 RGS18 RGS6 RGS6 RIC8A RIC8A RGS10 RGS10 RGS21 RGS21 KCNJ3 KCNJ3 GNA14 GNA14 PLEKHG5 PLEKHG5 PLCB1 PLCB1 GNAS GNAS AVPR2 AVPR2 GNG8 GNG8 F2R F2R PLCB3 PLCB3 ADRA1B ADRA1B RGS7BP RGS7BP HEXD HEXD GPR150 GPR150 KCNJ5 KCNJ5 GPR158 GPR158 GABBR2 GABBR2 RGS5 RGS5 PDCL PDCL RGS1 RGS1 GNB5 GNB5 ADRA2C ADRA2C ADRA1D ADRA1D GNG7 GNG7 GNAQ GNAQ AVPR1A AVPR1A RGS11 RGS11 GRM5 GRM5 OPRD1 OPRD1 GNG2 GNG2 GNAI3 GNAI3 GPRC6A GPRC6A LPAR3 LPAR3 ARHGEF11 ARHGEF11 DRD4 DRD4 RGS14 RGS14 GNA12 GNA12 RGS3 RGS3 KNG1 KNG1 PTGFR PTGFR GNA11 GNA11 GNB4 GNB4 GNG10 GNG10 CASR CASR OXT OXT PTGER1 PTGER1 GNB1 GNB1 RGS9 RGS9 GNB2 GNB2 GNG3 GNG3 RGS17 RGS17 KCNJ6 KCNJ6 GRK4 GRK4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
PTGER4Prostaglandin E2 subtype EP4 receptor; Belongs to the G-protein coupled receptor 1 family. (490 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (1011 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
LPAR2Lysophosphatidic acid receptor 2; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (By similarity). (351 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
GNA13G protein subunit alpha 13. (377 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
ENSMFAP00000004742G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (347 aa)
ENSMFAP00000005412Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ENSMFAP00000006047Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
RGS16Regulator of G protein signaling 16. (202 aa)
MTNR1AMelatonin receptor 1A; Belongs to the G-protein coupled receptor 1 family. (352 aa)
RGS4Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)- alpha-1 is inhibited by palmitoylation of the G-protein (By similarity). (302 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (393 aa)
GNAI1G protein subunit alpha i1. (422 aa)
HTR75-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (480 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
ENSMFAP00000009633Uncharacterized protein. (245 aa)
S1PR4Sphingosine-1-phosphate receptor 4. (384 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (394 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (479 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
CYSLTR2Cysteinyl leukotriene receptor 2. (332 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
CYSLTR1Cysteinyl leukotriene receptor 1. (337 aa)
GNB3G protein subunit beta 3. (340 aa)
RGS9BPRegulator of G protein signaling 9 binding protein. (235 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (397 aa)
ADRA1AAdrenoceptor alpha 1A. (462 aa)
RGS7Regulator of G protein signaling 7. (487 aa)
AKAP13A-kinase anchoring protein 13. (2818 aa)
APELAUncharacterized protein. (54 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (440 aa)
LPAR1-2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (378 aa)
GNAO1G protein subunit alpha o1. (354 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
RGS13Regulator of G protein signaling 13. (159 aa)
RGS18Regulator of G protein signaling 18. (235 aa)
RGS6Regulator of G protein signaling 6. (538 aa)
RIC8ASynembryn-A; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)- alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity). (530 aa)
RGS10Regulator of G protein signaling 10. (181 aa)
RGS21Regulator of G protein signaling 21. (152 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
GNA14G protein subunit alpha 14. (355 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1154 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNASGNAS complex locus. (1023 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (368 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa)
ADRA1BAdrenoceptor alpha 1B. (518 aa)
RGS7BPRegulator of G protein signaling 7 binding protein. (257 aa)
HEXDHexosaminidase D. (575 aa)
GPR150G protein-coupled receptor 150. (435 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (432 aa)
GPR158G protein-coupled receptor 158. (1214 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (883 aa)
RGS5RGS domain-containing protein. (201 aa)
PDCLPhosducin like. (301 aa)
RGS1Regulator of G protein signaling 1. (209 aa)
GNB5G protein subunit beta 5. (409 aa)
ADRA2CAdrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family. (365 aa)
ADRA1DAdrenoceptor alpha 1D. (462 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAQG protein subunit alpha q. (359 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
RGS11Regulator of G protein signaling 11. (469 aa)
GRM5Glutamate metabotropic receptor 5. (1212 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
GNAI3G protein subunit alpha i3. (354 aa)
GPRC6AG protein-coupled receptor class C group 6 member A. (928 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1573 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (415 aa)
RGS14Regulator of G protein signaling 14. (566 aa)
GNA12G protein subunit alpha 12. (381 aa)
RGS3Regulator of G protein signaling 3. (916 aa)
KNG1Kininogen 1. (644 aa)
PTGFRProstaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
GNA11G protein subunit alpha 11. (359 aa)
GNB4G protein subunit beta 4. (340 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CASRCalcium sensing receptor. (1078 aa)
OXTUncharacterized protein; Belongs to the vasopressin/oxytocin family. (153 aa)
PTGER1Prostaglandin E receptor 1. (402 aa)
GNB1G protein subunit beta 1. (340 aa)
RGS9Regulator of G protein signaling 9. (654 aa)
GNB2WD_REPEATS_REGION domain-containing protein. (375 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RGS17Regulator of G-protein signaling 17. (210 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
GRK4G protein-coupled receptor kinase 4. (540 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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