node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HMGCR | HMGCS1 | ENSMFAP00000007859 | ENSMFAP00000001412 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.998 |
HMGCR | MVD | ENSMFAP00000007859 | ENSMFAP00000045772 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 0.835 |
HMGCR | MVK | ENSMFAP00000007859 | ENSMFAP00000033102 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.995 |
HMGCR | PMVK | ENSMFAP00000007859 | ENSMFAP00000018784 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | Phosphomevalonate kinase. | 0.753 |
HMGCS1 | HMGCR | ENSMFAP00000001412 | ENSMFAP00000007859 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 0.998 |
HMGCS1 | MVD | ENSMFAP00000001412 | ENSMFAP00000045772 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 0.828 |
HMGCS1 | MVK | ENSMFAP00000001412 | ENSMFAP00000033102 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.831 |
HMGCS1 | PMVK | ENSMFAP00000001412 | ENSMFAP00000018784 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Phosphomevalonate kinase. | 0.529 |
MVD | HMGCR | ENSMFAP00000045772 | ENSMFAP00000007859 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 0.835 |
MVD | HMGCS1 | ENSMFAP00000045772 | ENSMFAP00000001412 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.828 |
MVD | MVK | ENSMFAP00000045772 | ENSMFAP00000033102 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.996 |
MVD | PMVK | ENSMFAP00000045772 | ENSMFAP00000018784 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | Phosphomevalonate kinase. | 0.945 |
MVK | HMGCR | ENSMFAP00000033102 | ENSMFAP00000007859 | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 0.995 |
MVK | HMGCS1 | ENSMFAP00000033102 | ENSMFAP00000001412 | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.831 |
MVK | MVD | ENSMFAP00000033102 | ENSMFAP00000045772 | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 0.996 |
MVK | PMVK | ENSMFAP00000033102 | ENSMFAP00000018784 | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | Phosphomevalonate kinase. | 0.915 |
PMVK | HMGCR | ENSMFAP00000018784 | ENSMFAP00000007859 | Phosphomevalonate kinase. | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 0.753 |
PMVK | HMGCS1 | ENSMFAP00000018784 | ENSMFAP00000001412 | Phosphomevalonate kinase. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.529 |
PMVK | MVD | ENSMFAP00000018784 | ENSMFAP00000045772 | Phosphomevalonate kinase. | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 0.945 |
PMVK | MVK | ENSMFAP00000018784 | ENSMFAP00000033102 | Phosphomevalonate kinase. | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.915 |