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| | STIP1 | Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. (649 aa) |
| | ENSMFAP00000000762 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (578 aa) |
| | AIP | Peptidylprolyl isomerase. (330 aa) |
| | NR3C1 | Nuclear receptor subfamily 3 group C member 1. (778 aa) |
| | ENSMFAP00000000934 | Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (503 aa) |
| | TYSND1 | Trypsin domain containing 1. (566 aa) |
| | ENSMFAP00000003043 | J domain-containing protein. (225 aa) |
| | HYOU1 | Hypoxia up-regulated 1. (999 aa) |
| | DNAJC5B | DnaJ heat shock protein family (Hsp40) member C5 beta. (199 aa) |
| | SECISBP2L | SECIS binding protein 2 like. (1101 aa) |
| | DNAJB9 | J domain-containing protein. (222 aa) |
| | ENSMFAP00000006110 | Uncharacterized protein. (373 aa) |
| | EDEM1 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (657 aa) |
| | CDC37 | Cell division cycle 37. (378 aa) |
| | NR3C2 | Nuclear receptor subfamily 3 group C member 2. (988 aa) |
| | ENSMFAP00000008080 | Uncharacterized protein. (438 aa) |
| | ERO1A | Endoplasmic reticulum oxidoreductase 1 alpha. (468 aa) |
| | PLAAT4 | Phospholipase A and acyltransferase 4. (156 aa) |
| | ERP29 | Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa) |
| | G7PJL0_MACFA | Uncharacterized protein; Belongs to the GroES chaperonin family. (102 aa) |
| | ENSMFAP00000011810 | Uncharacterized protein. (370 aa) |
| | HSPH1 | Heat shock protein family H (Hsp110) member 1. (978 aa) |
| | ENSMFAP00000012410 | Uncharacterized protein; Belongs to the GroES chaperonin family. (102 aa) |
| | ENSMFAP00000012436 | Uncharacterized protein. (370 aa) |
| | DNAJC22 | DnaJ heat shock protein family (Hsp40) member C22. (307 aa) |
| | ENSMFAP00000013271 | Uncharacterized protein. (70 aa) |
| | HSPA4 | Heat shock protein family A (Hsp70) member 4. (840 aa) |
| | LONP2 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (825 aa) |
| | FKBP5 | Peptidylprolyl isomerase. (457 aa) |
| | ENSMFAP00000014199 | HATPase_c domain-containing protein. (307 aa) |
| | ENSMFAP00000014202 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (571 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2 alpha kinase 2. (554 aa) |
| | PDIA5 | Protein disulfide isomerase family A member 5. (519 aa) |
| | ENSMFAP00000015252 | Uncharacterized protein. (256 aa) |
| | DNAJA4 | DnaJ heat shock protein family (Hsp40) member A4. (426 aa) |
| | ENSMFAP00000015734 | Uncharacterized protein. (348 aa) |
| | ENSMFAP00000015786 | Uncharacterized protein. (484 aa) |
| | ENSMFAP00000016154 | CS domain-containing protein. (155 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa) |
| | AIPL1 | Aryl hydrocarbon receptor interacting protein like 1. (401 aa) |
| | DNAJC7 | Uncharacterized protein. (545 aa) |
| | CANX | Calnexin. (592 aa) |
| | DNAJA1 | Uncharacterized protein. (397 aa) |
| | CLPX | Caseinolytic mitochondrial matrix peptidase chaperone subunit. (633 aa) |
| | ENSMFAP00000018412 | HATPase_c domain-containing protein. (644 aa) |
| | EDEM3 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (948 aa) |
| | DNAJB5 | DnaJ heat shock protein family (Hsp40) member B5. (462 aa) |
| | ENSMFAP00000018887 | Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (315 aa) |
| | HSPD1 | Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (598 aa) |
| | DNAJC10 | DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (793 aa) |
| | SDF2L1 | Stromal cell derived factor 2 like 1. (221 aa) |
| | SIL1 | SIL1 nucleotide exchange factor. (468 aa) |
| | AHR | Uncharacterized protein. (850 aa) |
| | ENSMFAP00000021941 | Uncharacterized protein. (362 aa) |
| | DNAJB13 | DnaJ heat shock protein family (Hsp40) member B13. (316 aa) |
| | AHRR | Uncharacterized protein. (718 aa) |
| | ENSMFAP00000022812 | Uncharacterized protein. (421 aa) |
| | HSPA2 | Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (641 aa) |
| | ENSMFAP00000022974 | DnaJ_C domain-containing protein. (213 aa) |
| | DNAJB12 | DnaJ heat shock protein family (Hsp40) member B12. (409 aa) |
| | LONP1 | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (961 aa) |
| | UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2. (1518 aa) |
| | BAG2 | BAG domain-containing protein. (211 aa) |
| | HSPA14 | Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding- competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity). (509 aa) |
| | MANF | Mesencephalic astrocyte derived neurotrophic factor. (182 aa) |
| | GRPEL2 | GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (225 aa) |
| | CLGN | Calmegin. (619 aa) |
| | HSPBP1 | Hsp70-binding protein 1; Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity). (364 aa) |
| | DNAJC2 | DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histo [...] (621 aa) |
| | BAG1 | BCL2 associated athanogene 1. (345 aa) |
| | LOC102147033 | Uncharacterized protein; Belongs to the GroES chaperonin family. (108 aa) |
| | HSPA13 | Heat shock protein family A (Hsp70) member 13. (471 aa) |
| | ERO1B | Endoplasmic reticulum oxidoreductase 1 beta. (467 aa) |
| | ENSMFAP00000028227 | DnaJ_C domain-containing protein. (291 aa) |
| | ENSMFAP00000029034 | Uncharacterized protein; Belongs to the GroES chaperonin family. (88 aa) |
| | ENSMFAP00000029382 | Uncharacterized protein. (45 aa) |
| | CRELD2 | Cysteine rich with EGF like domains 2. (415 aa) |
| | HSPA12B | Heat shock protein family A (Hsp70) member 12B. (686 aa) |
| | AHSA2P | Aha1_N domain-containing protein. (334 aa) |
| | DNAJB1 | DnaJ heat shock protein family (Hsp40) member B1. (340 aa) |
| | PGR | Progesterone receptor. (936 aa) |
| | DNAJA3 | DnaJ heat shock protein family (Hsp40) member A3. (480 aa) |
| | AR | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (895 aa) |
| | CLPP | Uncharacterized protein. (56 aa) |
| | DNAJB6 | DnaJ homolog subfamily B member 6; Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose- dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). (334 aa) |
| | PLAAT2 | Phospholipase A and acyltransferase 2. (164 aa) |
| | ENSMFAP00000031500 | Uncharacterized protein. (461 aa) |
| | TTC9C | Tetratricopeptide repeat protein 9C; Belongs to the TTC9 family. (171 aa) |
| | HSP90B1 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. (804 aa) |
| | DNAJB14 | DnaJ heat shock protein family (Hsp40) member B14. (379 aa) |
| | ENSMFAP00000032209 | Uncharacterized protein; Belongs to the GrpE family. (216 aa) |
| | ENSMFAP00000032511 | Uncharacterized protein. (372 aa) |
| | HSP90AA1 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (831 aa) |
| | HSPA4L | Heat shock protein family A (Hsp70) member 4 like. (840 aa) |
| | ENSMFAP00000033774 | Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (551 aa) |
| | DNAJA2 | DnaJ heat shock protein family (Hsp40) member A2. (412 aa) |
| | ANKRD45 | ANK_REP_REGION domain-containing protein. (266 aa) |
| | EDEM2 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa) |
| | UGGT1 | UDP-glucose glycoprotein glucosyltransferase 1. (1556 aa) |
| | AARSD1 | Uncharacterized protein. (585 aa) |
| | DNAJC3 | DnaJ heat shock protein family (Hsp40) member C3. (504 aa) |
| | HSPA6 | Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (600 aa) |
| | HSPA12A | Heat shock protein family A (Hsp70) member 12A. (693 aa) |
| | ENSMFAP00000036905 | Uncharacterized protein. (238 aa) |
| | ENSMFAP00000037561 | Uncharacterized protein. (115 aa) |
| | PDIA4 | Protein disulfide-isomerase A4. (644 aa) |
| | HSP90AB1 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (724 aa) |
| | ENSMFAP00000038713 | CS domain-containing protein. (154 aa) |
| | HSPA8 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa) |
| | DNAJC5G | DnaJ heat shock protein family (Hsp40) member C5 gamma. (189 aa) |
| | P4HB | Protein disulfide-isomerase. (510 aa) |
| | BAG5 | BCL2 associated athanogene 5. (488 aa) |
| | PPIG | Peptidylprolyl isomerase G. (754 aa) |
| | ENSMFAP00000041402 | Uncharacterized protein. (155 aa) |
| | HSPA5 | Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa) |
| | ENSMFAP00000042061 | Uncharacterized protein. (97 aa) |
| | ENSMFAP00000042433 | Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (508 aa) |
| | ENSMFAP00000042475 | Uncharacterized protein. (290 aa) |
| | ENSMFAP00000042652 | Uncharacterized protein; Belongs to the GroES chaperonin family. (95 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (978 aa) |
| | DNAJC25 | DnaJ heat shock protein family (Hsp40) member C25. (360 aa) |
| | DNAJB11 | J domain-containing protein. (358 aa) |
| | PPP5C | Serine/threonine-protein phosphatase. (510 aa) |
| | GRPEL1 | GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (217 aa) |
| | ENSMFAP00000043889 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (619 aa) |
| | ENSMFAP00000043943 | Uncharacterized protein. (65 aa) |
| | PLAAT1 | Phospholipase A and acyltransferase 1. (271 aa) |
| | AHSA1 | Activator of HSP90 ATPase activity 1. (338 aa) |
| | CLPB | ANK_REP_REGION domain-containing protein. (704 aa) |
| | PDIA6 | Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. (492 aa) |
| | EIF2AK1 | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser- 51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] (631 aa) |
| | HSPA1L | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] (643 aa) |
| | FKBP4 | Peptidylprolyl isomerase. (459 aa) |
| | ENSMFAP00000045795 | Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (209 aa) |
