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| | ENSMFAP00000000527 | Sld5 domain-containing protein. (151 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3127 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (642 aa) |
| | MSH5 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (833 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (584 aa) |
| | DNA2 | Uncharacterized protein. (948 aa) |
| | DCLRE1A | DNA cross-link repair 1A. (1039 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (466 aa) |
| | POLA1 | DNA polymerase. (1478 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1622 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (277 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (898 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (323 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (273 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | TM4SF19 | Uncharacterized protein. (311 aa) |
| | ENSMFAP00000004513 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (934 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (341 aa) |
| | RAD51C | RAD51 paralog C. (370 aa) |
| | BIVM | BIVM-ERCC5 readthrough. (1638 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (533 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa) |
| | ENSMFAP00000006564 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (269 aa) |
| | ENSMFAP00000007027 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (506 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa) |
| | ENSMFAP00000007488 | RPA_C domain-containing protein. (223 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1820 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | ENSMFAP00000007997 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (189 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (419 aa) |
| | MLH1 | MutL homolog 1. (756 aa) |
| | ENSMFAP00000009642 | Uncharacterized protein. (88 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (267 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | POLD1 | DNA polymerase. (1107 aa) |
| | TDRD3 | Tudor domain containing 3. (744 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | POLI | DNA polymerase iota. (659 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (280 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | LIG1 | DNA ligase. (919 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | EXO1 | Exonuclease 1. (846 aa) |
| | PIEZO1 | Piezo-type mechanosensitive ion channel component. (2525 aa) |
| | CLSPN | Claspin. (1341 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (900 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (379 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | TIMELESS | Timeless circadian regulator. (1206 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | ENSMFAP00000014864 | Uncharacterized protein. (88 aa) |
| | ENSMFAP00000015147 | Uncharacterized protein. (84 aa) |
| | ENSMFAP00000015231 | Uncharacterized protein. (118 aa) |
| | NBN | Nibrin. (754 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (877 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | FSBP | Uncharacterized protein. (908 aa) |
| | GINS3 | GINS complex subunit 3. (255 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (307 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (898 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1017 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1127 aa) |
| | ENSMFAP00000020152 | Protein kinase domain-containing protein. (535 aa) |
| | ENSMFAP00000020733 | Uncharacterized protein. (103 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (1003 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1496 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | ENSMFAP00000022440 | Uncharacterized protein. (248 aa) |
| | BLM | BLM RecQ like helicase. (1416 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (774 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | POLK | DNA polymerase kappa. (870 aa) |
| | WRN | WRN RecQ like helicase. (1428 aa) |
| | RAD51B | RAD51 paralog B. (425 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1250 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1124 aa) |
| | MLH3 | MutL homolog 3. (1456 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1817 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (450 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1247 aa) |
| | RFC5 | Replication factor C subunit 5. (343 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) |
| | BRCA1 | Uncharacterized protein. (1884 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (880 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (347 aa) |
| | POLH | DNA polymerase eta. (712 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | RFC3 | Replication factor C subunit 3/5. (356 aa) |
| | ORC3 | Origin recognition complex subunit 3. (712 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3418 aa) |
| | RFC1 | Replication factor C subunit 1. (1148 aa) |
| | RPA3 | Uncharacterized protein. (121 aa) |
| | CHTF8 | Chromosome transmission fidelity factor 8. (121 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa) |
| | POLD2 | Uncharacterized protein. (504 aa) |
| | RAD51D | RAD51 paralog D. (347 aa) |
| | PCNA | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] (261 aa) |
| | PMS1 | PMS1 homolog 1, mismatch repair system component. (931 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | PALB2 | PALB2_WD40 domain-containing protein. (623 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (429 aa) |
| | ATRIP | ATR-interacting protein; Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein (By similarity). (791 aa) |
| | ENSMFAP00000035495 | Uncharacterized protein. (275 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (949 aa) |
| | DBF4 | DBF4 zinc finger. (675 aa) |
| | RHNO1 | Uncharacterized protein. (226 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (117 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | MSH4 | MutS homolog 4. (935 aa) |
| | CDC45 | Cell division cycle 45. (598 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (681 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (828 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | DBF4B | DBF4 zinc finger B. (535 aa) |
| | RAD9A | Cell cycle checkpoint control protein RAD9A; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN [...] (390 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (620 aa) |
| | MRE11 | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] (707 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (370 aa) |
| | ENSMFAP00000044257 | Uncharacterized protein. (83 aa) |
| | ENSMFAP00000044831 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (577 aa) |
| | FANCM | FA complementation group M. (2050 aa) |
| | CDC7 | Protein kinase domain-containing protein. (574 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...] (471 aa) |
