STRINGSTRING
ENSMFAP00000000527 ENSMFAP00000000527 REV3L REV3L MCMBP MCMBP MSH5 MSH5 EME1 EME1 DNA2 DNA2 DCLRE1A DCLRE1A ORC1 ORC1 POLD3 POLD3 POLA1 POLA1 TOPBP1 TOPBP1 HUS1B HUS1B MSH2 MSH2 ERCC1 ERCC1 XPA XPA MCM3 MCM3 TM4SF19 TM4SF19 ENSMFAP00000004513 ENSMFAP00000004513 GEN1 GEN1 SLX1A SLX1A RAD51C RAD51C BIVM BIVM GINS2 GINS2 POLE2 POLE2 ORC5 ORC5 ORC2 ORC2 RAD9B RAD9B ENSMFAP00000006564 ENSMFAP00000006564 ENSMFAP00000007027 ENSMFAP00000007027 TOP3B TOP3B ENSMFAP00000007488 ENSMFAP00000007488 ATAD5 ATAD5 MSH6 MSH6 HUS1 HUS1 ENSMFAP00000007997 ENSMFAP00000007997 MUS81 MUS81 ATR ATR RAD52 RAD52 MLH1 MLH1 ENSMFAP00000009642 ENSMFAP00000009642 RPA1 RPA1 ORC6 ORC6 POLD1 POLD1 TDRD3 TDRD3 FEN1 FEN1 POLI POLI RAD1 RAD1 RMI1 RMI1 LIG1 LIG1 RPA2 RPA2 EXO1 EXO1 PIEZO1 PIEZO1 CLSPN CLSPN MCM2 MCM2 EME2 EME2 SLF1 SLF1 TIMELESS TIMELESS RFC4 RFC4 POLE3 POLE3 ENSMFAP00000014864 ENSMFAP00000014864 ENSMFAP00000015147 ENSMFAP00000015147 ENSMFAP00000015231 ENSMFAP00000015231 NBN NBN RAD17 RAD17 MCM10 MCM10 RAD54L RAD54L POLA2 POLA2 ORC4 ORC4 FSBP FSBP GINS3 GINS3 RMI2 RMI2 TIPIN TIPIN RBBP8 RBBP8 BARD1 BARD1 FAN1 FAN1 PRIM2 PRIM2 WDHD1 WDHD1 ENSMFAP00000020152 ENSMFAP00000020152 ENSMFAP00000020733 ENSMFAP00000020733 CHTF18 CHTF18 MCM4 MCM4 ERCC6 ERCC6 RECQL4 RECQL4 ATM ATM ENSMFAP00000022440 ENSMFAP00000022440 BLM BLM RFWD3 RFWD3 ERCC4 ERCC4 POLK POLK WRN WRN RAD51B RAD51B REV1 REV1 MSH3 MSH3 MLH3 MLH3 SLX4 SLX4 CDT1 CDT1 MCM7 MCM7 TOP3A TOP3A BRIP1 BRIP1 RFC5 RFC5 CDC6 CDC6 BRCA1 BRCA1 MCM8 MCM8 RECQL5 RECQL5 RAD51 RAD51 XRCC3 XRCC3 POLH POLH XRCC2 XRCC2 RFC3 RFC3 ORC3 ORC3 BRCA2 BRCA2 RFC1 RFC1 RPA3 RPA3 CHTF8 CHTF8 PIF1 PIF1 POLD2 POLD2 RAD51D RAD51D PCNA PCNA PMS1 PMS1 MCM9 MCM9 GINS4 GINS4 PALB2 PALB2 DSCC1 DSCC1 ATRIP ATRIP ENSMFAP00000035495 ENSMFAP00000035495 RAD50 RAD50 SMARCAL1 SMARCAL1 DBF4 DBF4 RHNO1 RHNO1 MCM5 MCM5 GINS1 GINS1 POLE4 POLE4 RFC2 RFC2 MSH4 MSH4 CDC45 CDC45 POLD4 POLD4 MAD2L2 MAD2L2 MCMDC2 MCMDC2 PMS2 PMS2 MCM6 MCM6 DBF4B DBF4B RAD9A RAD9A EXD2 EXD2 MRE11 MRE11 POLE POLE ENSMFAP00000044257 ENSMFAP00000044257 ENSMFAP00000044831 ENSMFAP00000044831 FANCM FANCM CDC7 CDC7 MEIOB MEIOB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ENSMFAP00000000527Sld5 domain-containing protein. (151 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3127 aa)
MCMBPMinichromosome maintenance complex binding protein. (642 aa)
MSH5DNA_MISMATCH_REPAIR_2 domain-containing protein. (833 aa)
EME1Essential meiotic structure-specific endonuclease 1. (584 aa)
DNA2Uncharacterized protein. (948 aa)
DCLRE1ADNA cross-link repair 1A. (1039 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
POLD3DNA polymerase delta 3, accessory subunit. (466 aa)
POLA1DNA polymerase. (1478 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1622 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (277 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (898 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (323 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
MCM3DNA helicase; Belongs to the MCM family. (821 aa)
TM4SF19Uncharacterized protein. (311 aa)
ENSMFAP00000004513Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (934 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (341 aa)
RAD51CRAD51 paralog C. (370 aa)
BIVMBIVM-ERCC5 readthrough. (1638 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (533 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa)
ENSMFAP00000006564TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (269 aa)
ENSMFAP00000007027Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (506 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
ENSMFAP00000007488RPA_C domain-containing protein. (223 aa)
ATAD5ATPase family AAA domain containing 5. (1820 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
ENSMFAP00000007997DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (189 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
RAD52RAD52 homolog, DNA repair protein. (419 aa)
MLH1MutL homolog 1. (756 aa)
ENSMFAP00000009642Uncharacterized protein. (88 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (267 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
POLD1DNA polymerase. (1107 aa)
TDRD3Tudor domain containing 3. (744 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
POLIDNA polymerase iota. (659 aa)
RAD1RAD1 checkpoint DNA exonuclease. (280 aa)
RMI1RecQ mediated genome instability 1. (625 aa)
LIG1DNA ligase. (919 aa)
RPA2Replication protein A2. (270 aa)
EXO1Exonuclease 1. (846 aa)
PIEZO1Piezo-type mechanosensitive ion channel component. (2525 aa)
CLSPNClaspin. (1341 aa)
MCM2DNA helicase; Belongs to the MCM family. (900 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (379 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1059 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
RFC4Replication factor C subunit 4. (363 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
ENSMFAP00000014864Uncharacterized protein. (88 aa)
ENSMFAP00000015147Uncharacterized protein. (84 aa)
ENSMFAP00000015231Uncharacterized protein. (118 aa)
NBNNibrin. (754 aa)
RAD17RAD17 checkpoint clamp loader component. (681 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (877 aa)
RAD54LRAD54 like. (747 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
FSBPUncharacterized protein. (908 aa)
GINS3GINS complex subunit 3. (255 aa)
RMI2RecQ mediated genome instability 2. (147 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (307 aa)
RBBP8RB binding protein 8, endonuclease. (898 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1017 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
WDHD1WD repeat and HMG-box DNA binding protein 1. (1127 aa)
ENSMFAP00000020152Protein kinase domain-containing protein. (535 aa)
ENSMFAP00000020733Uncharacterized protein. (103 aa)
CHTF18Chromosome transmission fidelity factor 18. (1003 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1496 aa)
RECQL4RecQ like helicase 4. (1208 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
ENSMFAP00000022440Uncharacterized protein. (248 aa)
BLMBLM RecQ like helicase. (1416 aa)
RFWD3Ring finger and WD repeat domain 3. (774 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
POLKDNA polymerase kappa. (870 aa)
WRNWRN RecQ like helicase. (1428 aa)
RAD51BRAD51 paralog B. (425 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1250 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1124 aa)
MLH3MutL homolog 3. (1456 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1817 aa)
CDT1Chromatin licensing and DNA replication factor 1. (450 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1247 aa)
RFC5Replication factor C subunit 5. (343 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
BRCA1Uncharacterized protein. (1884 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (880 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (347 aa)
POLHDNA polymerase eta. (712 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
RFC3Replication factor C subunit 3/5. (356 aa)
ORC3Origin recognition complex subunit 3. (712 aa)
BRCA2BRCA2 DNA repair associated. (3418 aa)
RFC1Replication factor C subunit 1. (1148 aa)
RPA3Uncharacterized protein. (121 aa)
CHTF8Chromosome transmission fidelity factor 8. (121 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa)
POLD2Uncharacterized protein. (504 aa)
RAD51DRAD51 paralog D. (347 aa)
PCNAProliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] (261 aa)
PMS1PMS1 homolog 1, mismatch repair system component. (931 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
PALB2PALB2_WD40 domain-containing protein. (623 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (429 aa)
ATRIPATR-interacting protein; Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein (By similarity). (791 aa)
ENSMFAP00000035495Uncharacterized protein. (275 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (949 aa)
DBF4DBF4 zinc finger. (675 aa)
RHNO1Uncharacterized protein. (226 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
GINS1GINS complex subunit 1. (196 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
RFC2Replication factor C subunit 2. (352 aa)
MSH4MutS homolog 4. (935 aa)
CDC45Cell division cycle 45. (598 aa)
POLD4Uncharacterized protein. (107 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (828 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
DBF4BDBF4 zinc finger B. (535 aa)
RAD9ACell cycle checkpoint control protein RAD9A; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN [...] (390 aa)
EXD2Exonuclease 3'-5' domain containing 2. (620 aa)
MRE11Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] (707 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (370 aa)
ENSMFAP00000044257Uncharacterized protein. (83 aa)
ENSMFAP00000044831Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (577 aa)
FANCMFA complementation group M. (2050 aa)
CDC7Protein kinase domain-containing protein. (574 aa)
MEIOBMeiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...] (471 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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