STRINGSTRING
ORC1 ORC1 MCM3 MCM3 ORC5 ORC5 ORC2 ORC2 ORC6 ORC6 MCM2 MCM2 ORC4 ORC4 MCM4 MCM4 CDT1 CDT1 MCM7 MCM7 CDC6 CDC6 ORC3 ORC3 MCM5 MCM5 MCM6 MCM6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
MCM3DNA helicase; Belongs to the MCM family. (821 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
MCM2DNA helicase; Belongs to the MCM family. (900 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
CDT1Chromatin licensing and DNA replication factor 1. (450 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
ORC3Origin recognition complex subunit 3. (712 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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