STRINGSTRING
EXOSC9 EXOSC9 SYCE3 SYCE3 HNRNPU HNRNPU RRS1 RRS1 C14orf39 C14orf39 ENSMFAP00000000527 ENSMFAP00000000527 SYCP3 SYCP3 ENSMFAP00000000476 ENSMFAP00000000476 ZRANB3 ZRANB3 BRMS1 BRMS1 HDAC2 HDAC2 ORC2 ORC2 SMC2 SMC2 AGO3 AGO3 MCM4 MCM4 NCAPH2 NCAPH2 SFR1 SFR1 ENSMFAP00000020443 ENSMFAP00000020443 NUFIP1 NUFIP1 WDHD1 WDHD1 PRIM2 PRIM2 SRCAP SRCAP ING2 ING2 ENSMFAP00000019279 ENSMFAP00000019279 RAD21 RAD21 SYCE1 SYCE1 RUVBL2 RUVBL2 RAD21L1 RAD21L1 LRWD1 LRWD1 ATRX ATRX TIPIN TIPIN CFDP1 CFDP1 FAM9C FAM9C TFPT TFPT GINS3 GINS3 INCENP INCENP ORC4 ORC4 POLA2 POLA2 SYCE1L SYCE1L ADD3 ADD3 CHD1 CHD1 SPO11 SPO11 NIFK NIFK ENSMFAP00000016050 ENSMFAP00000016050 MCM10 MCM10 KIFAP3 KIFAP3 BRD4 BRD4 STAG2 STAG2 ENSMFAP00000015231 ENSMFAP00000015231 FAM9B FAM9B ENSMFAP00000015048 ENSMFAP00000015048 ENSMFAP00000014826 ENSMFAP00000014826 DMAP1 DMAP1 ENSMFAP00000014776 ENSMFAP00000014776 ENSMFAP00000014529 ENSMFAP00000014529 POLE3 POLE3 TIMELESS TIMELESS ACTL6A ACTL6A PINX1 PINX1 CHRAC1 CHRAC1 ENSMFAP00000012784 ENSMFAP00000012784 EME2 EME2 ENSMFAP00000012580 ENSMFAP00000012580 MCM2 MCM2 ENSMFAP00000012416 ENSMFAP00000012416 ENSMFAP00000012346 ENSMFAP00000012346 ENSMFAP00000012317 ENSMFAP00000012317 MCRS1 MCRS1 RPA2 RPA2 SUN2 SUN2 H3C1 H3C1 TREX2 TREX2 INO80C INO80C ENSMFAP00000011563 ENSMFAP00000011563 TONSL TONSL MEI4 MEI4 CCDC155 CCDC155 POLD1 POLD1 ENSMFAP00000010148 ENSMFAP00000010148 ORC6 ORC6 ENSMFAP00000010034 ENSMFAP00000010034 ENSMFAP00000010006 ENSMFAP00000010006 P3H4 P3H4 HIST1H3B HIST1H3B RPA1 RPA1 MLH1 MLH1 NCAPG NCAPG HORMAD1 HORMAD1 ANP32E ANP32E CHEK1 CHEK1 CDX2 CDX2 PBRM1 PBRM1 ENSMFAP00000022440 ENSMFAP00000022440 BLM BLM SYCE2 SYCE2 HSPA2 HSPA2 BAZ1A BAZ1A RSPH1 RSPH1 HMGA2 HMGA2 CCDC36 CCDC36 MLH3 MLH3 SLX4 SLX4 SPIDR SPIDR ING1 ING1 SYCP1 SYCP1 MCM7 MCM7 ARID4B ARID4B PSMC3IP PSMC3IP REC8 REC8 ENSMFAP00000025317 ENSMFAP00000025317 BRCA1 BRCA1 TET1 TET1 UBE2I UBE2I ING3 ING3 INO80 INO80 RAD51 RAD51 ENSMFAP00000026582 ENSMFAP00000026582 NCAPH NCAPH SIRT7 SIRT7 CPSF6 CPSF6 KMT2E KMT2E DMC1 DMC1 TRIM24 TRIM24 SYCP2L SYCP2L HORMAD2 HORMAD2 ORC3 ORC3 BRCA2 BRCA2 NEK2 NEK2 RPA3 RPA3 SMARCE1 SMARCE1 E2F1 E2F1 POLD2 POLD2 ACTR8 ACTR8 SMARCAD1 SMARCAD1 ENSMFAP00000031470 ENSMFAP00000031470 PCNA PCNA SYN1 SYN1 WAPL WAPL FKBP6 FKBP6 GINS4 GINS4 MACROH2A1 MACROH2A1 HDAC8 HDAC8 RUVBL1 RUVBL1 SMC3 SMC3 SMC4 SMC4 FAM9A FAM9A MMS22L MMS22L SINHCAF SINHCAF SMC1A SMC1A TEX12 TEX12 ZMIZ2 ZMIZ2 SMC1B SMC1B SMARCAL1 SMARCAL1 CCNB1IP1 CCNB1IP1 INO80E INO80E REPIN1 REPIN1 SAP30 SAP30 BRMS1L BRMS1L MCM5 MCM5 GINS1 GINS1 POLE4 POLE4 SMCHD1 SMCHD1 MSH4 MSH4 CDC45 CDC45 POLD4 POLD4 PLK1 PLK1 MCM6 MCM6 DHX9 DHX9 RAD9A RAD9A RNF212B RNF212B EP400 EP400 ETAA1 ETAA1 LRPPRC LRPPRC SETX SETX SHOC1 SHOC1 NOL6 NOL6 RNF212 RNF212 NFRKB NFRKB TEX11 TEX11 RCC1 RCC1 SPEGNB SPEGNB BRD8 BRD8 ENSMFAP00000043974 ENSMFAP00000043974 POLE POLE RGS12 RGS12 ENSMFAP00000044257 ENSMFAP00000044257 LRIF1 LRIF1 SETD5 SETD5 SAP30L SAP30L TRRAP TRRAP SYCP2 SYCP2 HDAC1 HDAC1 KAT5 KAT5 SIN3B SIN3B MUS81 MUS81 ENSMFAP00000007997 ENSMFAP00000007997 HUS1 HUS1 SMARCB1 SMARCB1 ENSMFAP00000007806 ENSMFAP00000007806 ENSMFAP00000007488 ENSMFAP00000007488 PHF12 PHF12 ENSMFAP00000007027 ENSMFAP00000007027 UCHL5 UCHL5 NCAPG2 NCAPG2 SIN3A SIN3A TTN TTN ENSMFAP00000006564 ENSMFAP00000006564 SAP130 SAP130 RAD9B RAD9B MACROH2A2 MACROH2A2 ORC5 ORC5 POLE2 POLE2 GINS2 GINS2 SLX1A SLX1A OGT OGT ENSMFAP00000004513 ENSMFAP00000004513 MCM3 MCM3 ACTR5 ACTR5 C17orf64 C17orf64 HUS1B HUS1B INO80D INO80D ENSMFAP00000003451 ENSMFAP00000003451 TOPBP1 TOPBP1 POLA1 POLA1 POLD3 POLD3 ACTR6 ACTR6 ORC1 ORC1 STAG3 STAG3 ZNHIT1 ZNHIT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EXOSC9Exosome component 9. (456 aa)
SYCE3Synaptonemal complex central element protein 3. (88 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
RRS1Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa)
C14orf39Chromosome 14 open reading frame 39. (613 aa)
ENSMFAP00000000527Sld5 domain-containing protein. (151 aa)
SYCP3Synaptonemal complex protein 3; Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2. (236 aa)
ENSMFAP00000000476DUF1785 domain-containing protein. (200 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1124 aa)
BRMS1Uncharacterized protein. (262 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
SMC2Structural maintenance of chromosomes protein. (1197 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
NCAPH2Non-SMC condensin II complex subunit H2. (605 aa)
SFR1SWI5 dependent homologous recombination repair protein 1. (245 aa)
ENSMFAP00000020443Rad21_Rec8 domain-containing protein. (521 aa)
NUFIP1Nuclear FMR1 interacting protein 1. (495 aa)
WDHD1WD repeat and HMG-box DNA binding protein 1. (1127 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
SRCAPUncharacterized protein. (3229 aa)
ING2Inhibitor of growth protein. (280 aa)
ENSMFAP00000019279Uncharacterized protein. (418 aa)
RAD21RAD21 cohesin complex component. (631 aa)
SYCE1Synaptonemal complex central element protein 1; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. (332 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (473 aa)
RAD21L1RAD21 cohesin complex component like 1. (556 aa)
LRWD1Leucine rich repeats and WD repeat domain containing 1. (647 aa)
ATRXATRX chromatin remodeler. (2490 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (307 aa)
CFDP1Craniofacial development protein 1; May play a role during embryogenesis. (299 aa)
FAM9CFamily with sequence similarity 9 member C. (166 aa)
TFPTTCF3 fusion partner. (253 aa)
GINS3GINS complex subunit 3. (255 aa)
INCENPInner centromere protein. (897 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
SYCE1LSynaptonemal complex central element protein 1 like. (242 aa)
ADD3Adducin 3. (706 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1712 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (396 aa)
NIFKNucleolar protein interacting with the FHA domain of MKI67. (293 aa)
ENSMFAP00000016050Uncharacterized protein. (202 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (877 aa)
KIFAP3Kinesin associated protein 3. (803 aa)
BRD4Bromodomain containing 4. (1359 aa)
STAG2Stromal antigen 2. (1268 aa)
ENSMFAP00000015231Uncharacterized protein. (118 aa)
FAM9BFamily with sequence similarity 9 member B. (226 aa)
ENSMFAP00000015048annotation not available (136 aa)
ENSMFAP00000014826annotation not available (136 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (612 aa)
ENSMFAP00000014776annotation not available (136 aa)
ENSMFAP00000014529Uncharacterized protein. (106 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
ACTL6AActin-like protein 6A; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remo [...] (429 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (328 aa)
CHRAC1Chromatin accessibility complex subunit 1. (131 aa)
ENSMFAP00000012784annotation not available (136 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (379 aa)
ENSMFAP00000012580DUF4502 domain-containing protein. (62 aa)
MCM2DNA helicase; Belongs to the MCM family. (900 aa)
ENSMFAP00000012416annotation not available (136 aa)
ENSMFAP00000012346Uncharacterized protein. (130 aa)
ENSMFAP00000012317Uncharacterized protein. (59 aa)
MCRS1Microspherule protein 1. (475 aa)
RPA2Replication protein A2. (270 aa)
SUN2Sad1 and UNC84 domain containing 2. (741 aa)
H3C1H3 clustered histone 1. (136 aa)
TREX2Three prime repair exonuclease 2. (279 aa)
INO80CYL1_C domain-containing protein. (228 aa)
ENSMFAP00000011563annotation not available (136 aa)
TONSLTonsoku like, DNA repair protein. (1375 aa)
MEI4Meiotic double-stranded break formation protein 4. (389 aa)
CCDC155Coiled-coil domain containing 155. (562 aa)
POLD1DNA polymerase. (1107 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
ENSMFAP00000010034annotation not available (136 aa)
ENSMFAP00000010006annotation not available (136 aa)
P3H4Prolyl 3-hydroxylase family member 4 (non-enzymatic). (437 aa)
HIST1H3BHistone H3; Belongs to the histone H3 family. (136 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (267 aa)
MLH1MutL homolog 1. (756 aa)
NCAPGNon-SMC condensin I complex subunit G. (1044 aa)
HORMAD1HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...] (394 aa)
ANP32EUncharacterized protein. (249 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (488 aa)
CDX2Caudal type homeobox 2. (313 aa)
PBRM1Polybromo 1. (1725 aa)
ENSMFAP00000022440Uncharacterized protein. (248 aa)
BLMBLM RecQ like helicase. (1416 aa)
SYCE2Synaptonemal complex central element protein 2. (218 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (641 aa)
BAZ1ABromodomain adjacent to zinc finger domain 1A. (1556 aa)
RSPH1Radial spoke head component 1. (309 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
CCDC36Coiled-coil domain containing 36. (599 aa)
MLH3MutL homolog 3. (1456 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1817 aa)
SPIDRScaffold protein involved in DNA repair. (815 aa)
ING1Inhibitor of growth protein. (417 aa)
SYCP1Synaptonemal complex protein 1. (976 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
ARID4BAT-rich interaction domain 4B. (1314 aa)
PSMC3IPPSMC3 interacting protein. (217 aa)
REC8REC8 meiotic recombination protein. (549 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
BRCA1Uncharacterized protein. (1884 aa)
TET1Tet methylcytosine dioxygenase 1. (2132 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
ING3Inhibitor of growth protein. (418 aa)
INO80INO80 complex ATPase subunit. (1556 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
ENSMFAP00000026582HMG box domain-containing protein. (177 aa)
NCAPHCondensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (744 aa)
SIRT7Sirtuin 7. (400 aa)
CPSF6Cleavage and polyadenylation specific factor 6. (589 aa)
KMT2ELysine methyltransferase 2E. (1859 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
TRIM24Tripartite motif containing 24. (1050 aa)
SYCP2LSynaptonemal complex protein 2 like. (787 aa)
HORMAD2HORMA domain containing 2. (307 aa)
ORC3Origin recognition complex subunit 3. (712 aa)
BRCA2BRCA2 DNA repair associated. (3418 aa)
NEK2NIMA related kinase 2. (445 aa)
RPA3Uncharacterized protein. (121 aa)
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa)
E2F1E2F transcription factor 1. (437 aa)
POLD2Uncharacterized protein. (504 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
SMARCAD1Uncharacterized protein. (1026 aa)
ENSMFAP00000031470Uncharacterized protein. (138 aa)
PCNAProliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] (261 aa)
SYN1Synapsin I. (705 aa)
WAPLWAPL cohesin release factor. (1190 aa)
FKBP6Peptidylprolyl isomerase. (327 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (377 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (445 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
SMC4Structural maintenance of chromosomes protein. (1287 aa)
FAM9AFamily with sequence similarity 9 member A. (268 aa)
MMS22LMMS22 like, DNA repair protein. (1243 aa)
SINHCAFSIN3-HDAC complex associated factor. (221 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
TEX12Testis expressed 12. (123 aa)
ZMIZ2Zinc finger MIZ-type containing 2. (921 aa)
SMC1BStructural maintenance of chromosomes protein. (1234 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (949 aa)
CCNB1IP1Cyclin B1 interacting protein 1. (277 aa)
INO80EINO80 complex subunit E. (244 aa)
REPIN1Replication initiator 1. (843 aa)
SAP30Sin3A associated protein 30. (220 aa)
BRMS1LBRMS1 like transcriptional repressor. (323 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
GINS1GINS complex subunit 1. (196 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (2005 aa)
MSH4MutS homolog 4. (935 aa)
CDC45Cell division cycle 45. (598 aa)
POLD4Uncharacterized protein. (107 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
DHX9DExH-box helicase 9. (1275 aa)
RAD9ACell cycle checkpoint control protein RAD9A; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN [...] (390 aa)
RNF212BRing finger protein 212B. (300 aa)
EP400E1A binding protein p400. (3136 aa)
ETAA1ETAA1 activator of ATR kinase. (896 aa)
LRPPRCPPR_long domain-containing protein. (1461 aa)
SETXSenataxin. (2680 aa)
SHOC1Shortage in chiasmata 1. (1444 aa)
NOL6Nucleolar protein 6. (1146 aa)
RNF212Ring finger protein 212. (215 aa)
NFRKBNuclear factor related to kappaB binding protein. (1247 aa)
TEX11Testis expressed 11. (940 aa)
RCC1Uncharacterized protein. (461 aa)
SPEGNBSPEG neighbor. (238 aa)
BRD8Bromodomain containing 8. (1235 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (370 aa)
RGS12Regulator of G protein signaling 12. (1447 aa)
ENSMFAP00000044257Uncharacterized protein. (83 aa)
LRIF1Ligand dependent nuclear receptor interacting factor 1. (760 aa)
SETD5SET domain containing 5. (1461 aa)
SAP30LSAP30 like. (184 aa)
TRRAPTransformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3859 aa)
SYCP2Synaptonemal complex protein 2. (1530 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
SIN3BSIN3 transcription regulator family member B. (1159 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
ENSMFAP00000007997DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (189 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (376 aa)
ENSMFAP00000007806EP400_N domain-containing protein. (401 aa)
ENSMFAP00000007488RPA_C domain-containing protein. (223 aa)
PHF12PHD finger protein 12. (1004 aa)
ENSMFAP00000007027Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (506 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (368 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1143 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
TTNTitin. (32000 aa)
ENSMFAP00000006564TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (269 aa)
SAP130Sin3A associated protein 130. (1083 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (533 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (341 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
ENSMFAP00000004513Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa)
MCM3DNA helicase; Belongs to the MCM family. (821 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (607 aa)
C17orf64Chromosome 17 open reading frame 64. (236 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (277 aa)
INO80DINO80 complex subunit D. (1027 aa)
ENSMFAP00000003451Uncharacterized protein. (180 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1622 aa)
POLA1DNA polymerase. (1478 aa)
POLD3DNA polymerase delta 3, accessory subunit. (466 aa)
ACTR6Actin related protein 6; Belongs to the actin family. (396 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
STAG3Stromal antigen 3. (1226 aa)
ZNHIT1Zinc finger HIT-type containing 1. (154 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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