50 items (Macaca fascicularis) - STRING interaction network

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	EZH2	Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is m [...] (751 aa)
	LCOR	Ligand dependent nuclear receptor corepressor. (1556 aa)
	WIZ	WIZ zinc finger. (968 aa)
	ENSMFAP00000043974	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	SUZ12	SUZ12 polycomb repressive complex 2 subunit. (739 aa)
	CTBP2	C-terminal binding protein 2. (985 aa)
	ELOC	Elongin C; Belongs to the SKP1 family. (112 aa)
	HDGF	Heparin binding growth factor. (256 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (613 aa)
	ENSMFAP00000037661	Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (101 aa)
	MTF2	Metal response element binding transcription factor 2. (593 aa)
	CNOT2	CCR4-NOT transcription complex subunit 2. (548 aa)
	PER3	Period circadian regulator 3. (1180 aa)
	STK36	Serine/threonine kinase 36. (1315 aa)
	LEF1	Lymphoid enhancer binding factor 1. (414 aa)
	STAT1	Signal transducer and activator of transcription. (758 aa)
	PER2	Period circadian regulator 2. (1254 aa)
	EED	Embryonic ectoderm development. (466 aa)
	ENSMFAP00000025317	Hist_deacetyl domain-containing protein. (258 aa)
	HDAC6	Histone deacetylase 6. (1215 aa)
	PER1	Period circadian regulator 1. (1292 aa)
	SIX3	SIX homeobox 3. (308 aa)
	USP11	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (978 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
	NEK6	NIMA related kinase 6; Belongs to the protein kinase superfamily. (347 aa)
	FAM89B	Family with sequence similarity 89 member B. (154 aa)
	RORA	RAR related orphan receptor A. (555 aa)
	ENSMFAP00000020360	Ubiquitin-like domain-containing protein. (113 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1266 aa)
	RUNX3	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
	EHMT1	Euchromatic histone lysine methyltransferase 1. (1291 aa)
	LOC102127640	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (437 aa)
	ELOB	Elongin B. (162 aa)
	ENSMFAP00000012453	Hist_deacetyl domain-containing protein. (223 aa)
	ENSMFAP00000012353	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (435 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (673 aa)
	ENSMFAP00000010148	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	ZBTB7A	Zinc finger and BTB domain containing 7A. (584 aa)
	BCL6	BCL6 transcription repressor. (708 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (438 aa)
	PHF12	PHD finger protein 12. (1004 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	THAP7	THAP domain containing 7. (309 aa)
	PBX1	PBX homeobox 1. (465 aa)
	ETS1	ETS proto-oncogene 1, transcription factor. (485 aa)
	PHF1	PHD finger protein 1. (559 aa)
	ZNF644	Zinc finger protein 644. (1368 aa)

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	ENSMFAP00000010148	ENSMFAP00000008164	ENSMFAP00000010148	BCL6 transcription repressor.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.521
BCL6	ENSMFAP00000025317	ENSMFAP00000008164	ENSMFAP00000025317	BCL6 transcription repressor.	Hist_deacetyl domain-containing protein.	0.478
BCL6	ENSMFAP00000043974	ENSMFAP00000008164	ENSMFAP00000043974	BCL6 transcription repressor.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.521
BCL6	EZH2	ENSMFAP00000008164	ENSMFAP00000043388	BCL6 transcription repressor.	Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is m [...]	0.494
BCL6	HDAC1	ENSMFAP00000008164	ENSMFAP00000008745	BCL6 transcription repressor.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.521
BCL6	LEF1	ENSMFAP00000008164	ENSMFAP00000032622	BCL6 transcription repressor.	Lymphoid enhancer binding factor 1.	0.507
BCL6	STAT1	ENSMFAP00000008164	ENSMFAP00000032549	BCL6 transcription repressor.	Signal transducer and activator of transcription.	0.529
CNOT2	ZNF644	ENSMFAP00000036693	ENSMFAP00000001998	CCR4-NOT transcription complex subunit 2.	Zinc finger protein 644.	0.628
CTBP1	CTBP2	ENSMFAP00000007244	ENSMFAP00000039440	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	C-terminal binding protein 2.	0.974
CTBP1	EHMT1	ENSMFAP00000007244	ENSMFAP00000015121	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Euchromatic histone lysine methyltransferase 1.	0.451
CTBP1	EHMT2	ENSMFAP00000007244	ENSMFAP00000018428	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Euchromatic histone lysine methyltransferase 2.	0.506
CTBP1	ENSMFAP00000010148	ENSMFAP00000007244	ENSMFAP00000010148	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.737
CTBP1	ENSMFAP00000012353	ENSMFAP00000007244	ENSMFAP00000012353	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.759
CTBP1	ENSMFAP00000012453	ENSMFAP00000007244	ENSMFAP00000012453	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Hist_deacetyl domain-containing protein.	0.405
CTBP1	ENSMFAP00000025317	ENSMFAP00000007244	ENSMFAP00000025317	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Hist_deacetyl domain-containing protein.	0.941
CTBP1	ENSMFAP00000043974	ENSMFAP00000007244	ENSMFAP00000043974	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.737
CTBP1	HDAC1	ENSMFAP00000007244	ENSMFAP00000008745	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.945
CTBP1	HDAC3	ENSMFAP00000007244	ENSMFAP00000005789	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.405
CTBP1	LCOR	ENSMFAP00000007244	ENSMFAP00000044612	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Ligand dependent nuclear receptor corepressor.	0.826
CTBP1	LEF1	ENSMFAP00000007244	ENSMFAP00000032622	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Lymphoid enhancer binding factor 1.	0.950

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