STRINGSTRING
UBE3A UBE3A DMRTA1 DMRTA1 TAF4 TAF4 INHA INHA ENSMFAP00000005981 ENSMFAP00000005981 MMP19 MMP19 PCYT1B PCYT1B KIT KIT FOXL2 FOXL2 FANCG FANCG TNFAIP6 TNFAIP6 EREG EREG BCL2 BCL2 ZNF830 ZNF830 FSHR FSHR SCAPER SCAPER GPR149 GPR149 SPO11 SPO11 ENSMFAP00000016996 ENSMFAP00000016996 SRC SRC LHCGR LHCGR FOXC1 FOXC1 BAX BAX ATM ATM INHBB INHBB KDR KDR EIF2B2 EIF2B2 EIF2B4 EIF2B4 BCL2L1 BCL2L1 KITLG KITLG DMC1 DMC1 EIF2B5 EIF2B5 BMPR1B BMPR1B SMAD4 SMAD4 MMP2 MMP2 AMH AMH PTX3 PTX3 CGA CGA INHBA INHBA MSH4 MSH4 CEBPB CEBPB CTNNA1 CTNNA1 SOD1 SOD1 LFNG LFNG FSHB FSHB ENSMFAP00000042133 ENSMFAP00000042133 VGF VGF ESR1 ESR1 GAS2 GAS2 IMMP2L IMMP2L BMP15 BMP15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
DMRTA1DMRT like family A1. (559 aa)
TAF4TATA-box binding protein associated factor 4. (635 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
ENSMFAP00000005981Uncharacterized protein. (471 aa)
MMP19Matrix metallopeptidase 19. (508 aa)
PCYT1BPhosphate cytidylyltransferase 1, choline, beta. (359 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
FOXL2Forkhead box L2. (376 aa)
FANCGFA complementation group G. (622 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
EREGEpiregulin. (169 aa)
BCL2BCL2 apoptosis regulator. (242 aa)
ZNF830Zinc finger protein 830. (388 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1400 aa)
GPR149G protein-coupled receptor 149. (731 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (396 aa)
ENSMFAP00000016996HECT domain-containing protein. (736 aa)
SRCTyrosine-protein kinase. (542 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (703 aa)
FOXC1Forkhead box C1. (504 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
INHBBInhibin subunit beta B. (360 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
EIF2B2Uncharacterized protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (543 aa)
BCL2L1BCL2 like 1. (233 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (721 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
AMHAnti-Mullerian hormone. (562 aa)
PTX3Pentraxin 3. (381 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (150 aa)
INHBAInhibin subunit beta A. (426 aa)
MSH4MutS homolog 4. (935 aa)
CEBPBCCAAT/enhancer-binding protein. (314 aa)
CTNNA1Catenin alpha 1. (906 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (283 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs (By similarity). (129 aa)
ENSMFAP00000042133HECT domain-containing protein. (55 aa)
VGFVGF nerve growth factor inducible. (615 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
GAS2Growth arrest specific 2. (331 aa)
IMMP2LMitochondrial inner membrane protease subunit. (175 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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