STRINGSTRING
PIK3CD PIK3CD VIP VIP RPTOR RPTOR STAT3 STAT3 JCAD JCAD SIRT6 SIRT6 TNFSF12 TNFSF12 BMP6 BMP6 BMP4 BMP4 ITGA4 ITGA4 PLXNB3 PLXNB3 MDK MDK STAT5A STAT5A PRKCA PRKCA PROK1 PROK1 ZNF580 ZNF580 APLNR APLNR PDPK1 PDPK1 CCL26 CCL26 APELA APELA PDGFB PDGFB AKT1 AKT1 GDF2 GDF2 BMPR2 BMPR2 CYBA CYBA HIF1A HIF1A NRP1 NRP1 THBS4 THBS4 AKT3 AKT3 KDR KDR GHRL GHRL BMP2 BMP2 VEGFA VEGFA PGF PGF VEGFB VEGFB IGF2 IGF2 TEK TEK TGFBR1 TGFBR1 SP1 SP1 NR4A1 NR4A1 ARG1 ARG1 LRG1 LRG1 AGTR1 AGTR1 CCL24 CCL24 VASH2 VASH2 F3 F3 FGF7 FGF7 PROX1 PROX1 NRAS NRAS VEGFD VEGFD CCR3 CCR3 IL10 IL10 HTR2B HTR2B FGF10 FGF10 EGF EGF VEGFC VEGFC PPP1R16B PPP1R16B WNT5A WNT5A FGFR1 FGFR1 AGGF1 AGGF1 GATA2 GATA2 GHSR GHSR EGR3 EGR3 SEMA5A SEMA5A PRKD2 PRKD2 SIRT1 SIRT1 NF1 NF1 CXCL12 CXCL12 ACVRL1 ACVRL1 ITGB3 ITGB3 PRKD1 PRKD1 ECM1 ECM1 ADAM17 ADAM17 ARNT ARNT NRP2 NRP2 HMOX1 HMOX1 FLT4 FLT4 MYDGF MYDGF EMC10 EMC10 PLCG1 PLCG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
VIPVasoactive intestinal peptide. (170 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
JCADJunctional cadherin 5 associated. (1356 aa)
SIRT6Sirtuin 6. (355 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (250 aa)
BMP6Bone morphogenetic protein 6. (509 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
PLXNB3Plexin B3. (1992 aa)
MDKMidkine. (143 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PROK1Prokineticin 1. (105 aa)
ZNF580Zinc finger protein 580. (172 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (510 aa)
CCL26C-C motif chemokine. (94 aa)
APELAUncharacterized protein. (54 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GDF2Growth differentiation factor 2. (429 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
HIF1AUncharacterized protein. (831 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
THBS4Thrombospondin 4. (961 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
BMP2Bone morphogenetic protein 2. (544 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (409 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (200 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
IGF2Insulin like growth factor 2. (183 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
SP1Sp1 transcription factor. (786 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (670 aa)
ARG1Arginase. (322 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
VASH2Vasohibin 2. (355 aa)
F3Coagulation factor III, tissue factor. (296 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PROX1Prospero homeobox 1. (737 aa)
NRASUncharacterized protein. (189 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
CCR3C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. (376 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (465 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
AGGF1Uncharacterized protein. (710 aa)
GATA2GATA binding protein 2. (480 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
EGR3Early growth response 3. (387 aa)
SEMA5ASemaphorin 5A. (1074 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
SIRT1Sirtuin 1. (743 aa)
NF1Neurofibromin 1. (2849 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
ECM1Extracellular matrix protein 1. (540 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
HMOX1Uncharacterized protein. (288 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
MYDGFMyeloid derived growth factor. (190 aa)
EMC10ER membrane protein complex subunit 10. (335 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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