STRINGSTRING
SMAD4 SMAD4 NOTCH1 NOTCH1 HEY1 HEY1 EFNA1 EFNA1 TGFBR2 TGFBR2 ACVR1 ACVR1 HEYL HEYL SMAD6 SMAD6 TBX5 TBX5 BMP2 BMP2 DCHS1 DCHS1 GATA4 GATA4 BMPR2 BMPR2 HEY2 HEY2 SOX4 SOX4 SLIT3 SLIT3 OLFM1 OLFM1 CCN1 CCN1 BMPR1A BMPR1A TGFB2 TGFB2 MDM4 MDM4 ZFPM1 ZFPM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD4Mothers against decapentaplegic homolog. (552 aa)
NOTCH1Notch receptor 1. (2556 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
TBX5T-box transcription factor 5. (518 aa)
BMP2Bone morphogenetic protein 2. (544 aa)
DCHS1Dachsous cadherin-related 1. (3295 aa)
GATA4GATA binding protein 4. (425 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
SOX4Transcription factor SOX. (474 aa)
SLIT3Slit guidance ligand 3. (1480 aa)
OLFM1Olfactomedin 1. (467 aa)
CCN1Cellular communication network factor 1. (381 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (478 aa)
ZFPM1Zinc finger protein, FOG family member 1. (878 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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