STRINGSTRING
IKZF1 IKZF1 CBX3 CBX3 EZH2 EZH2 NCAPD3 NCAPD3 CENPA CENPA ENSMFAP00000039110 ENSMFAP00000039110 ENSMFAP00000038818 ENSMFAP00000038818 KDM4C KDM4C CBX5 CBX5 MACROH2A1 MACROH2A1 KDM4B KDM4B CBX1 CBX1 ESCO2 ESCO2 HELLS HELLS ENSMFAP00000025280 ENSMFAP00000025280 SMARCA5 SMARCA5 BAZ1A BAZ1A UHRF2 UHRF2 CENPB CENPB LRWD1 LRWD1 ATRX ATRX INCENP INCENP BAZ1B BAZ1B CHRAC1 CHRAC1 DNMT1 DNMT1 CENPC CENPC ZNF618 ZNF618 SNAI1 SNAI1 KMT5C KMT5C ENSMFAP00000004478 ENSMFAP00000004478 SIRT6 SIRT6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IKZF1IKAROS family zinc finger 1. (519 aa)
CBX3Uncharacterized protein. (183 aa)
EZH2Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is m [...] (751 aa)
NCAPD3Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1498 aa)
CENPACentromere protein A. (138 aa)
ENSMFAP00000039110TTD domain-containing protein. (163 aa)
ENSMFAP00000038818Uncharacterized protein. (1038 aa)
KDM4CLysine demethylase 4C. (1056 aa)
CBX5Chromobox 5. (191 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
KDM4BLysine demethylase 4B. (1130 aa)
CBX1Uncharacterized protein. (269 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (600 aa)
HELLSHelicase, lymphoid specific. (882 aa)
ENSMFAP00000025280Uncharacterized protein. (179 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
BAZ1ABromodomain adjacent to zinc finger domain 1A. (1556 aa)
UHRF2Ubiquitin like with PHD and ring finger domains 2. (802 aa)
CENPBCentromere protein B. (603 aa)
LRWD1Leucine rich repeats and WD repeat domain containing 1. (647 aa)
ATRXATRX chromatin remodeler. (2490 aa)
INCENPInner centromere protein. (897 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1486 aa)
CHRAC1Chromatin accessibility complex subunit 1. (131 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1632 aa)
CENPCCentromere protein C. (945 aa)
ZNF618Zinc finger protein 618. (1012 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
KMT5CLysine methyltransferase 5C. (461 aa)
ENSMFAP00000004478Uncharacterized protein. (187 aa)
SIRT6Sirtuin 6. (355 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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