STRINGSTRING
RFC4 RFC4 TERF1 TERF1 BRPF3 BRPF3 CDC7 CDC7 NRM NRM E2F7 E2F7 WIZ WIZ STOML2 STOML2 NFRKB NFRKB TTF1 TTF1 HCRT HCRT DBF4B DBF4B DHX9 DHX9 NUCKS1 NUCKS1 KCTD13 KCTD13 MCM6 MCM6 E2F8 E2F8 MAP2K4 MAP2K4 GTPBP4 GTPBP4 METTL4 METTL4 RBBP6 RBBP6 TP53 TP53 RFC2 RFC2 GINS1 GINS1 MCM5 MCM5 EGFR EGFR AICDA AICDA INO80E INO80E CCNA2 CCNA2 CIZ1 CIZ1 DBF4 DBF4 SMARCAL1 SMARCAL1 OBI1 OBI1 TSPYL2 TSPYL2 PPP2CA PPP2CA EGF EGF DSCC1 DSCC1 GLI2 GLI2 SMC3 SMC3 RUVBL1 RUVBL1 GINS4 GINS4 POLG2 POLG2 CCDC88A CCDC88A WAPL WAPL PCNA PCNA ESCO1 ESCO1 ACTR8 ACTR8 FBXO5 FBXO5 CHTF8 CHTF8 BRCA2 BRCA2 ORC3 ORC3 RFC3 RFC3 ID3 ID3 BCAR3 BCAR3 ENSMFAP00000027412 ENSMFAP00000027412 CDK2 CDK2 ESCO2 ESCO2 INO80 INO80 CDC6 CDC6 RFC5 RFC5 ZMPSTE24 ZMPSTE24 MCM7 MCM7 CDT1 CDT1 NUGGC NUGGC SMARCA5 SMARCA5 PDS5A PDS5A BAZ1A BAZ1A BLM BLM LIG3 LIG3 LPIN1 LPIN1 FBXO18 FBXO18 ENSMFAP00000021666 ENSMFAP00000021666 MCM4 MCM4 ING5 ING5 CHTF18 CHTF18 ENSMFAP00000020427 ENSMFAP00000020427 ENSMFAP00000020152 ENSMFAP00000020152 SSBP1 SSBP1 GLI1 GLI1 ENSMFAP00000019379 ENSMFAP00000019379 RUVBL2 RUVBL2 EHMT2 EHMT2 ATRX ATRX DACH1 DACH1 GDF2 GDF2 NPM2 NPM2 TIPIN TIPIN GMNC GMNC TFPT TFPT GMNN GMNN GINS3 GINS3 FAF1 FAF1 TICRR TICRR ENSMFAP00000014864 ENSMFAP00000014864 POLE3 POLE3 TIMELESS TIMELESS ACTL6A ACTL6A DONSON DONSON CHRAC1 CHRAC1 ENSMFAP00000013449 ENSMFAP00000013449 JADE2 JADE2 ENSMFAP00000012946 ENSMFAP00000012946 ZNF830 ZNF830 MCM2 MCM2 MCRS1 MCRS1 ZBTB38 ZBTB38 INO80C INO80C WBP1 WBP1 ENSMFAP00000011440 ENSMFAP00000011440 MCIDAS MCIDAS MAS1 MAS1 EREG EREG JADE3 JADE3 ATR ATR CTC1 CTC1 WRNIP1 WRNIP1 BCL6 BCL6 ATAD5 ATAD5 UCHL5 UCHL5 ENSMFAP00000006564 ENSMFAP00000006564 ENSMFAP00000006056 ENSMFAP00000006056 ORC5 ORC5 GINS2 GINS2 ENSMFAP00000004513 ENSMFAP00000004513 ACTR5 ACTR5 INO80D INO80D ENPP7 ENPP7 ENSMFAP00000003451 ENSMFAP00000003451 PPP2R1A PPP2R1A CDAN1 CDAN1 KAT7 KAT7 MEAF6 MEAF6 ATF1 ATF1 DNA2 DNA2 JADE1 JADE1 ANKRD17 ANKRD17 ENSMFAP00000000527 ENSMFAP00000000527 ZRANB3 ZRANB3 S100A11 S100A11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RFC4Replication factor C subunit 4. (363 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (438 aa)
BRPF3Bromodomain and PHD finger containing 3. (1205 aa)
CDC7Protein kinase domain-containing protein. (574 aa)
NRMNurim. (262 aa)
E2F7E2F transcription factor 7. (910 aa)
WIZWIZ zinc finger. (968 aa)
STOML2Stomatin like 2. (361 aa)
NFRKBNuclear factor related to kappaB binding protein. (1247 aa)
TTF1Transcription termination factor 1. (916 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)
DBF4BDBF4 zinc finger B. (535 aa)
DHX9DExH-box helicase 9. (1275 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa)
KCTD13Potassium channel tetramerization domain containing 13. (329 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
E2F8E2F transcription factor 8. (867 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
GTPBP4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
METTL4Methyltransferase like 4; Belongs to the MT-A70-like family. (439 aa)
RBBP6RB binding protein 6, ubiquitin ligase. (1791 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa)
RFC2Replication factor C subunit 2. (352 aa)
GINS1GINS complex subunit 1. (196 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
AICDAActivation induced cytidine deaminase. (199 aa)
INO80EINO80 complex subunit E. (244 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
CIZ1CDKN1A interacting zinc finger protein 1. (933 aa)
DBF4DBF4 zinc finger. (675 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (949 aa)
OBI1ORC ubiquitin ligase 1. (726 aa)
TSPYL2Testis-specific Y-encoded-like protein 2; Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression (By similarity). (695 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (429 aa)
GLI2GLI family zinc finger 2. (1561 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (445 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (431 aa)
CCDC88ACoiled-coil domain containing 88A. (1870 aa)
WAPLWAPL cohesin release factor. (1190 aa)
PCNAProliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] (261 aa)
ESCO1Establishment of sister chromatid cohesion N-acetyltransferase 1. (840 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
FBXO5F-box protein 5. (448 aa)
CHTF8Chromosome transmission fidelity factor 8. (121 aa)
BRCA2BRCA2 DNA repair associated. (3418 aa)
ORC3Origin recognition complex subunit 3. (712 aa)
RFC3Replication factor C subunit 3/5. (356 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
BCAR3Breast cancer anti-estrogen resistance protein 3 homolog; Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (By similarity). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and [...] (823 aa)
ENSMFAP00000027412Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (308 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (600 aa)
INO80INO80 complex ATPase subunit. (1556 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
RFC5Replication factor C subunit 5. (343 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (490 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
CDT1Chromatin licensing and DNA replication factor 1. (450 aa)
NUGGCNuclear GTPase, germinal center associated. (796 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
PDS5APDS5 cohesin associated factor A. (1337 aa)
BAZ1ABromodomain adjacent to zinc finger domain 1A. (1556 aa)
BLMBLM RecQ like helicase. (1416 aa)
LIG3DNA ligase. (1009 aa)
LPIN1Lipin 1. (975 aa)
FBXO18Uncharacterized protein. (344 aa)
ENSMFAP00000021666EF-hand domain-containing protein; Belongs to the S-100 family. (107 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
ING5Inhibitor of growth family member 5. (252 aa)
CHTF18Chromosome transmission fidelity factor 18. (1003 aa)
ENSMFAP00000020427Uncharacterized protein. (1151 aa)
ENSMFAP00000020152Protein kinase domain-containing protein. (535 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
GLI1GLI family zinc finger 1. (1106 aa)
ENSMFAP00000019379Uncharacterized protein. (448 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (473 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1266 aa)
ATRXATRX chromatin remodeler. (2490 aa)
DACH1Dachshund family transcription factor 1. (505 aa)
GDF2Growth differentiation factor 2. (429 aa)
NPM2Nucleophosmin/nucleoplasmin 2. (214 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (307 aa)
GMNCGeminin coiled-coil domain containing. (354 aa)
TFPTTCF3 fusion partner. (253 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
GINS3GINS complex subunit 3. (255 aa)
FAF1Fas associated factor 1. (650 aa)
TICRRTOPBP1 interacting checkpoint and replication regulator. (1906 aa)
ENSMFAP00000014864Uncharacterized protein. (88 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
ACTL6AActin-like protein 6A; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remo [...] (429 aa)
DONSONUncharacterized protein. (564 aa)
CHRAC1Chromatin accessibility complex subunit 1. (131 aa)
ENSMFAP00000013449Protein S100; Belongs to the S-100 family. (105 aa)
JADE2Jade family PHD finger 2. (834 aa)
ENSMFAP00000012946Protein S100; Belongs to the S-100 family. (104 aa)
ZNF830Zinc finger protein 830. (388 aa)
MCM2DNA helicase; Belongs to the MCM family. (900 aa)
MCRS1Microspherule protein 1. (475 aa)
ZBTB38Zinc finger and BTB domain containing 38. (1195 aa)
INO80CYL1_C domain-containing protein. (228 aa)
WBP1WW domain binding protein 1. (305 aa)
ENSMFAP00000011440Protein S100; Belongs to the S-100 family. (105 aa)
MCIDASMulticiliate differentiation and DNA synthesis associated cell cycle protein. (385 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
EREGEpiregulin. (169 aa)
JADE3Jade family PHD finger 3. (823 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
CTC1CST telomere replication complex component 1. (1217 aa)
WRNIP1WRN helicase interacting protein 1. (665 aa)
BCL6BCL6 transcription repressor. (708 aa)
ATAD5ATPase family AAA domain containing 5. (1820 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (368 aa)
ENSMFAP00000006564TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (269 aa)
ENSMFAP00000006056Uncharacterized protein. (480 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
ENSMFAP00000004513Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (607 aa)
INO80DINO80 complex subunit D. (1027 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (458 aa)
ENSMFAP00000003451Uncharacterized protein. (180 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A regulatory subunit A. (589 aa)
CDAN1Codanin 1. (1228 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
MEAF6MYST/Esa1 associated factor 6. (201 aa)
ATF1Activating transcription factor 1. (270 aa)
DNA2Uncharacterized protein. (948 aa)
JADE1Jade family PHD finger 1. (843 aa)
ANKRD17Ankyrin repeat domain 17. (2585 aa)
ENSMFAP00000000527Sld5 domain-containing protein. (151 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1124 aa)
S100A11Protein S100; Belongs to the S-100 family. (105 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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