STRINGSTRING
EIF4G1 EIF4G1 ENSMFAP00000035641 ENSMFAP00000035641 LOC102143207 LOC102143207 CSDE1 CSDE1 DHX29 DHX29 ENSMFAP00000034212 ENSMFAP00000034212 ENSMFAP00000033189 ENSMFAP00000033189 EIF4B EIF4B IMPACT IMPACT PPP1R15A PPP1R15A UHMK1 UHMK1 EIF2B5 EIF2B5 HSPB1 HSPB1 ENSMFAP00000027163 ENSMFAP00000027163 MTIF2 MTIF2 NCK1 NCK1 ENSMFAP00000025493 ENSMFAP00000025493 ENSMFAP00000025396 ENSMFAP00000025396 C8orf88 C8orf88 EIF2B2 EIF2B2 ENSMFAP00000023932 ENSMFAP00000023932 RPS6KB1 RPS6KB1 PAIP1 PAIP1 METTL3 METTL3 ENSMFAP00000022878 ENSMFAP00000022878 ENSMFAP00000022314 ENSMFAP00000022314 EIF4G3 EIF4G3 EIF2AK4 EIF2AK4 NCK2 NCK2 EIF5 EIF5 TPR TPR PAIP2 PAIP2 EIF4H EIF4H POLR2D POLR2D EIF2AK3 EIF2AK3 LARP1 LARP1 RPS6KB2 RPS6KB2 ENSMFAP00000016028 ENSMFAP00000016028 BOLL BOLL NCBP1 NCBP1 EIF2AK2 EIF2AK2 AGO2 AGO2 PAIP2B PAIP2B YTHDF2 YTHDF2 BZW1 BZW1 KLHL25 KLHL25 DDX3X DDX3X EIF3H EIF3H NPM1 NPM1 FMR1 FMR1 RPL13A RPL13A ENSMFAP00000008653 ENSMFAP00000008653 KHDRBS1 KHDRBS1 EIF4EBP2 EIF4EBP2 HABP4 HABP4 RBM4B RBM4B POLR2G POLR2G ENSMFAP00000007021 ENSMFAP00000007021 YTHDF1 YTHDF1 ENSMFAP00000006551 ENSMFAP00000006551 ENSMFAP00000006058 ENSMFAP00000006058 DAZL DAZL PML PML ENSMFAP00000005021 ENSMFAP00000005021 PPP1CA PPP1CA ALKBH1 ALKBH1 TNF TNF ENSMFAP00000002634 ENSMFAP00000002634 ENSMFAP00000001669 ENSMFAP00000001669 ENSMFAP00000001598 ENSMFAP00000001598 ENSMFAP00000001570 ENSMFAP00000001570 MIF4GD MIF4GD EIF4G2 EIF4G2 TMED2 TMED2 ENSMFAP00000000767 ENSMFAP00000000767 ATF4 ATF4 EIF4EBP1 EIF4EBP1 ENSMFAP00000045074 ENSMFAP00000045074 EIF2AK1 EIF2AK1 EIF1 EIF1 EIF3K EIF3K PPP1R15B PPP1R15B BZW2 BZW2 MTOR MTOR LOC102123956 LOC102123956 BANK1 BANK1 EIF3B EIF3B ENSMFAP00000039768 ENSMFAP00000039768 ENSMFAP00000039100 ENSMFAP00000039100 ENSMFAP00000037361 ENSMFAP00000037361 CTIF CTIF EIF2S1 EIF2S1 ENSMFAP00000036680 ENSMFAP00000036680 ENSMFAP00000036291 ENSMFAP00000036291 DNAJC3 DNAJC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1605 aa)
ENSMFAP00000035641RRM domain-containing protein. (539 aa)
LOC102143207Uncharacterized protein. (206 aa)
CSDE1Cold shock domain containing E1. (844 aa)
DHX29ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1367 aa)
ENSMFAP00000034212RWD domain-containing protein. (293 aa)
ENSMFAP00000033189Uncharacterized protein. (192 aa)
EIF4BRRM domain-containing protein. (612 aa)
IMPACTRWD domain-containing protein. (320 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (675 aa)
UHMK1U2AF homology motif kinase 1. (419 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (721 aa)
HSPB1SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
ENSMFAP00000027163RRM domain-containing protein. (594 aa)
MTIF2Mitochondrial translational initiation factor 2. (727 aa)
NCK1Cytoplasmic protein. (377 aa)
ENSMFAP00000025493Uncharacterized protein. (274 aa)
ENSMFAP00000025396Uncharacterized protein. (274 aa)
C8orf88Chromosome 8 open reading frame 88. (117 aa)
EIF2B2Uncharacterized protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
ENSMFAP00000023932Uncharacterized protein. (256 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PAIP1Poly(A) binding protein interacting protein 1. (480 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
ENSMFAP00000022878Uncharacterized protein. (180 aa)
ENSMFAP00000022314Uncharacterized protein. (200 aa)
EIF4G3Eukaryotic translation initiation factor 4 gamma 3. (1740 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1248 aa)
NCK2Cytoplasmic protein. (382 aa)
EIF5Eukaryotic translation initiation factor 5. (431 aa)
TPRTranslocated promoter region, nuclear basket protein. (2439 aa)
PAIP2Poly(A) binding protein interacting protein 2. (126 aa)
EIF4HRRM domain-containing protein. (248 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
LARP1La ribonucleoprotein domain family member 1. (1021 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
ENSMFAP00000016028Uncharacterized protein. (232 aa)
BOLLProtein boule-like; Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity). (320 aa)
NCBP1Nuclear cap binding protein subunit 1. (790 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (554 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (881 aa)
PAIP2BPoly(A) binding protein interacting protein 2B. (123 aa)
YTHDF2YTH domain-containing family protein 2; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in mRNA degradation. Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence o [...] (593 aa)
BZW1Basic leucine zipper and W2 domains 1. (451 aa)
KLHL25Kelch like family member 25. (589 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
EIF3HEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (366 aa)
NPM1Uncharacterized protein. (305 aa)
FMR1Fragile X mental retardation 1. (632 aa)
RPL13A60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppres [...] (203 aa)
ENSMFAP00000008653Uncharacterized protein. (311 aa)
KHDRBS1KH domain-containing protein. (443 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (120 aa)
HABP4Hyaluronan binding protein 4. (413 aa)
RBM4BRNA-binding protein 4; RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation [...] (359 aa)
POLR2GS1 domain-containing protein. (234 aa)
ENSMFAP00000007021Uncharacterized protein. (195 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (559 aa)
ENSMFAP00000006551Uncharacterized protein. (229 aa)
ENSMFAP00000006058Uncharacterized protein. (305 aa)
DAZLDeleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity). (315 aa)
PMLPromyelocytic leukemia. (882 aa)
ENSMFAP00000005021Uncharacterized protein. (109 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
ENSMFAP00000002634Uncharacterized protein. (284 aa)
ENSMFAP00000001669Uncharacterized protein. (268 aa)
ENSMFAP00000001598SUI1 domain-containing protein. (115 aa)
ENSMFAP00000001570GOLD domain-containing protein. (188 aa)
MIF4GDMIF4G domain containing. (262 aa)
EIF4G2Eukaryotic translation initiation factor 4 gamma 2. (925 aa)
TMED2GOLD domain-containing protein. (208 aa)
ENSMFAP00000000767Uncharacterized protein. (208 aa)
ATF4Activating transcription factor 4. (351 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
ENSMFAP00000045074Uncharacterized protein. (128 aa)
EIF2AK1Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser- 51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] (631 aa)
EIF1Eukaryotic translation initiation factor 1. (113 aa)
EIF3KEukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (218 aa)
PPP1R15BProtein phosphatase 1 regulatory subunit 15B. (710 aa)
BZW2Basic leucine zipper and W2 domain-containing protein 2; May be involved in neuronal differentiation. (519 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
LOC102123956ANK_REP_REGION domain-containing protein. (2626 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (786 aa)
EIF3BEukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; Belongs to the eIF-3 subunit B family. (775 aa)
ENSMFAP00000039768SUI1 domain-containing protein. (118 aa)
ENSMFAP00000039100Uncharacterized protein. (329 aa)
ENSMFAP00000037361Uncharacterized protein. (111 aa)
CTIFCap binding complex dependent translation initiation factor. (600 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
ENSMFAP00000036680RWD domain-containing protein. (136 aa)
ENSMFAP00000036291RRM domain-containing protein. (241 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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