STRINGSTRING
SPRN SPRN SIX2 SIX2 PPP3CA PPP3CA TNPO1 TNPO1 SNUPN SNUPN ENSMFAP00000034417 ENSMFAP00000034417 E2F3 E2F3 RAN RAN ENSMFAP00000033991 ENSMFAP00000033991 ADAR ADAR GPN3 GPN3 ENSMFAP00000032784 ENSMFAP00000032784 NUP62 NUP62 SEC13 SEC13 NUP88 NUP88 GPN2 GPN2 SHH SHH FGF9 FGF9 ENSMFAP00000031387 ENSMFAP00000031387 RPAIN RPAIN NUP85 NUP85 LMNA LMNA SHISA4 SHISA4 PIK3R1 PIK3R1 SMO SMO CRY2 CRY2 NUP98 NUP98 NUP133 NUP133 ENSMFAP00000025017 ENSMFAP00000025017 ING1 ING1 APPL2 APPL2 RANGRF RANGRF ABRA ABRA KPNA3 KPNA3 IPO9 IPO9 NUP50 NUP50 IPO11 IPO11 HIKESHI HIKESHI TSC2 TSC2 SYK SYK PTTG1IP PTTG1IP TPR TPR TNPO3 TNPO3 NUP107 NUP107 AKT1 AKT1 KPNA7 KPNA7 POLA2 POLA2 PPP3R1 PPP3R1 GLI3 GLI3 NUP54 NUP54 CBLB CBLB STK4 STK4 RANBP2 RANBP2 KPNB1 KPNB1 FAM53B FAM53B ENSMFAP00000012963 ENSMFAP00000012963 AKIRIN2 AKIRIN2 PRICKLE1 PRICKLE1 NXT1 NXT1 NFKBIA NFKBIA IPO8 IPO8 LOC102126330 LOC102126330 NXT2 NXT2 APPL1 APPL1 NUP35 NUP35 RANBP6 RANBP6 IPO4 IPO4 STK3 STK3 SPG11 SPG11 BCL3 BCL3 ELAVL1 ELAVL1 POM121C POM121C NUTF2 NUTF2 IPO7 IPO7 IPO5 IPO5 ATF2 ATF2 PML PML HEATR3 HEATR3 FAM53C FAM53C CDKN1A CDKN1A TNPO2 TNPO2 STAT3 STAT3 LRRK2 LRRK2 NUP214 NUP214 KPNA5 KPNA5 KPNA2 KPNA2 NUP153 NUP153 NUP62CL NUP62CL ENSMFAP00000039407 ENSMFAP00000039407 MED1 MED1 KPNA1 KPNA1 NF1 NF1 KPNA4 KPNA4 ENSMFAP00000042185 ENSMFAP00000042185 NUP155 NUP155 TRAF3IP2 TRAF3IP2 GCKR GCKR KPNA6 KPNA6 NOTCH1 NOTCH1 EIF4ENIF1 EIF4ENIF1 MMP12 MMP12 TP53 TP53 ENSMFAP00000038879 ENSMFAP00000038879 FAM53A FAM53A LOC102119659 LOC102119659 RANBP17 RANBP17 TMCO6 TMCO6 LOC107127914 LOC107127914
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPRNShadow of prion protein. (151 aa)
SIX2SIX homeobox 2. (303 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
TNPO1Transportin 1. (898 aa)
SNUPNSnurportin 1. (293 aa)
ENSMFAP00000034417Uncharacterized protein. (422 aa)
E2F3E2F transcription factor 3. (335 aa)
RANGTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (233 aa)
ENSMFAP00000033991Uncharacterized protein. (418 aa)
ADARAdenosine deaminase RNA specific. (1228 aa)
GPN3GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (323 aa)
ENSMFAP00000032784Uncharacterized protein. (353 aa)
NUP62Nucleoporin 62. (338 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa)
NUP88Nucleoporin 88. (741 aa)
GPN2GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (310 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSMFAP00000031387NTF2 domain-containing protein. (120 aa)
RPAINRPA interacting protein. (226 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (656 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (663 aa)
SHISA4Shisa family member 4. (197 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
CRY2Cryptochrome circadian regulator 2. (614 aa)
NUP98Nucleoporin 98. (1610 aa)
NUP133Nucleoporin 133. (1156 aa)
ENSMFAP00000025017Uncharacterized protein. (188 aa)
ING1Inhibitor of growth protein. (417 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (666 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
ABRAActin binding Rho activating protein. (381 aa)
KPNA3Importin subunit alpha; Functions in nuclear protein import. (521 aa)
IPO9Importin 9. (1041 aa)
NUP50Testis cDNA clone: QtsA-12809, similar to human nucleoporin 50kDa (NUP50), transcript variant 2. (468 aa)
IPO11Importin 11. (1015 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (197 aa)
TSC2TSC complex subunit 2. (1807 aa)
SYKTyrosine-protein kinase. (635 aa)
PTTG1IPPTTG1 interacting protein. (180 aa)
TPRTranslocated promoter region, nuclear basket protein. (2439 aa)
TNPO3Transportin 3. (923 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (925 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
KPNA7Importin subunit alpha; Functions in nuclear protein import. (515 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
PPP3R1Uncharacterized protein. (189 aa)
GLI3GLI family zinc finger 3. (1579 aa)
NUP54Testis cDNA, clone: QtsA-18807, similar to human nucleoporin 54kDa (NUP54). (508 aa)
CBLBCbl proto-oncogene B. (982 aa)
STK4Serine/threonine kinase 4. (487 aa)
RANBP2RAN binding protein 2. (3221 aa)
KPNB1Karyopherin subunit beta 1. (875 aa)
FAM53BFamily with sequence similarity 53 member B. (425 aa)
ENSMFAP00000012963NTF2 domain-containing protein. (127 aa)
AKIRIN2Akirin 2. (205 aa)
PRICKLE1Prickle planar cell polarity protein 1. (831 aa)
NXT1Nuclear transport factor 2 like export factor 1. (140 aa)
NFKBIANF-kappa-B inhibitor alpha. (317 aa)
IPO8Importin 8. (1037 aa)
LOC102126330Importin subunit alpha; Functions in nuclear protein import. (504 aa)
NXT2Nuclear transport factor 2 like export factor 2. (197 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (715 aa)
NUP35Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (326 aa)
RANBP6Uncharacterized protein. (381 aa)
IPO4Importin 4. (1087 aa)
STK3Serine/threonine kinase 3. (519 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2442 aa)
BCL3BCL3 transcription coactivator. (435 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
POM121CUncharacterized protein. (1225 aa)
NUTF2Nuclear transport factor 2. (127 aa)
IPO7Importin 7. (973 aa)
IPO5Importin 5. (1217 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PMLPromyelocytic leukemia. (882 aa)
HEATR3HEAT repeat containing 3. (680 aa)
FAM53CFamily with sequence similarity 53 member C. (392 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
TNPO2Transportin 2. (907 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
NUP214Nucleoporin 214. (2090 aa)
KPNA5Importin subunit alpha; Functions in nuclear protein import. (539 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
NUP153Nucleoporin 153. (1492 aa)
NUP62CLNsp1_C domain-containing protein. (238 aa)
ENSMFAP00000039407Importin subunit alpha; Functions in nuclear protein import. (446 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
NF1Neurofibromin 1. (2849 aa)
KPNA4Importin subunit alpha; Functions in nuclear protein import. (521 aa)
ENSMFAP00000042185NTF2 domain-containing protein. (119 aa)
NUP155Nucleoporin 155. (1449 aa)
TRAF3IP2TRAF3 interacting protein 2. (572 aa)
GCKRGlucokinase regulator. (625 aa)
KPNA6Importin subunit alpha; Functions in nuclear protein import. (549 aa)
NOTCH1Notch receptor 1. (2556 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (985 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa)
ENSMFAP00000038879GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (206 aa)
FAM53AFamily with sequence similarity 53 member A. (398 aa)
LOC102119659Uncharacterized protein. (343 aa)
RANBP17RAN binding protein 17. (1088 aa)
TMCO6Transmembrane and coiled-coil domains 6. (493 aa)
LOC107127914Uncharacterized protein. (346 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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