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PLPP2 PLPP2 ASAH1 ASAH1 ACER3 ACER3 ASAH2 ASAH2 ACER2 ACER2 SGPP1 SGPP1 NAAA NAAA SPTLC3 SPTLC3 ACER1 ACER1 SPHK1 SPHK1 SGPP2 SGPP2 PLPP1 PLPP1 SPTSSB SPTSSB SPTLC1 SPTLC1 PLPP3 PLPP3 SPHK2 SPHK2 TMEM130 TMEM130 ABCA2 ABCA2 SPTSSA SPTSSA SPTLC2 SPTLC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLPP2Phospholipid phosphatase 2. (302 aa)
ASAH1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] (411 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)
ASAH2Neutral ceramidase. (780 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (441 aa)
NAAAN-acylethanolamine acid amidase; Belongs to the acid ceramidase family. (363 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (552 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
SPHK1Sphingosine kinase 1. (470 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (399 aa)
PLPP1Phospholipid phosphatase 1. (285 aa)
SPTSSBSerine palmitoyltransferase small subunit B. (76 aa)
SPTLC1Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] (500 aa)
PLPP3acidPPc domain-containing protein. (353 aa)
SPHK2Sphingosine kinase 2. (653 aa)
TMEM130Transmembrane protein 130. (352 aa)
ABCA2ATP binding cassette subfamily A member 2. (2469 aa)
SPTSSASerine palmitoyltransferase small subunit A. (71 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (555 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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