STRINGSTRING
F2R F2R CX3CR1 CX3CR1 TACR1 TACR1 NPR3 NPR3 DRD2 DRD2 NMUR2 NMUR2 NTSR2 NTSR2 GNA14 GNA14 P2RY11 P2RY11 PTH1R PTH1R LPAR1-2 LPAR1-2 LHCGR LHCGR TRHR TRHR ADRA1A ADRA1A FPR2 FPR2 P2RY2 P2RY2 FSHR FSHR GPR65 GPR65 P2RY6 P2RY6 GPR174 GPR174 P2RY10 P2RY10 GPR55 GPR55 LPAR4 LPAR4 PLCE1 PLCE1 S1PR1 S1PR1 DRD1 DRD1 CMKLR1 CMKLR1 GPR20 GPR20 GPR4 GPR4 P2RY4 P2RY4 GPR139 GPR139 P2RY1 P2RY1 HTR2C HTR2C OPRM1 OPRM1 ENSMFAP00000004742 ENSMFAP00000004742 OPRL1 OPRL1 GNG13 GNG13 GPR157 GPR157 HOMER1 HOMER1 GPR83 GPR83 LPAR6 LPAR6 VIP VIP PTGER3 PTGER3 ANO1 ANO1 GRM1 GRM1 EDN1 EDN1 GNA11 GNA11 HCRTR2 HCRTR2 GALR2 GALR2 CASR CASR ESR1 ESR1 GNA15 GNA15 F2RL2 F2RL2 GRPR GRPR HCRT HCRT NMUR1 NMUR1 F2RL1 F2RL1 OPRD1 OPRD1 F2RL3 F2RL3 GRM5 GRM5 LPAR1 LPAR1 CCKBR CCKBR NMBR NMBR ADRA1D ADRA1D GPR32 GPR32 CCKAR CCKAR HTR2B HTR2B PLCB2 PLCB2 DRD3 DRD3 GPR17 GPR17 GPR35 GPR35 FFAR4 FFAR4 TGM2 TGM2 OPRK1 OPRK1 CALCA CALCA AGTR1 AGTR1 ACTN2 ACTN2 ADRA1B ADRA1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
CX3CR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (386 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
NPR3Natriuretic peptide receptor 3. (541 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
NMUR2Neuromedin U receptor 2; Belongs to the G-protein coupled receptor 1 family. (408 aa)
NTSR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (405 aa)
GNA14G protein subunit alpha 14. (355 aa)
P2RY11Purinergic receptor P2Y11; Belongs to the G-protein coupled receptor 1 family. (374 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
LPAR1-2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (378 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (703 aa)
TRHRThyrotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (398 aa)
ADRA1AAdrenoceptor alpha 1A. (462 aa)
FPR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (351 aa)
P2RY2Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (377 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
GPR65G protein-coupled receptor 65; Belongs to the G-protein coupled receptor 1 family. (337 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
GPR174G protein-coupled receptor 174. (333 aa)
P2RY10P2Y receptor family member 10. (339 aa)
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (319 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
CMKLR1Chemerin chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
GPR20G protein-coupled receptor 20; Belongs to the G-protein coupled receptor 1 family. (359 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
P2RY4Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (365 aa)
GPR139G protein-coupled receptor 139. (353 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (455 aa)
ENSMFAP00000004742G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (347 aa)
OPRL1Opioid related nociceptin receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
GPR157G protein-coupled receptor 157. (335 aa)
HOMER1Homer scaffold protein 1. (358 aa)
GPR83G protein-coupled receptor 83; Belongs to the G-protein coupled receptor 1 family. (423 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa)
VIPVasoactive intestinal peptide. (170 aa)
PTGER3Prostaglandin E receptor 3. (410 aa)
ANO1Anoctamin. (986 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
EDN1Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (211 aa)
GNA11G protein subunit alpha 11. (359 aa)
HCRTR2Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family. (444 aa)
GALR2Galanin receptor 2; Belongs to the G-protein coupled receptor 1 family. (387 aa)
CASRCalcium sensing receptor. (1078 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
GNA15G protein subunit alpha 15. (330 aa)
F2RL2Coagulation factor II thrombin receptor like 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
GRPRGastrin releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)
NMUR1Neuromedin U receptor 1; Belongs to the G-protein coupled receptor 1 family. (426 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (385 aa)
GRM5Glutamate metabotropic receptor 5. (1212 aa)
LPAR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (513 aa)
NMBRNeuromedin B receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
ADRA1DAdrenoceptor alpha 1D. (462 aa)
GPR32G protein-coupled receptor 32; Belongs to the G-protein coupled receptor 1 family. (341 aa)
CCKARCholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (426 aa)
GPR17G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (371 aa)
GPR35G protein-coupled receptor 35; Belongs to the G-protein coupled receptor 1 family. (327 aa)
FFAR4Free fatty acid receptor 4; Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega- 3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)- coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates [...] (377 aa)
TGM2Transglutaminase 2. (687 aa)
OPRK1Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
ACTN2Actinin alpha 2. (894 aa)
ADRA1BAdrenoceptor alpha 1B. (518 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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