STRINGSTRING
UNC13B UNC13B STXBP3 STXBP3 CPLX4 CPLX4 NT5DC3 NT5DC3 LIN7A LIN7A LRRC1 LRRC1 SNAP23 SNAP23 NF1 NF1 LIN7B LIN7B CTBP2 CTBP2 NRXN1 NRXN1 SYT9 SYT9 CADPS CADPS CPLX2 CPLX2 SV2A SV2A RIMS1 RIMS1 RAP1A RAP1A SYT8 SYT8 BRSK1 BRSK1 SYT1 SYT1 UNC13C UNC13C UNC13A UNC13A SYT5 SYT5 NRXN2 NRXN2 SNAPIN SNAPIN PDZD11 PDZD11 SYN1 SYN1 NLGN1 NLGN1 RIMS3 RIMS3 SCRIB SCRIB RPH3A RPH3A SYT12 SYT12 SYN2 SYN2 PTPRN2 PTPRN2 LIN7C LIN7C CPLX3 CPLX3 NR4A1 NR4A1 STX4 STX4 PIP5K1C PIP5K1C WNT7A WNT7A STX2 STX2 STXBP2 STXBP2 OTOF OTOF SYT7 SYT7 SYT4 SYT4 ERC2 ERC2 NT5DC2 NT5DC2 DVL1 DVL1 PRRT2 PRRT2 P2RX7 P2RX7 STX1B STX1B SYN3 SYN3 NRXN3 NRXN3 DOC2A DOC2A RIMS2 RIMS2 LOC102127640 LOC102127640 PPT1 PPT1 SYNJ1 SYNJ1 ENSMFAP00000012353 ENSMFAP00000012353 STX11 STX11 PPFIA3 PPFIA3 LOC102136620 LOC102136620 ASIC1 ASIC1 BRAF BRAF SNAP47 SNAP47 PCLO PCLO LOC102124997 LOC102124997 STX1A STX1A BLOC1S6 BLOC1S6 DGKI DGKI VAMP1 VAMP1 DOC2B DOC2B CDK5 CDK5 RPH3AL RPH3AL SNAP25 SNAP25 DNAJC5 DNAJC5 SYT2 SYT2 CADPS2 CADPS2 HRH3 HRH3 PSEN1 PSEN1 ENSMFAP00000002252 ENSMFAP00000002252 NAPA NAPA STX3 STX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UNC13BUncharacterized protein. (4336 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
CPLX4Complexin 4. (160 aa)
NT5DC35'-nucleotidase domain containing 3. (546 aa)
LIN7AProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
NF1Neurofibromin 1. (2849 aa)
LIN7BProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (207 aa)
CTBP2C-terminal binding protein 2. (985 aa)
NRXN1Neurexin 1. (1507 aa)
SYT9Synaptotagmin 9. (491 aa)
CADPSCalcium dependent secretion activator. (1345 aa)
CPLX2Uncharacterized protein. (134 aa)
SV2ASynaptic vesicle glycoprotein 2A; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). (742 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1692 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
SYT8Synaptotagmin 8. (387 aa)
BRSK1Protein kinase domain-containing protein. (286 aa)
SYT1Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-in [...] (422 aa)
UNC13CUnc-13 homolog C. (2216 aa)
UNC13AUnc-13 homolog A. (1592 aa)
SYT5Brain cDNA, clone: QccE-17821, similar to human synaptotagmin V (SYT5). (386 aa)
NRXN2Neurexin 2. (1713 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
PDZD11PDZ domain-containing protein. (140 aa)
SYN1Synapsin I. (705 aa)
NLGN1Neuroligin 1. (823 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (308 aa)
SCRIBScribble planar cell polarity protein. (1662 aa)
RPH3ARabphilin 3A. (694 aa)
SYT12Synaptotagmin 12. (421 aa)
SYN2Synapsin II. (584 aa)
PTPRN2Protein tyrosine phosphatase receptor type N2. (977 aa)
LIN7CProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
CPLX3Complexin 3. (158 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (670 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (171 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (708 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
STX2Syntaxin 2; Belongs to the syntaxin family. (277 aa)
STXBP2Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (593 aa)
OTOFOtoferlin. (1997 aa)
SYT7Synaptotagmin 7. (686 aa)
SYT4Synaptotagmin 4. (425 aa)
ERC2ELKS/RAB6-interacting/CAST family member 2. (957 aa)
NT5DC25'-nucleotidase domain containing 2. (528 aa)
DVL1Dishevelled segment polarity protein 1. (673 aa)
PRRT2Proline rich transmembrane protein 2. (340 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (288 aa)
SYN3Synapsin III. (580 aa)
NRXN3Neurexin 3. (1664 aa)
DOC2ADouble C2-like domain-containing protein. (400 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1367 aa)
LOC102127640Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (437 aa)
PPT1Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (By similarity). (335 aa)
SYNJ1Synaptojanin 1. (1548 aa)
ENSMFAP00000012353Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (435 aa)
STX11Syntaxin 11; Belongs to the syntaxin family. (287 aa)
PPFIA3PTPRF interacting protein alpha 3. (1194 aa)
LOC102136620Uncharacterized protein. (64 aa)
ASIC1Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (562 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
SNAP47Synaptosome associated protein 47. (463 aa)
PCLOPiccolo presynaptic cytomatrix protein. (5181 aa)
LOC102124997Uncharacterized protein. (387 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (288 aa)
BLOC1S6Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (172 aa)
DGKIDiacylglycerol kinase. (1079 aa)
VAMP1Vesicle associated membrane protein 1. (118 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
RPH3ALRabphilin 3A like (without C2 domains). (294 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
DNAJC5DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
SYT2Synaptotagmin 2. (419 aa)
CADPS2Calcium dependent secretion activator 2. (1209 aa)
HRH3Histamine receptor H3; Belongs to the G-protein coupled receptor 1 family. (413 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (467 aa)
ENSMFAP00000002252UBA domain-containing protein. (444 aa)
NAPAAlpha-soluble NSF attachment protein. (295 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (302 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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