STRINGSTRING
BSN BSN NPAS4 NPAS4 ZDHHC12 ZDHHC12 NRG1 NRG1 CDK5 CDK5 LRRTM3 LRRTM3 DNM3 DNM3 SLITRK6 SLITRK6 SLITRK1 SLITRK1 ENSMFAP00000001834 ENSMFAP00000001834 EFNB2 EFNB2 GABRG2 GABRG2 ENSMFAP00000005493 ENSMFAP00000005493 IL1RAPL2 IL1RAPL2 GABRA1 GABRA1 APP APP PCLO PCLO ENSMFAP00000008168 ENSMFAP00000008168 GJA10 GJA10 ASIC2 ASIC2 FZD5 FZD5 ADGRF1 ADGRF1 FLRT3 FLRT3 HAPLN4 HAPLN4 SLITRK3 SLITRK3 FGF13 FGF13 GPM6A GPM6A NRXN3 NRXN3 SHANK2 SHANK2 ENSMFAP00000017173 ENSMFAP00000017173 CBLN4 CBLN4 PTPRD PTPRD DBNL DBNL CDH1 CDH1 SDK1 SDK1 CBLN2 CBLN2 MECP2 MECP2 DSCAM DSCAM GABRB3 GABRB3 GNPAT GNPAT DVL1 DVL1 PLXNB1 PLXNB1 PLXNB2 PLXNB2 FBXO45 FBXO45 KIRREL3 KIRREL3 GRID2 GRID2 GHRL GHRL SDK2 SDK2 ENSMFAP00000025331 ENSMFAP00000025331 MAP1B MAP1B NRCAM NRCAM PCDH17 PCDH17 WNT7A WNT7A RYK RYK IGFN1 IGFN1 WNT3A WNT3A ERBB4 ERBB4 NLGN2 NLGN2 SPTBN2 SPTBN2 NLGN1 NLGN1 LGI2 LGI2 NPTN NPTN NRXN2 NRXN2 EPHB2 EPHB2 PTEN PTEN CBLN1 CBLN1 CRKL CRKL BDNF BDNF LRP4 LRP4 SRGAP2 SRGAP2 WNT5A WNT5A GABRA2 GABRA2 OBSL1 OBSL1 DNER DNER ACHE ACHE NLGN4Y NLGN4Y SDCBP SDCBP SPOCK2 SPOCK2 NRXN1 NRXN1 SLC25A46 SLC25A46 ENSMFAP00000040580 ENSMFAP00000040580 ENSMFAP00000040832 ENSMFAP00000040832 RAB29 RAB29 VPS35 VPS35 LRRC4 LRRC4 NTNG2 NTNG2 CNTN5 CNTN5 GABRB2 GABRB2 FARP1 FARP1 ADGRL3 ADGRL3 SHANK3 SHANK3 IGSF22 IGSF22 PLXND1 PLXND1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BSNBassoon presynaptic cytomatrix protein. (3938 aa)
NPAS4Neuronal PAS domain protein 4. (802 aa)
ZDHHC12Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (267 aa)
NRG1Neuregulin 1. (713 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
LRRTM3Leucine-rich repeat transmembrane neuronal protein 3; May play a role in the development and maintenance of the vertebrate nervous system. Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity); Belongs to the LRRTM family. (581 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
SLITRK6SLIT and NTRK like family member 6. (841 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
ENSMFAP00000001834COesterase domain-containing protein. (221 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (335 aa)
GABRG2Gamma-aminobutyric acid type A receptor gamma2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (515 aa)
ENSMFAP00000005493COesterase domain-containing protein. (295 aa)
IL1RAPL2Interleukin 1 receptor accessory protein like 2. (686 aa)
GABRA1Gamma-aminobutyric acid receptor subunit alpha-1; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present [...] (490 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
PCLOPiccolo presynaptic cytomatrix protein. (5181 aa)
ENSMFAP00000008168Uncharacterized protein. (511 aa)
GJA10Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (492 aa)
ASIC2Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (528 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
ADGRF1Adhesion G protein-coupled receptor F1; Belongs to the G-protein coupled receptor 2 family. (903 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
HAPLN4Hyaluronan and proteoglycan link protein 4. (402 aa)
SLITRK3SLIT and NTRK like family member 3. (979 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
GPM6AUncharacterized protein. (278 aa)
NRXN3Neurexin 3. (1664 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1742 aa)
ENSMFAP00000017173PDZ domain-containing protein. (255 aa)
CBLN4Cerebellin 4 precursor. (201 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1912 aa)
DBNLUncharacterized protein. (419 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
SDK1Sidekick cell adhesion molecule 1. (2135 aa)
CBLN2Cerebellin 2 precursor. (224 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
DSCAMDS cell adhesion molecule. (1880 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (529 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (683 aa)
DVL1Dishevelled segment polarity protein 1. (673 aa)
PLXNB1Plexin B1. (2140 aa)
PLXNB2Plexin B2. (1859 aa)
FBXO45F-box protein 45. (320 aa)
KIRREL3Kirre like nephrin family adhesion molecule 3. (788 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
SDK2Sidekick cell adhesion molecule 2. (2172 aa)
ENSMFAP00000025331Uncharacterized protein. (259 aa)
MAP1BMicrotubule associated protein 1B. (2468 aa)
NRCAMNeuronal cell adhesion molecule. (1304 aa)
PCDH17Protocadherin 17. (1187 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
RYKReceptor like tyrosine kinase. (585 aa)
IGFN1Immunoglobulin like and fibronectin type III domain containing 1. (3235 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
NLGN2Neuroligin 2. (849 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2390 aa)
NLGN1Neuroligin 1. (823 aa)
LGI2Leucine rich repeat LGI family member 2. (545 aa)
NPTNNeuroplastin. (398 aa)
NRXN2Neurexin 2. (1713 aa)
EPHB2Uncharacterized protein. (468 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CBLN1Cerebellin 1 precursor. (193 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
LRP4LDL receptor related protein 4. (1913 aa)
SRGAP2Uncharacterized protein. (1071 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
GABRA2Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (511 aa)
OBSL1Obscurin like 1. (1896 aa)
DNERDelta/notch like EGF repeat containing. (709 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (631 aa)
NLGN4YNeuroligin 4 Y-linked. (873 aa)
SDCBPUncharacterized protein. (324 aa)
SPOCK2SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (424 aa)
NRXN1Neurexin 1. (1507 aa)
SLC25A46Solute carrier family 25 member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (418 aa)
ENSMFAP00000040580Uncharacterized protein. (507 aa)
ENSMFAP00000040832Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
RAB29RAB29, member RAS oncogene family. (203 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
LRRC4Leucine rich repeat containing 4. (633 aa)
NTNG2Netrin G2. (530 aa)
CNTN5Contactin 5. (1100 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
FARP1FERM, ARH/RhoGEF and pleckstrin domain protein 1. (1044 aa)
ADGRL3Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. (1580 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1596 aa)
IGSF22Immunoglobulin superfamily member 22. (1326 aa)
PLXND1Uncharacterized protein. (52 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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