STRINGSTRING
GPR88 GPR88 FYN FYN PTRHD1 PTRHD1 UBE3A UBE3A STRA6 STRA6 ENSMFAP00000001834 ENSMFAP00000001834 TACR2 TACR2 ENSMFAP00000002252 ENSMFAP00000002252 TNR TNR SLC8A2 SLC8A2 SNAP25 SNAP25 MAP1A MAP1A MAPK8IP2 MAPK8IP2 PRKN PRKN C1QL1 C1QL1 CDK5 CDK5 ARC ARC NPAS4 NPAS4 ENSMFAP00000005493 ENSMFAP00000005493 VDAC1 VDAC1 SLC8A3 SLC8A3 CTNS CTNS DGKI DGKI SLC12A5 SLC12A5 RELN RELN ATAD1 ATAD1 SYNGAP1 SYNGAP1 YTHDF1 YTHDF1 KIT KIT APP APP SPECC1 SPECC1 UBA6 UBA6 BRAF BRAF ARF4 ARF4 GABRA5 GABRA5 ASIC1 ASIC1 SLC6A1 SLC6A1 TSC1 TSC1 TPBG TPBG DRD5 DRD5 RAG1 RAG1 FOXB1 FOXB1 FOS FOS SYNJ1 SYNJ1 BTG2 BTG2 CLDN5 CLDN5 NOG NOG MEIS2 MEIS2 PTGS2 PTGS2 NEUROD2 NEUROD2 PPT1 PPT1 ATXN1L ATXN1L HRH1 HRH1 NTSR1 NTSR1 ENSMFAP00000014793 ENSMFAP00000014793 FGF13 FGF13 GRIN1 GRIN1 SHANK1 SHANK1 NRXN3 NRXN3 TTC36 TTC36 SHANK2 SHANK2 ENSMFAP00000016996 ENSMFAP00000016996 ENSMFAP00000017863 ENSMFAP00000017863 NETO1 NETO1 DLG4 DLG4 HIF1A HIF1A DDHD2 DDHD2 ATXN1 ATXN1 IFT20 IFT20 PPP3CB PPP3CB PAK6 PAK6 TACO1 TACO1 MECP2 MECP2 PDE1B PDE1B EIF2AK4 EIF2AK4 TPBGL TPBGL ABCC8 ABCC8 CHST10 CHST10 SRF SRF CSMD1 CSMD1 CLN8 CLN8 DRD2 DRD2 PLCB1 PLCB1 CSMD2 CSMD2 TACR1 TACR1 KALRN KALRN SORCS3 SORCS3 LGMN LGMN NPS NPS NDRG4 NDRG4 PTN PTN NTRK2 NTRK2 FOSL1 FOSL1 PPP1R1B PPP1R1B ENSMFAP00000029116 ENSMFAP00000029116 JPH3 JPH3 TANC1 TANC1 TH TH EPM2A EPM2A CIC CIC HTT HTT TBR1 TBR1 NPTN NPTN GRIN2A GRIN2A ENSMFAP00000032402 ENSMFAP00000032402 NRXN2 NRXN2 CHRNB2 CHRNB2 ABCA7 ABCA7 EPHB2 EPHB2 BRSK1 BRSK1 ENSMFAP00000034148 ENSMFAP00000034148 KRAS KRAS ENSMFAP00000034629 ENSMFAP00000034629 ADGRB3 ADGRB3 RAPGEF3 RAPGEF3 LRRN4 LRRN4 GRM5 GRM5 ENSMFAP00000036680 ENSMFAP00000036680 SLC7A11 SLC7A11 JPH4 JPH4 SLC1A1 SLC1A1 CNTN2 CNTN2 DKK1 DKK1 ADCY3 ADCY3 NRXN1 NRXN1 RGS14 RGS14 B4GALT2 B4GALT2 PAK5 PAK5 NF1 NF1 CNTNAP2 CNTNAP2 ZZEF1 ZZEF1 ENSMFAP00000040832 ENSMFAP00000040832 ATP8A1 ATP8A1 DBH DBH PPP1R9B PPP1R9B PRKAR2B PRKAR2B AAAS AAAS ENSMFAP00000042133 ENSMFAP00000042133 ELAVL4 ELAVL4 TAFA2 TAFA2 EN1 EN1 SYT11 SYT11 GIT1 GIT1 NPTX2 NPTX2 ABL1 ABL1 SHANK3 SHANK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPR88G protein-coupled receptor 88. (384 aa)
FYNTyrosine-protein kinase. (537 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
STRA6Stimulated by retinoic acid 6. (707 aa)
ENSMFAP00000001834COesterase domain-containing protein. (221 aa)
TACR2Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (398 aa)
ENSMFAP00000002252UBA domain-containing protein. (444 aa)
TNRTenascin R. (1358 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (753 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
MAP1AMicrotubule associated protein 1A. (3042 aa)
MAPK8IP2Mitogen-activated protein kinase 8 interacting protein 2. (824 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
C1QL1Complement C1q like 1. (258 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ARCActivity regulated cytoskeleton associated protein. (471 aa)
NPAS4Neuronal PAS domain protein 4. (802 aa)
ENSMFAP00000005493COesterase domain-containing protein. (295 aa)
VDAC1Uncharacterized protein. (289 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
CTNSCystinosin, lysosomal cystine transporter. (400 aa)
DGKIDiacylglycerol kinase. (1079 aa)
SLC12A5Solute carrier family 12 member 5. (1139 aa)
RELNReelin. (3464 aa)
ATAD1AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1343 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (559 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
SPECC1Sperm antigen with calponin homology and coiled-coil domains 1. (1029 aa)
UBA6Ubiquitin like modifier activating enzyme 6. (1052 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
ARF4ADP ribosylation factor 4; Belongs to the small GTPase superfamily. Arf family. (180 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
ASIC1Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (562 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
TSC1TSC complex subunit 1. (1168 aa)
TPBGTrophoblast glycoprotein; May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. (420 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (478 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
FOXB1Forkhead box B1. (325 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SYNJ1Synaptojanin 1. (1548 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MEIS2Meis homeobox 2. (477 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
PPT1Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (By similarity). (335 aa)
ATXN1LAtaxin 1 like. (689 aa)
HRH1Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (487 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
ENSMFAP00000014793Uncharacterized protein. (146 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (2171 aa)
NRXN3Neurexin 3. (1664 aa)
TTC36Tetratricopeptide repeat domain 36. (189 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1742 aa)
ENSMFAP00000016996HECT domain-containing protein. (736 aa)
ENSMFAP00000017863Uncharacterized protein. (235 aa)
NETO1Uncharacterized protein. (533 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
HIF1AUncharacterized protein. (831 aa)
DDHD2DDHD domain containing 2. (630 aa)
ATXN1Ataxin 1. (820 aa)
IFT20Uncharacterized protein. (156 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
TACO1Translational activator of cytochrome c oxidase I. (297 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
PDE1BPhosphodiesterase. (538 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1248 aa)
TPBGLTrophoblast glycoprotein like. (377 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
CHST10Carbohydrate sulfotransferase. (356 aa)
SRFSerum response factor. (508 aa)
CSMD1CUB and Sushi multiple domains 1. (3565 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (286 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CSMD2CUB and Sushi multiple domains 2. (3631 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
KALRNKalirin RhoGEF kinase. (2986 aa)
SORCS3Sortilin related VPS10 domain containing receptor 3. (1222 aa)
LGMNLegumain; Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). (433 aa)
NPSNeuropeptide S. (89 aa)
NDRG4NDRG family member 4. (414 aa)
PTNPleiotrophin. (172 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
ENSMFAP00000029116Uncharacterized protein. (246 aa)
JPH3Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (748 aa)
TANC1Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1. (1860 aa)
THTyrosine hydroxylase. (529 aa)
EPM2AEPM2A glucan phosphatase, laforin. (331 aa)
CICCapicua transcriptional repressor. (2514 aa)
HTTHuntingtin. (3118 aa)
TBR1T-box brain transcription factor 1. (682 aa)
NPTNNeuroplastin. (398 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
ENSMFAP00000032402AAA domain-containing protein; Belongs to the AAA ATPase family. (342 aa)
NRXN2Neurexin 2. (1713 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (502 aa)
ABCA7ATP binding cassette subfamily A member 7. (2148 aa)
EPHB2Uncharacterized protein. (468 aa)
BRSK1Protein kinase domain-containing protein. (286 aa)
ENSMFAP00000034148Uncharacterized protein. (376 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ENSMFAP00000034629Uncharacterized protein. (122 aa)
ADGRB3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1522 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
LRRN4Leucine rich repeat neuronal 4. (737 aa)
GRM5Glutamate metabotropic receptor 5. (1212 aa)
ENSMFAP00000036680RWD domain-containing protein. (136 aa)
SLC7A11Solute carrier family 7 member 11. (501 aa)
JPH4Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (628 aa)
SLC1A1Solute carrier family 1 member 1. (524 aa)
CNTN2Contactin 2. (1040 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
NRXN1Neurexin 1. (1507 aa)
RGS14Regulator of G protein signaling 14. (566 aa)
B4GALT2Beta-1,4-galactosyltransferase 2. (400 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
NF1Neurofibromin 1. (2849 aa)
CNTNAP2Contactin associated protein like 2. (1331 aa)
ZZEF1Zinc finger ZZ-type and EF-hand domain containing 1. (2962 aa)
ENSMFAP00000040832Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
ATP8A1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1164 aa)
DBHDopamine beta-hydroxylase. (620 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (818 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (421 aa)
AAASAladin WD repeat nucleoporin. (546 aa)
ENSMFAP00000042133HECT domain-containing protein. (55 aa)
ELAVL4ELAV-like protein; Belongs to the RRM elav family. (402 aa)
TAFA2Uncharacterized protein. (155 aa)
EN1Homeobox protein engrailed-like. (394 aa)
SYT11Uncharacterized protein. (431 aa)
GIT1GIT ArfGAP 1. (776 aa)
NPTX2Neuronal pentraxin 2. (434 aa)
ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase. (901 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1596 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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