STRINGSTRING
IER5L IER5L ENSMFAP00000000815 ENSMFAP00000000815 IRAK1 IRAK1 CRYAA CRYAA CASQ1 CASQ1 HSBP1L1 HSBP1L1 ASIC3 ASIC3 TRPM2 TRPM2 NOS3 NOS3 SLU7 SLU7 TRPV1 TRPV1 NOS1 NOS1 ANO1 ANO1 TCIM TCIM CETN1 CETN1 IER5 IER5 SCARA5 SCARA5 G7PFU7_MACFA G7PFU7_MACFA CD14 CD14 PTGS2 PTGS2 VCP VCP STAC STAC ENSMFAP00000014199 ENSMFAP00000014199 PIRT PIRT HSF1 HSF1 IGF1 IGF1 SUMO1 SUMO1 TRPV2 TRPV2 MICB MICB DNAJA4 DNAJA4 GCLC GCLC FGF1 FGF1 MAP2K7 MAP2K7 AKT1 AKT1 POLR2D POLR2D DNAJA1 DNAJA1 TRPV4 TRPV4 ENSMFAP00000018412 ENSMFAP00000018412 DHX36 DHX36 IGFBP7 IGFBP7 TPR TPR ENSMFAP00000020087 ENSMFAP00000020087 THBS1 THBS1 TP53INP1 TP53INP1 HTRA2 HTRA2 HIKESHI HIKESHI TFEC TFEC BAG3 BAG3 IL1A IL1A SCN2B SCN2B HSPA2 HSPA2 LYN LYN RPS6KB1 RPS6KB1 TACR1 TACR1 EIF2B2 EIF2B2 EIF2B4 EIF2B4 ATXN3 ATXN3 P2RX3 P2RX3 ENSMFAP00000027910 ENSMFAP00000027910 HSPB1 HSPB1 ENSMFAP00000028227 ENSMFAP00000028227 EIF2B5 EIF2B5 PSIP1 PSIP1 PMP22 PMP22 SUMO1-2 SUMO1-2 CALCA CALCA ARPP21 ARPP21 TRPV3 TRPV3 SLC52A3 SLC52A3 STUB1 STUB1 DNAJA3 DNAJA3 ST8SIA1 ST8SIA1 HDAC2 HDAC2 MKI67 MKI67 HSP90AA1 HSP90AA1 DNAJA2 DNAJA2 HSPB2 HSPB2 LRP11 LRP11 RBBP7 RBBP7 HSPA6 HSPA6 ENSMFAP00000036744 ENSMFAP00000036744 PKLR PKLR DAXX DAXX NF1 NF1 ENSMFAP00000040719 ENSMFAP00000040719 SOD1 SOD1 YWHAE YWHAE CXCL12 CXCL12 MTOR MTOR CPB2 CPB2 HSPB6 HSPB6 CLPB CLPB CRNN CRNN HMOX1 HMOX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IER5LImmediate early response 5 like. (364 aa)
ENSMFAP00000000815Small ubiquitin-related modifier. (121 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (662 aa)
CRYAASHSP domain-containing protein; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (172 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (398 aa)
HSBP1L1Heat shock factor binding protein 1 like 1. (74 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (541 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1511 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
SLU7Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family. (586 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
ANO1Anoctamin. (986 aa)
TCIMTranscriptional and immune response regulator. (106 aa)
CETN1Centrin 1. (172 aa)
IER5Immediate early response 5. (327 aa)
SCARA5Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the de [...] (496 aa)
G7PFU7_MACFASmall ubiquitin-related modifier. (101 aa)
CD14Uncharacterized protein. (384 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
STACSH3 and cysteine rich domain. (402 aa)
ENSMFAP00000014199HATPase_c domain-containing protein. (307 aa)
PIRTPhosphoinositide interacting regulator of transient receptor potential channels. (137 aa)
HSF1Heat shock transcription factor 1. (529 aa)
IGF1Insulin like growth factor 1. (159 aa)
SUMO1Ubiquitin-like domain-containing protein. (146 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (764 aa)
MICBIg-like domain-containing protein. (386 aa)
DNAJA4DnaJ heat shock protein family (Hsp40) member A4. (426 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
DNAJA1Uncharacterized protein. (397 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (823 aa)
ENSMFAP00000018412HATPase_c domain-containing protein. (644 aa)
DHX36DEAH-box helicase 36. (1008 aa)
IGFBP7Insulin like growth factor binding protein 7. (282 aa)
TPRTranslocated promoter region, nuclear basket protein. (2439 aa)
ENSMFAP00000020087Josephin domain-containing protein. (314 aa)
THBS1Thrombospondin 1. (1173 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (241 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (197 aa)
TFECTranscription factor EC. (347 aa)
BAG3BCL2 associated athanogene 3. (575 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (271 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (641 aa)
LYNTyrosine-protein kinase. (512 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
EIF2B2Uncharacterized protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (543 aa)
ATXN3Josephin domain-containing protein. (375 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (398 aa)
ENSMFAP00000027910Rad60-SLD domain-containing protein. (81 aa)
HSPB1SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
ENSMFAP00000028227DnaJ_C domain-containing protein. (291 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (721 aa)
PSIP1PC4 and SFRS1 interacting protein 1. (530 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
SUMO1-2Rad60-SLD domain-containing protein. (67 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
ARPP21cAMP regulated phosphoprotein 21. (813 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (763 aa)
SLC52A3Solute carrier family 52 member 3. (469 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
MKI67Marker of proliferation Ki-67. (3249 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (831 aa)
DNAJA2DnaJ heat shock protein family (Hsp40) member A2. (412 aa)
HSPB2SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (182 aa)
LRP11LDL receptor related protein 11. (468 aa)
RBBP7Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and [...] (469 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (600 aa)
ENSMFAP00000036744Uncharacterized protein. (90 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
DAXXDeath domain associated protein. (740 aa)
NF1Neurofibromin 1. (2849 aa)
ENSMFAP0000004071914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (256 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CPB2Carboxypeptidase B2. (423 aa)
HSPB6Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family. (160 aa)
CLPBANK_REP_REGION domain-containing protein. (704 aa)
CRNNCornulin. (510 aa)
HMOX1Uncharacterized protein. (288 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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