STRINGSTRING
PPP1R18 PPP1R18 HDAC2 HDAC2 SLITRK6 SLITRK6 LOC102129056 LOC102129056 ENSMFAP00000002824 ENSMFAP00000002824 KRT8 KRT8 KRT83 KRT83 PCDH15 PCDH15 PALLD PALLD IFT74 IFT74 TMEM79 TMEM79 PLS1 PLS1 INTU INTU ENSMFAP00000045924 ENSMFAP00000045924 NOTCH1 NOTCH1 EVPL EVPL ENSMFAP00000043974 ENSMFAP00000043974 ADAM9 ADAM9 KRT82 KRT82 IRF6 IRF6 PITX2 PITX2 ASAH1 ASAH1 KRT16 KRT16 EZH2 EZH2 DLL1 DLL1 PTCH2 PTCH2 LATS1 LATS1 LRRC1 LRRC1 CYP26B1 CYP26B1 ABCA12 ABCA12 KRT81 KRT81 SOD1 SOD1 ENSMFAP00000040751 ENSMFAP00000040751 SLC44A4 SLC44A4 MYO6 MYO6 LOC102136364 LOC102136364 TXNIP TXNIP MED1 MED1 UGCG UGCG CDH3 CDH3 SHARPIN SHARPIN SEC24B SEC24B REST REST CLIC4 CLIC4 OVOL3 OVOL3 KRT5 KRT5 POU4F3 POU4F3 ERCC2 ERCC2 JAG2 JAG2 GRXCR1 GRXCR1 KRT85 KRT85 PDZD7 PDZD7 LOC102128687 LOC102128687 ENSMFAP00000036760 ENSMFAP00000036760 KRT84 KRT84 FLNB FLNB AKR1C1-2 AKR1C1-2 WNT5A WNT5A ENSMFAP00000035413 ENSMFAP00000035413 LHFPL5 LHFPL5 PPP3CA PPP3CA ENSMFAP00000034570 ENSMFAP00000034570 OVOL1 OVOL1 WHRN WHRN GLI2 GLI2 CDH23 CDH23 ERCC3 ERCC3 TPRN TPRN KRT72 KRT72 YAP1 YAP1 S100A7L2 S100A7L2 KLK5 KLK5 ANXA1 ANXA1 KDF1 KDF1 SCRIB SCRIB KRT78 KRT78 TMC1 TMC1 OPN3 OPN3 ENSMFAP00000029114 ENSMFAP00000029114 FOXN1 FOXN1 STRC STRC GSDME GSDME CLRN1 CLRN1 CASP14 CASP14 EPHA2 EPHA2 KRT73 KRT73 LIPN LIPN KRT77 KRT77 GATA6 GATA6 LIPK LIPK MYO7A MYO7A CSTA CSTA BCR BCR PTPRQ PTPRQ ENSMFAP00000025317 ENSMFAP00000025317 KRT2 KRT2 KCNQ1 KCNQ1 USH2A USH2A CERS3 CERS3 FOSL2 FOSL2 ACER1 ACER1 FGF20 FGF20 TP63 TP63 MADCAM1 MADCAM1 KLF4 KLF4 CNFN CNFN LATS2 LATS2 KRT71 KRT71 LOC102119771 LOC102119771 WDPCP WDPCP MCOLN3 MCOLN3 KAZN KAZN JAG1 JAG1 ST14 ST14 KRT7 KRT7 GLI1 GLI1 KRT86 KRT86 BCL11B BCL11B SAV1 SAV1 KRT6A KRT6A DNASE1L2 DNASE1L2 TSG101 TSG101 DLX3 DLX3 PTCH1 PTCH1 PLEC PLEC DSG4 DSG4 DSP DSP KRT74 KRT74 KRT75 KRT75 PIP5K1A PIP5K1A WNT16 WNT16 CLRN2 CLRN2 SPINK5 SPINK5 TGM1 TGM1 SCEL SCEL STK4 STK4 GRXCR2 GRXCR2 ENSMFAP00000013932 ENSMFAP00000013932 SPRR4 SPRR4 TRIOBP TRIOBP PAX6 PAX6 FA2H FA2H OVOL2 OVOL2 ENSMFAP00000011962 ENSMFAP00000011962 EXPH5 EXPH5 SFN SFN IVL IVL ATOH1 ATOH1 LOC102118953 LOC102118953 KRTAP6-1 KRTAP6-1 ENSMFAP00000010798 ENSMFAP00000010798 SPRR2G SPRR2G KRT79 KRT79 ENSMFAP00000010148 ENSMFAP00000010148 ENSMFAP00000009885 ENSMFAP00000009885 SLC4A7 SLC4A7 PPL PPL EREG EREG KRT4 KRT4 KRT76 KRT76 LIPM LIPM KRT1 KRT1 KRT3 KRT3 HDAC1 HDAC1 KRT80 KRT80 BMP4 BMP4 CTNNB1 CTNNB1 PNPLA1 PNPLA1 USH1C USH1C TMEM132E TMEM132E PPHLN1 PPHLN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP1R18Protein phosphatase 1 regulatory subunit 18. (637 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
SLITRK6SLIT and NTRK like family member 6. (841 aa)
LOC102129056Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase. (473 aa)
ENSMFAP00000002824Uncharacterized protein. (781 aa)
KRT8IF rod domain-containing protein; Belongs to the intermediate filament family. (483 aa)
KRT83Keratin 83; Belongs to the intermediate filament family. (493 aa)
PCDH15Protocadherin related 15. (1960 aa)
PALLDPalladin, cytoskeletal associated protein. (1124 aa)
IFT74Testis cDNA, clone: QtsA-18855, similar to human coiled-coil domain containing 2 (CCDC2). (600 aa)
TMEM79Transmembrane protein 79. (394 aa)
PLS1Plastin 1. (629 aa)
INTUInturned planar cell polarity protein. (942 aa)
ENSMFAP00000045924IF rod domain-containing protein; Belongs to the intermediate filament family. (547 aa)
NOTCH1Notch receptor 1. (2556 aa)
EVPLEnvoplakin. (2033 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
KRT82Keratin 82; Belongs to the intermediate filament family. (513 aa)
IRF6Interferon regulatory factor 6. (467 aa)
PITX2Homeobox protein. (325 aa)
ASAH1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] (411 aa)
KRT16Keratin 16; Belongs to the intermediate filament family. (476 aa)
EZH2Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is m [...] (751 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
PTCH2Patched 2. (1209 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
KRT81Keratin 81; Belongs to the intermediate filament family. (505 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
ENSMFAP00000040751Uncharacterized protein. (217 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (710 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1290 aa)
LOC102136364Uncharacterized protein. (291 aa)
TXNIPThioredoxin interacting protein. (391 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (394 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
SHARPINSHANK associated RH domain interactor. (381 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1277 aa)
RESTRE1 silencing transcription factor. (1095 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
OVOL3Uncharacterized protein. (214 aa)
KRT5Keratin 5; Belongs to the intermediate filament family. (593 aa)
POU4F3POU domain protein. (568 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (768 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1075 aa)
GRXCR1Glutaredoxin and cysteine rich domain containing 1. (290 aa)
KRT85Keratin 85; Belongs to the intermediate filament family. (507 aa)
PDZD7PDZ domain containing 7. (1030 aa)
LOC102128687IF rod domain-containing protein; Belongs to the intermediate filament family. (564 aa)
ENSMFAP00000036760Uncharacterized protein. (124 aa)
KRT84Keratin 84; Belongs to the intermediate filament family. (600 aa)
FLNBFilamin B. (2633 aa)
AKR1C1-2Aldo_ket_red domain-containing protein. (366 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSMFAP00000035413annotation not available (101 aa)
LHFPL5LHFPL tetraspan subfamily member 5. (272 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ENSMFAP00000034570Uncharacterized protein. (265 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
WHRNWhirlin. (907 aa)
GLI2GLI family zinc finger 2. (1561 aa)
CDH23Cadherin related 23. (3359 aa)
ERCC3General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] (786 aa)
TPRNPhostensin domain-containing protein. (431 aa)
KRT72Keratin 72; Belongs to the intermediate filament family. (511 aa)
YAP1Yes associated protein 1. (506 aa)
S100A7L2S100 calcium binding protein A7 like 2. (116 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (291 aa)
ANXA1Annexin. (346 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
SCRIBScribble planar cell polarity protein. (1662 aa)
KRT78Keratin 78; Belongs to the intermediate filament family. (514 aa)
TMC1Transmembrane channel-like protein. (761 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. (402 aa)
ENSMFAP00000029114Uncharacterized protein. (88 aa)
FOXN1Forkhead box N1. (648 aa)
STRCStereocilin. (1768 aa)
GSDMEGasdermin E. (495 aa)
CLRN1Clarin 1. (245 aa)
CASP14Caspase 14; Belongs to the peptidase C14A family. (242 aa)
EPHA2Ephrin type-A receptor 2; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin- A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DS [...] (1036 aa)
KRT73Keratin 73; Belongs to the intermediate filament family. (540 aa)
LIPNLipase; Belongs to the AB hydrolase superfamily. Lipase family. (398 aa)
KRT77Keratin 77; Belongs to the intermediate filament family. (579 aa)
GATA6GATA binding protein 6. (557 aa)
LIPKLipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
MYO7AMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2215 aa)
CSTACystatin A; Belongs to the cystatin family. (98 aa)
BCRBCR activator of RhoGEF and GTPase. (1227 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (2332 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
KRT2Keratin 2; Belongs to the intermediate filament family. (622 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (644 aa)
USH2AUsherin. (5210 aa)
CERS3Ceramide synthase 3. (385 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (686 aa)
MADCAM1Mucosal vascular addressin cell adhesion molecule 1. (361 aa)
KLF4Testis cDNA clone: QtsA-19426, similar to human Kruppel-like factor 4 (gut) (KLF4). (479 aa)
CNFNCornifelin. (125 aa)
LATS2Large tumor suppressor kinase 2. (911 aa)
KRT71Keratin 71; Belongs to the intermediate filament family. (525 aa)
LOC102119771Protein S100; Belongs to the S-100 family. (101 aa)
WDPCPWD repeat containing planar cell polarity effector. (731 aa)
MCOLN3Mucolipin 3. (553 aa)
KAZNKazrin, periplakin interacting protein. (863 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa)
KRT7Keratin 7; Belongs to the intermediate filament family. (469 aa)
GLI1GLI family zinc finger 1. (1106 aa)
KRT86Keratin 86; Belongs to the intermediate filament family. (365 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (870 aa)
SAV1Uncharacterized protein. (384 aa)
KRT6AKeratin 6A; Belongs to the intermediate filament family. (564 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (278 aa)
TSG101Tumor susceptibility 101. (390 aa)
DLX3Distal-less homeobox 3. (287 aa)
PTCH1Patched 1. (1398 aa)
PLECPlectin. (4684 aa)
DSG4Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1041 aa)
DSPDesmoplakin. (2871 aa)
KRT74Keratin 74; Belongs to the intermediate filament family. (543 aa)
KRT75Keratin 75; Belongs to the intermediate filament family. (551 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CLRN2Clarin 2. (232 aa)
SPINK5Serine peptidase inhibitor, Kazal type 5. (1087 aa)
TGM1Transglutaminase 1. (842 aa)
SCELSciellin. (718 aa)
STK4Serine/threonine kinase 4. (487 aa)
GRXCR2Glutaredoxin and cysteine rich domain containing 2. (248 aa)
ENSMFAP00000013932Uncharacterized protein. (110 aa)
SPRR4Small proline rich protein 4. (84 aa)
TRIOBPPH domain-containing protein. (591 aa)
PAX6Uncharacterized protein. (462 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (By similarity). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (By [...] (372 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
ENSMFAP00000011962Uncharacterized protein. (110 aa)
EXPH5Exophilin 5. (1990 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
IVLInvolucrin. (546 aa)
ATOH1Atonal bHLH transcription factor 1. (354 aa)
LOC102118953IF rod domain-containing protein; Belongs to the intermediate filament family. (489 aa)
KRTAP6-1Keratin associated protein 6-1. (71 aa)
ENSMFAP00000010798annotation not available (72 aa)
SPRR2GSmall proline rich protein 2G. (73 aa)
KRT79Keratin 79; Belongs to the intermediate filament family. (528 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
ENSMFAP00000009885PIPK domain-containing protein. (330 aa)
SLC4A7Anion exchange protein. (1259 aa)
PPLPeriplakin. (1735 aa)
EREGEpiregulin. (169 aa)
KRT4Keratin 4; Belongs to the intermediate filament family. (520 aa)
KRT76Keratin 76; Belongs to the intermediate filament family. (637 aa)
LIPMLipase; Belongs to the AB hydrolase superfamily. Lipase family. (423 aa)
KRT1Keratin 1; Belongs to the intermediate filament family. (636 aa)
KRT3Keratin 3; Belongs to the intermediate filament family. (614 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
KRT80Keratin 80; Belongs to the intermediate filament family. (422 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CTNNB1Catenin beta 1. (781 aa)
PNPLA1Patatin like phospholipase domain containing 1. (532 aa)
USH1CUSH1 protein network component harmonin. (899 aa)
TMEM132ETransmembrane protein 132E. (1074 aa)
PPHLN1Periphilin 1. (458 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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