STRINGSTRING
RREB1 RREB1 EMC10 EMC10 PLCG1 PLCG1 PPM1F PPM1F MAPRE2 MAPRE2 TGFB1 TGFB1 PIK3CD PIK3CD GRN GRN CALR CALR SASH1 SASH1 BCAR1 BCAR1 CCBE1 CCBE1 RAB25 RAB25 CTSH CTSH ENSMFAP00000002824 ENSMFAP00000002824 JCAD JCAD ARF6 ARF6 CLASP2 CLASP2 ATP5F1A ATP5F1A DOCK5 DOCK5 CAPN7 CAPN7 NOS3 NOS3 ETS1 ETS1 CIB1 CIB1 TGFB2 TGFB2 TDGF1 TDGF1 PIK3CB PIK3CB BMP4 BMP4 FGF2 FGF2 PLK2 PLK2 AGT AGT HDAC9 HDAC9 STAT5A STAT5A PLPP3 PLPP3 PRKCA PRKCA MET MET PTGS2 PTGS2 RRAS RRAS ZNF580 ZNF580 FUT1 FUT1 RHOB RHOB PDPK1 PDPK1 MMP9 MMP9 ATOH8 ATOH8 FGF1 FGF1 PDGFB PDGFB ITGA2 ITGA2 AKT1 AKT1 SRC SRC BMPR2 BMPR2 AMOT AMOT HIF1A HIF1A ZC3H12A ZC3H12A HAS2 HAS2 CD40 CD40 NRP1 NRP1 THBS1 THBS1 PIK3CG PIK3CG AKT3 AKT3 MAP3K3 MAP3K3 MAP4K4 MAP4K4 ADGRA2 ADGRA2 ENSMFAP00000022686 ENSMFAP00000022686 KDR KDR VIL1 VIL1 ITGA3 ITGA3 ROCK2 ROCK2 TACR1 TACR1 HBEGF HBEGF IFNG IFNG CLASP1 CLASP1 IQSEC1 IQSEC1 VEGFA VEGFA HDAC6 HDAC6 HDAC7 HDAC7 LGMN LGMN FGF16 FGF16 ENSMFAP00000026709 ENSMFAP00000026709 WNT7A WNT7A TEK TEK TSTA3 TSTA3 SRPX2 SRPX2 SP1 SP1 HSPB1 HSPB1 GPLD1 GPLD1 ITGB1BP1 ITGB1BP1 ANGPT1 ANGPT1 ANGPT4 ANGPT4 FGF7 FGF7 BCAS3 BCAS3 PROX1 PROX1 ENSMFAP00000030346 ENSMFAP00000030346 ANXA1 ANXA1 IRS2 IRS2 PLCG2 PLCG2 GATA3 GATA3 NUS1 NUS1 ENPP2 ENPP2 RIN2 RIN2 HYAL1 HYAL1 RTN4 RTN4 ANXA3 ANXA3 PRKCE PRKCE FGF10 FGF10 EGF EGF VEGFC VEGFC PTK2B PTK2B SMOC2 SMOC2 TGFBR2 TGFBR2 ENSMFAP00000035291 ENSMFAP00000035291 ATP5F1B ATP5F1B FOXC2 FOXC2 WNT5A WNT5A GLIPR2 GLIPR2 AAMP AAMP FGFR1 FGFR1 MAP2K3 MAP2K3 FGF18 FGF18 GATA2 GATA2 SPARC SPARC SEMA5A SEMA5A PRKD2 PRKD2 DOCK1 DOCK1 SIRT1 SIRT1 NFE2L2 NFE2L2 P2RX4 P2RX4 RHOJ RHOJ EPB41L4B EPB41L4B CCR6 CCR6 ITGB3 ITGB3 MTOR MTOR PRKD1 PRKD1 BSG BSG FOXP1 FOXP1 ADAM17 ADAM17 NRP2 NRP2 ALOX12 ALOX12 ADAM9 ADAM9 SOX9 SOX9 HMOX1 HMOX1 FLT4 FLT4 ABL1 ABL1 SCARB1 SCARB1 EPB41L5 EPB41L5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RREB1Ras responsive element binding protein 1. (1744 aa)
EMC10ER membrane protein complex subunit 10. (335 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (455 aa)
MAPRE2Microtubule associated protein RP/EB family member 2. (327 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRNUncharacterized protein. (593 aa)
CALRCalreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. (417 aa)
SASH1SAM and SH3 domain containing 1. (1246 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
RAB25RAB25, member RAS oncogene family. (213 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
ENSMFAP00000002824Uncharacterized protein. (781 aa)
JCADJunctional cadherin 5 associated. (1356 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa)
CLASP2Uncharacterized protein. (1514 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (584 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1870 aa)
CAPN7Calpain 7; Belongs to the peptidase C2 family. (748 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
CIB1Calcium and integrin binding 1. (231 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (182 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
AGTSERPIN domain-containing protein; Belongs to the serpin family. (485 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
PLPP3acidPPc domain-containing protein. (353 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
RRASRAS related. (218 aa)
ZNF580Zinc finger protein 580. (172 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (366 aa)
RHOBRas homolog gene family, member B. (196 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (510 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
ATOH8Atonal bHLH transcription factor 8. (321 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SRCTyrosine-protein kinase. (542 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
AMOTAngiomotin. (1099 aa)
HIF1AUncharacterized protein. (831 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
HAS2Hyaluronan synthase 2. (552 aa)
CD40CD40 molecule. (278 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
THBS1Thrombospondin 1. (1173 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1351 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1340 aa)
ENSMFAP00000022686Uncharacterized protein. (440 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
VIL1Villin 1. (830 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
CLASP1Cytoplasmic linker associated protein 1. (1533 aa)
IQSEC1IQ motif and Sec7 domain 1. (1115 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (409 aa)
HDAC6Histone deacetylase 6. (1215 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1008 aa)
LGMNLegumain; Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). (433 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ENSMFAP00000026709CFC domain-containing protein. (170 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
TSTA3Tissue specific transplantation antigen P35B. (321 aa)
SRPX2Sushi repeat containing protein X-linked 2. (465 aa)
SP1Sp1 transcription factor. (786 aa)
HSPB1SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (841 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
ANGPT1Angiopoietin 1. (498 aa)
ANGPT4Angiopoietin 4. (503 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (922 aa)
PROX1Prospero homeobox 1. (737 aa)
ENSMFAP00000030346ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (411 aa)
ANXA1Annexin. (346 aa)
IRS2Insulin receptor substrate 2. (1279 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
GATA3GATA binding protein 3. (444 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (915 aa)
RIN2Ras and Rab interactor 2. (895 aa)
HYAL1Hyaluronidase. (435 aa)
RTN4Reticulon. (1193 aa)
ANXA3Annexin. (323 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
SMOC2SPARC related modular calcium binding 2. (330 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ENSMFAP00000035291Uncharacterized protein. (159 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
FOXC2Forkhead box C2. (487 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
GLIPR2Testis cDNA clone: QtsA-11864, similar to human chromosome 9 open reading frame 19 (C9orf19); Belongs to the CRISP family. (165 aa)
AAMPAngio associated migratory cell protein. (454 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GATA2GATA binding protein 2. (480 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
SEMA5ASemaphorin 5A. (1074 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
SIRT1Sirtuin 1. (743 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
RHOJUncharacterized protein. (214 aa)
EPB41L4BErythrocyte membrane protein band 4.1 like 4B. (831 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (379 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
BSGBasigin (Ok blood group). (366 aa)
FOXP1Forkhead box P1. (693 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
SOX9SRY-box transcription factor 9. (509 aa)
HMOX1Uncharacterized protein. (288 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase. (901 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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