STRINGSTRING
BBC3 BBC3 PRKN PRKN ENSMFAP00000005736 ENSMFAP00000005736 VDAC1 VDAC1 GSK3B GSK3B CHCHD10 CHCHD10 ENSMFAP00000008168 ENSMFAP00000008168 SIVA1 SIVA1 DNM1L DNM1L PINK1 PINK1 BAK1 BAK1 ENSMFAP00000014116 ENSMFAP00000014116 RALBP1 RALBP1 MMP9 MMP9 ZNF205 ZNF205 FAM162A FAM162A TREM2 TREM2 ENSMFAP00000017863 ENSMFAP00000017863 HIF1A HIF1A DDHD2 DDHD2 SLC25A4 SLC25A4 SSBP1 SSBP1 ENSMFAP00000019793 ENSMFAP00000019793 CIDEB CIDEB PYCARD PYCARD BAX BAX HTRA2 HTRA2 MCU MCU ENSMFAP00000022286 ENSMFAP00000022286 BAD BAD GZMB GZMB KDR KDR PLD6 PLD6 MGARP MGARP BMF BMF ENSMFAP00000026182 ENSMFAP00000026182 VPS13D VPS13D BID BID CAMKK2 CAMKK2 ENSMFAP00000028396 ENSMFAP00000028396 ZDHHC6 ZDHHC6 BIK BIK ENSMFAP00000029116 ENSMFAP00000029116 PARK7 PARK7 HTT HTT BNIP3 BNIP3 ENSMFAP00000031774 ENSMFAP00000031774 FBXO7 FBXO7 PGAM5 PGAM5 ADCK1 ADCK1 MUL1 MUL1 ATP5IF1 ATP5IF1 DCN DCN MAPK8 MAPK8 TP53 TP53 GSK3A GSK3A FIS1 FIS1 PLA2G6 PLA2G6 HIP1R HIP1R PPIF PPIF MARCHF5 MARCHF5 VPS35 VPS35 GPER1 GPER1 MIEF2 MIEF2 ENSMFAP00000042703 ENSMFAP00000042703 BCL2L11 BCL2L11 STOML2 STOML2 MIEF1 MIEF1 MFF MFF BOK BOK PPARGC1A PPARGC1A MOAP1 MOAP1 DDHD1 DDHD1 ENSMFAP00000002951 ENSMFAP00000002951 ENSMFAP00000003190 ENSMFAP00000003190 MAPK10 MAPK10 RALA RALA SPIRE1 SPIRE1 AURKA AURKA AMBRA1 AMBRA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BBC3BCL2 binding component 3. (261 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
ENSMFAP00000005736Protein kinase domain-containing protein. (334 aa)
VDAC1Uncharacterized protein. (289 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
CHCHD10Coiled-coil-helix-coiled-coil-helix domain containing 10. (142 aa)
ENSMFAP00000008168Uncharacterized protein. (511 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
DNM1LUncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa)
PINK1Protein kinase domain-containing protein. (581 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ENSMFAP00000014116Rho-GAP domain-containing protein. (550 aa)
RALBP1RalA binding protein 1. (655 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
ZNF205Zinc finger protein 205. (555 aa)
FAM162AFamily with sequence similarity 162 member A. (155 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
ENSMFAP00000017863Uncharacterized protein. (235 aa)
HIF1AUncharacterized protein. (831 aa)
DDHD2DDHD domain containing 2. (630 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
ENSMFAP00000019793DJ-1_PfpI domain-containing protein. (134 aa)
CIDEBCell death inducing DFFA like effector b. (220 aa)
PYCARDPYD and CARD domain containing. (195 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
MCUMitochondrial calcium uniporter. (351 aa)
ENSMFAP00000022286Uncharacterized protein. (156 aa)
BADBCL2 associated agonist of cell death. (167 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (281 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PLD6Phospholipase D family member 6. (224 aa)
MGARPMitochondria localized glutamic acid rich protein. (240 aa)
BMFBcl2 modifying factor. (184 aa)
ENSMFAP00000026182Uncharacterized protein. (183 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4271 aa)
BIDBH3 interacting domain death agonist. (244 aa)
CAMKK2Protein kinase domain-containing protein. (582 aa)
ENSMFAP00000028396DJ-1_PfpI domain-containing protein. (166 aa)
ZDHHC6Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (413 aa)
BIKBCL2 interacting killer. (160 aa)
ENSMFAP00000029116Uncharacterized protein. (246 aa)
PARK7DJ-1_PfpI domain-containing protein. (189 aa)
HTTHuntingtin. (3118 aa)
BNIP3BCL2 interacting protein 3. (248 aa)
ENSMFAP00000031774DJ-1_PfpI domain-containing protein. (133 aa)
FBXO7F-box protein 7. (522 aa)
PGAM5Uncharacterized protein. (140 aa)
ADCK1AarF domain containing kinase 1. (523 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1; Exhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targete [...] (352 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (106 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
HIP1RHuntingtin interacting protein 1 related. (1068 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
MARCHF5Membrane associated ring-CH-type finger 5. (278 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
MIEF2Mitochondrial elongation factor 2. (465 aa)
ENSMFAP00000042703Rho-GAP domain-containing protein. (543 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
STOML2Stomatin like 2. (361 aa)
MIEF1Mitochondrial elongation factor 1. (478 aa)
MFFMitochondrial fission factor. (341 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
MOAP1Modulator of apoptosis 1; Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (By similarity); Belongs to the PNMA family. (351 aa)
DDHD1DDHD domain containing 1. (906 aa)
ENSMFAP00000002951Miff domain-containing protein. (78 aa)
ENSMFAP00000003190Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (280 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
RALARAS like proto-oncogene A. (206 aa)
SPIRE1Protein spire homolog 1; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in [...] (757 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (403 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: medium (60%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.