STRINGSTRING
SPATA2 SPATA2 TSPO TSPO SLC6A13 SLC6A13 CASP6 CASP6 DDR2 DDR2 OGT OGT ATG9B ATG9B ARHGEF2 ARHGEF2 FZD9 FZD9 MUTYH MUTYH NUPR1 NUPR1 MT3 MT3 ZBP1 ZBP1 SLC25A4 SLC25A4 BIRC2 BIRC2 PELI1 PELI1 BIRC3 BIRC3 NOL3 NOL3 FADD FADD RBCK1 RBCK1 CASP2 CASP2 BNIP3 BNIP3 RIPK1 RIPK1 ATG9A ATG9A ADPRHL2 ADPRHL2 RIPK3 RIPK3 CASP8 CASP8 SLC6A6 SLC6A6 TP53 TP53 CAV1 CAV1 HEBP2 HEBP2 PPIF PPIF RNF31 RNF31 YBX3 YBX3 ASAH1 ASAH1 BOK BOK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPATA2Spermatogenesis associated 2. (520 aa)
TSPOTranslocator protein. (169 aa)
SLC6A13Sodium- and chloride-dependent GABA transporter 2; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport (By similarity). Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily. (609 aa)
CASP6Uncharacterized protein; Belongs to the peptidase C14A family. (293 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (873 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (922 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (550 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (100 aa)
MT3Metallothionein-3; Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium (By similarity). (113 aa)
ZBP1Z-DNA binding protein 1. (420 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
NOL3CARD domain-containing protein. (258 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
BNIP3BCL2 interacting protein 3. (248 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (851 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (364 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa)
SLC6A6Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (649 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
HEBP2Heme binding protein 2. (205 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
RNF31Uncharacterized protein. (1072 aa)
YBX3Y-box binding protein 3. (372 aa)
ASAH1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] (411 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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