STRINGSTRING
TBX15 TBX15 ENSMFAP00000025816 ENSMFAP00000025816 SP1 SP1 SPEN SPEN HOXC9 HOXC9 LOC102115909 LOC102115909 DR1 DR1 ARID4A ARID4A CBX5 CBX5 ENSMFAP00000034570 ENSMFAP00000034570 DEPDC1 DEPDC1 LIN52 LIN52 NCOR1 NCOR1 JAZF1 JAZF1 RCOR1 RCOR1 ENSMFAP00000025317 ENSMFAP00000025317 HDGF HDGF TP53 TP53 REST REST CTBP2 CTBP2 PASD1 PASD1 ELANE ELANE TBX18 TBX18 MYC MYC DRAP1 DRAP1 ZNF350 ZNF350 ENSMFAP00000043974 ENSMFAP00000043974 MIER1 MIER1 MXD1 MXD1 CDX2 CDX2 ZNF224 ZNF224 GPS2 GPS2 HDAC4 HDAC4 ENSMFAP00000019629 ENSMFAP00000019629 RELB RELB SKI SKI RBBP8 RBBP8 HEY2 HEY2 BIN1 BIN1 GATA1 GATA1 GMNN GMNN DDX20 DDX20 GLI3 GLI3 LIN54 LIN54 CTNNBIP1 CTNNBIP1 ENSMFAP00000014153 ENSMFAP00000014153 LOC102127640 LOC102127640 CORO2A CORO2A ENSMFAP00000012453 ENSMFAP00000012453 AKIRIN2 AKIRIN2 ENSMFAP00000012353 ENSMFAP00000012353 LIN37 LIN37 INSM2 INSM2 ZBTB16 ZBTB16 N4BP2L2 N4BP2L2 TBL1XR1 TBL1XR1 TBL1X TBL1X ENSMFAP00000010148 ENSMFAP00000010148 HDAC1 HDAC1 LIN9 LIN9 SP3 SP3 CTNNB1 CTNNB1 GFI1 GFI1 CTBP1 CTBP1 PHF12 PHF12 SIN3A SIN3A TFAP4 TFAP4 MEN1 MEN1 HDAC3 HDAC3 NCOR2 NCOR2 SDR16C5 SDR16C5 RLIM RLIM MAX MAX INSM1 INSM1 PRDM16 PRDM16 JUND JUND MDM4 MDM4 CCND1 CCND1 ZFPM1 ZFPM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBX15T-box transcription factor 15. (602 aa)
ENSMFAP00000025816RING-type domain-containing protein. (500 aa)
SP1Sp1 transcription factor. (786 aa)
SPENSpen family transcriptional repressor. (3672 aa)
HOXC9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
LOC102115909RelB_leu_zip domain-containing protein. (80 aa)
DR1Down-regulator of transcription 1. (176 aa)
ARID4AAT-rich interaction domain 4A. (1257 aa)
CBX5Chromobox 5. (191 aa)
ENSMFAP00000034570Uncharacterized protein. (265 aa)
DEPDC1DEP domain containing 1. (812 aa)
LIN52Lin-52 DREAM MuvB core complex component. (116 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
JAZF1JAZF zinc finger 1. (219 aa)
RCOR1REST corepressor 1. (409 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
HDGFHeparin binding growth factor. (256 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa)
RESTRE1 silencing transcription factor. (1095 aa)
CTBP2C-terminal binding protein 2. (985 aa)
PASD1PAS domain containing repressor 1. (758 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (264 aa)
TBX18T-box transcription factor 18. (607 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
DRAP1DR1 associated protein 1. (205 aa)
ZNF350Zinc finger protein 350. (533 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
MIER1MIER1 transcriptional regulator. (565 aa)
MXD1MAX dimerization protein 1. (221 aa)
CDX2Caudal type homeobox 2. (313 aa)
ZNF224Zinc finger protein 224. (707 aa)
GPS2G protein pathway suppressor 2. (327 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa)
ENSMFAP00000019629Uncharacterized protein. (331 aa)
RELBRELB proto-oncogene, NF-kB subunit. (526 aa)
SKISKI proto-oncogene. (681 aa)
RBBP8RB binding protein 8, endonuclease. (898 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
BIN1Bridging integrator 1. (451 aa)
GATA1GATA binding protein 1. (413 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
DDX20DEAD-box helicase 20. (856 aa)
GLI3GLI family zinc finger 3. (1579 aa)
LIN54Lin-54 DREAM MuvB core complex component. (749 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
ENSMFAP00000014153Uncharacterized protein. (518 aa)
LOC102127640Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (437 aa)
CORO2ACoronin; Belongs to the WD repeat coronin family. (525 aa)
ENSMFAP00000012453Hist_deacetyl domain-containing protein. (223 aa)
AKIRIN2Akirin 2. (205 aa)
ENSMFAP00000012353Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (435 aa)
LIN37Lin-37 DREAM MuvB core complex component. (246 aa)
INSM2INSM transcriptional repressor 2. (568 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
N4BP2L2NEDD4 binding protein 2 like 2. (747 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (543 aa)
TBL1XF-box-like/WD repeat-containing protein TBL1X; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. (569 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
LIN9Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition (By similarity). (613 aa)
SP3Sp3 transcription factor. (756 aa)
CTNNB1Catenin beta 1. (781 aa)
GFI1Growth factor independent 1 transcriptional repressor. (422 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (438 aa)
PHF12PHD finger protein 12. (1004 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
TFAP4Transcription factor AP-4. (299 aa)
MEN1Menin 1. (615 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
NCOR2Nuclear receptor corepressor 2. (2510 aa)
SDR16C5Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
RLIMRing finger protein, LIM domain interacting. (624 aa)
MAXBHLH domain-containing protein. (160 aa)
INSM1INSM transcriptional repressor 1. (504 aa)
PRDM16PR/SET domain 16. (1276 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (325 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (478 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ZFPM1Zinc finger protein, FOG family member 1. (878 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: low (18%) [HD]