STRINGSTRING
PRKD2 PRKD2 MAPK8 MAPK8 TTBK1 TTBK1 LMTK2 LMTK2 PKN1 PKN1 WNK1 WNK1 TGFBR2 TGFBR2 ROCK1 ROCK1 CDK1 CDK1 DCAF1 DCAF1 PRKCD PRKCD CSNK2A2 CSNK2A2 MYLK2 MYLK2 ROCK2 ROCK2 STK11 STK11 MAP3K12 MAP3K12 CDC42BPB CDC42BPB MAP3K10 MAP3K10 TGFBR1 TGFBR1 UMOD UMOD NLK NLK HIPK3 HIPK3 ULK1 ULK1 ACVR1 ACVR1 DYRK4 DYRK4 CSNK2A1 CSNK2A1 LRRK2 LRRK2 CAD CAD HIPK2 HIPK2 MAPK10 MAPK10 TAF1 TAF1 MAPK1 MAPK1 CDK5 CDK5 GRK2 GRK2 ATF2 ATF2 GSK3B GSK3B CIT CIT OXSR1 OXSR1 CAMK2D CAMK2D CDC42BPA CDC42BPA HIPK1 HIPK1 CHEK1 CHEK1 VRK1 VRK1 BCL2 BCL2 CDK5R1 CDK5R1 LOC102142638 LOC102142638 PRKCA PRKCA TNKS TNKS CLK1 CLK1 PDPK1 PDPK1 PRKCB PRKCB WNK3 WNK3 AKT1 AKT1 TBK1 TBK1 STK39 STK39 ACVR1B ACVR1B DYRK2 DYRK2 MARK2 MARK2 SBK1 SBK1 PRKDC PRKDC DYRK1A DYRK1A TSSK4 TSSK4 CAMK2A CAMK2A GSK3A GSK3A MTOR MTOR PRKD1 PRKD1 DYRK1B DYRK1B CDK10 CDK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TTBK1Tau tubulin kinase 1. (1324 aa)
LMTK2Lemur tyrosine kinase 2. (1461 aa)
PKN1Protein kinase N1. (949 aa)
WNK1WNK lysine deficient protein kinase 1. (2835 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1493 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
MYLK2Myosin light chain kinase 2. (511 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (890 aa)
CDC42BPBCDC42 binding protein kinase beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1711 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (883 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
UMODUromodulin. (641 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
HIPK3Homeodomain interacting protein kinase 3. (1215 aa)
ULK1Unc-51 like autophagy activating kinase 1. (967 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
DYRK4Dual specificity tyrosine phosphorylation regulated kinase 4. (636 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
CADCarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2225 aa)
HIPK2Homeodomain interacting protein kinase 2. (1196 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
TAF1Transcription initiation factor TFIID subunit. (1927 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (674 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2069 aa)
OXSR1Oxidative stress responsive kinase 1. (527 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
CDC42BPANon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1732 aa)
HIPK1Homeodomain interacting protein kinase 1. (1210 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (488 aa)
VRK1VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily. (396 aa)
BCL2BCL2 apoptosis regulator. (242 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
LOC102142638Protein kinase domain-containing protein. (297 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
CLK1Protein kinase domain-containing protein. (526 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (510 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
WNK3WNK lysine deficient protein kinase 3. (1797 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TBK1TANK binding kinase 1. (729 aa)
STK39Serine/threonine kinase 39. (548 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (606 aa)
MARK2Non-specific serine/threonine protein kinase. (774 aa)
SBK1Serine/threonine-protein kinase SBK1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (372 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (754 aa)
TSSK4Testis specific serine kinase 4. (338 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (629 aa)
CDK10Cyclin dependent kinase 10; Belongs to the protein kinase superfamily. (361 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.