STRINGSTRING
MOGAT3 MOGAT3 ITPK1 ITPK1 ENSMFAP00000001213 ENSMFAP00000001213 SPTLC2 SPTLC2 GK GK MTMR2 MTMR2 CYP27A1 CYP27A1 IPMK IPMK IP6K3 IP6K3 SYNJ2 SYNJ2 IP6K1 IP6K1 GK5 GK5 CYP27B1 CYP27B1 ITPKC ITPKC CYP2R1 CYP2R1 INPP5E INPP5E ENSMFAP00000006752 ENSMFAP00000006752 MINPP1 MINPP1 SPTSSA SPTSSA NUDT11 NUDT11 ABCA2 ABCA2 PCBD1 PCBD1 TMEM130 TMEM130 ENSMFAP00000008017 ENSMFAP00000008017 SPHK2 SPHK2 MOGAT1 MOGAT1 PPIP5K1 PPIP5K1 MTMR7 MTMR7 ANGPTL3 ANGPTL3 GK2 GK2 GALK1 GALK1 SLC5A3 SLC5A3 SYNJ1 SYNJ1 PLPP3 PLPP3 SPTLC1 SPTLC1 GOT1 GOT1 SPTSSB SPTSSB PTAFR PTAFR INPP5K INPP5K NTSR1 NTSR1 IMPA2 IMPA2 PLPP1 PLPP1 ENSMFAP00000015159 ENSMFAP00000015159 IMPA1 IMPA1 SLC34A1 SLC34A1 IP6K2 IP6K2 GPD2 GPD2 SHPK SHPK LOC102129084 LOC102129084 PPIP5K2 PPIP5K2 SGPP2 SGPP2 MOGAT2 MOGAT2 SPHK1 SPHK1 TKFC TKFC INPP5J INPP5J MIOX MIOX MECP2 MECP2 INPP4A INPP4A COQ2 COQ2 PTS PTS OCRL OCRL NUDT4 NUDT4 ITPKB ITPKB ENSMFAP00000022236 ENSMFAP00000022236 DGAT2 DGAT2 ACER1 ACER1 PLCB1 PLCB1 DEGS2 DEGS2 PCK1 PCK1 PLA2G4A PLA2G4A NUDT10 NUDT10 PCBD2 PCBD2 ISYNA1 ISYNA1 PLPP2 PLPP2 SPTLC3 SPTLC3 PGP PGP LRP2 LRP2 NAAA NAAA SGPP1 SGPP1 PLCG2 PLCG2 NUDT3 NUDT3 PCK2 PCK2 PTEN PTEN IPPK IPPK INPP5A INPP5A ACER2 ACER2 BPNT1 BPNT1 ASAH2 ASAH2 IMPAD1 IMPAD1 COQ3 COQ3 INPP5B INPP5B PRKG2 PRKG2 ENSMFAP00000039470 ENSMFAP00000039470 CYP3A4 CYP3A4 ENSMFAP00000039904 ENSMFAP00000039904 ACER3 ACER3 GALR2 GALR2 SPR SPR QDPR QDPR ITPKA ITPKA SCP2 SCP2 PSORS1C2 PSORS1C2 ASAH1 ASAH1 GCH1 GCH1 INPP1 INPP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MOGAT3Monoacylglycerol O-acyltransferase 3. (341 aa)
ITPK1Inositol-tetrakisphosphate 1-kinase. (414 aa)
ENSMFAP00000001213Uncharacterized protein. (198 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (555 aa)
GKUncharacterized protein; Belongs to the FGGY kinase family. (564 aa)
MTMR2Myotubularin related protein 2. (643 aa)
CYP27A1Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (534 aa)
IPMKKinase; Belongs to the inositol phosphokinase (IPK) family. (416 aa)
IP6K3Kinase; Belongs to the inositol phosphokinase (IPK) family. (410 aa)
SYNJ2Synaptojanin 2. (1390 aa)
IP6K1Kinase; Belongs to the inositol phosphokinase (IPK) family. (441 aa)
GK5Glycerol kinase 5; Belongs to the FGGY kinase family. (529 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (556 aa)
CYP2R1Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (501 aa)
INPP5EInositol polyphosphate-5-phosphatase E. (644 aa)
ENSMFAP00000006752INPP5B_PH domain-containing protein. (224 aa)
MINPP1Multiple inositol-polyphosphate phosphatase 1; Belongs to the histidine acid phosphatase family. (487 aa)
SPTSSASerine palmitoyltransferase small subunit A. (71 aa)
NUDT11Nudix hydrolase 11. (165 aa)
ABCA2ATP binding cassette subfamily A member 2. (2469 aa)
PCBD1Pterin-4 alpha-carbinolamine dehydratase 1. (104 aa)
TMEM130Transmembrane protein 130. (352 aa)
ENSMFAP00000008017Uncharacterized protein. (105 aa)
SPHK2Sphingosine kinase 2. (653 aa)
MOGAT1Monoacylglycerol O-acyltransferase 1. (335 aa)
PPIP5K1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1416 aa)
MTMR7Myotubularin related protein 7. (662 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
GK2Glycerol kinase 2; Key enzyme in the regulation of glycerol uptake and metabolism; Belongs to the FGGY kinase family. (553 aa)
GALK1Galactokinase 1. (422 aa)
SLC5A3Solute carrier family 5 member 3; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (718 aa)
SYNJ1Synaptojanin 1. (1548 aa)
PLPP3acidPPc domain-containing protein. (353 aa)
SPTLC1Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] (500 aa)
GOT1Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (413 aa)
SPTSSBSerine palmitoyltransferase small subunit B. (76 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (450 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
IMPA2Inositol-1-monophosphatase. (288 aa)
PLPP1Phospholipid phosphatase 1. (285 aa)
ENSMFAP00000015159FGGY_N domain-containing protein. (130 aa)
IMPA1Inositol-1-monophosphatase. (309 aa)
SLC34A1Solute carrier family 34 member 1. (680 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (478 aa)
GPD2Glycerol-3-phosphate dehydrogenase, mitochondrial. (727 aa)
SHPKFGGY_N domain-containing protein. (479 aa)
LOC102129084Uncharacterized protein. (399 aa)
PPIP5K2Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1278 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (399 aa)
MOGAT2Monoacylglycerol O-acyltransferase 2. (334 aa)
SPHK1Sphingosine kinase 1. (470 aa)
TKFCTriokinase and FMN cyclase. (575 aa)
INPP5JInositol polyphosphate-5-phosphatase J. (1001 aa)
MIOXMyo-inositol oxygenase. (285 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
INPP4AInositol polyphosphate-4-phosphatase type I A. (977 aa)
COQ24-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (420 aa)
PTS6-pyruvoyl tetrahydrobiopterin synthase. (145 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (901 aa)
NUDT4Nudix hydrolase domain-containing protein. (181 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (941 aa)
ENSMFAP00000022236Uncharacterized protein. (85 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (323 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PLA2G4APhospholipase A2. (749 aa)
NUDT10Nudix hydrolase 10. (166 aa)
PCBD2Pterin-4 alpha-carbinolamine dehydratase 2. (130 aa)
ISYNA1Inositol-3-phosphate synthase 1; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1- phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). (559 aa)
PLPP2Phospholipid phosphatase 2. (302 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (552 aa)
PGPPhosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (322 aa)
LRP2LDL receptor related protein 2. (4655 aa)
NAAAN-acylethanolamine acid amidase; Belongs to the acid ceramidase family. (363 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (441 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
NUDT3Nudix hydrolase 3. (172 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
IPPKInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (491 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (412 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
BPNT13'(2'), 5'-bisphosphate nucleotidase 1. (308 aa)
ASAH2Neutral ceramidase. (780 aa)
IMPAD1Inositol monophosphatase domain containing 1. (313 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (368 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (829 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
ENSMFAP00000039470EF-hand domain-containing protein. (622 aa)
CYP3A4Cytochrome P450 3A8; Catalyzes nifedipine and nilvadipine oxidations. (503 aa)
ENSMFAP00000039904Uncharacterized protein. (81 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)
GALR2Galanin receptor 2; Belongs to the G-protein coupled receptor 1 family. (387 aa)
SPRSepiapterin reductase. (261 aa)
QDPRUncharacterized protein. (280 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (461 aa)
SCP2Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
PSORS1C2Psoriasis susceptibility 1 candidate 2. (136 aa)
ASAH1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] (411 aa)
GCH1GTP cyclohydrolase 1. (250 aa)
INPP1Uncharacterized protein. (379 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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