STRINGSTRING
CASQ1 CASQ1 NEBL NEBL SYNPO SYNPO JPH2 JPH2 MYO18B MYO18B RTN2 RTN2 PDLIM3 PDLIM3 ENSMFAP00000006504 ENSMFAP00000006504 ENSMFAP00000006611 ENSMFAP00000006611 TTN TTN CTNNB1 CTNNB1 MYH7 MYH7 PDE4B PDE4B NEB NEB GLRX3 GLRX3 CFL2 CFL2 ENSMFAP00000008304 ENSMFAP00000008304 NRAP NRAP MYOT MYOT XIRP2 XIRP2 FHL3 FHL3 SMN1 SMN1 ENSMFAP00000011498 ENSMFAP00000011498 ATP2B4 ATP2B4 PDLIM4 PDLIM4 SCN8A SCN8A CSRP3 CSRP3 CAPN3 CAPN3 FBP2 FBP2 KCNA5 KCNA5 LDB3 LDB3 ENSMFAP00000013730 ENSMFAP00000013730 PDLIM1 PDLIM1 PDLIM5 PDLIM5 HRC HRC ADRA1A ADRA1A FRG1 FRG1 SCN1A SCN1A SMN1-2 SMN1-2 OBSCN OBSCN TRIM63 TRIM63 SLC2A1 SLC2A1 BIN1 BIN1 PLEC PLEC ANK2 ANK2 PPP3CB PPP3CB C3H7orf57 C3H7orf57 GGPS1 GGPS1 POLR2M POLR2M CHORDC1 CHORDC1 MYOZ3 MYOZ3 BAG3 BAG3 FLNA FLNA ANK3 ANK3 STK11 STK11 ACTN3 ACTN3 CAVIN4 CAVIN4 SYNPO2L SYNPO2L PGM5 PGM5 DMD DMD HSPB1 HSPB1 IGFN1 IGFN1 ACTN2 ACTN2 FHOD3 FHOD3 ASB2 ASB2 STUB1 STUB1 SYNC SYNC ENSMFAP00000031019 ENSMFAP00000031019 DNAJB6 DNAJB6 MYL12A MYL12A FKBP1B FKBP1B PAK1 PAK1 KRT19 KRT19 ACTN1 ACTN1 ENSMFAP00000034373 ENSMFAP00000034373 PPP1R12B PPP1R12B PPP3CA PPP3CA SORBS2 SORBS2 RYR3 RYR3 NOS1AP NOS1AP PARVB PARVB JUP JUP PRICKLE4 PRICKLE4 OBSL1 OBSL1 FLNB FLNB PPP1R12A PPP1R12A PPP2R5A PPP2R5A KCNN2 KCNN2 SYNPO2 SYNPO2 ENSMFAP00000037050 ENSMFAP00000037050 ENSMFAP00000037380 ENSMFAP00000037380 ITGB1BP2 ITGB1BP2 TRIM54 TRIM54 FHL2 FHL2 SLC8A1 SLC8A1 C10orf113 C10orf113 BMP10 BMP10 CAV3 CAV3 MYOZ1 MYOZ1 SYNE2 SYNE2 DST DST SCN5A SCN5A KY KY RYR1 RYR1 FBXO32 FBXO32 SPEGNB SPEGNB PDLIM7 PDLIM7 CACNA1D CACNA1D MYOZ2 MYOZ2 FBXO22 FBXO22 IGSF22 IGSF22 CAB39 CAB39 MYH6 MYH6 JPH1 JPH1 FBXL22 FBXL22 CACNA1C CACNA1C DES DES PARVA PARVA CSRP2 CSRP2 ENSMFAP00000000909 ENSMFAP00000000909 UNC45B UNC45B SLC4A1 SLC4A1 ENSMFAP00000045970 ENSMFAP00000045970 FLNC FLNC TCAP TCAP NEXN NEXN SRI SRI PALLD PALLD MYPN MYPN RYR2 RYR2 AKAP4 AKAP4 HOMER1 HOMER1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (398 aa)
NEBLNebulette. (1014 aa)
SYNPOSynaptopodin. (929 aa)
JPH2Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (696 aa)
MYO18BMyosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2565 aa)
RTN2Reticulon. (545 aa)
PDLIM3PDZ and LIM domain 3. (364 aa)
ENSMFAP00000006504PDZ domain-containing protein. (285 aa)
ENSMFAP00000006611Uncharacterized protein. (232 aa)
TTNTitin. (32000 aa)
CTNNB1Catenin beta 1. (781 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
PDE4BPhosphodiesterase. (736 aa)
NEBNebulin. (7588 aa)
GLRX3Glutaredoxin 3. (335 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ENSMFAP00000008304Uncharacterized protein. (303 aa)
NRAPNebulin related anchoring protein. (1731 aa)
MYOTMyotilin. (498 aa)
XIRP2Xin actin binding repeat containing 2. (3550 aa)
FHL3Uncharacterized protein. (280 aa)
SMN1Survival motor neuron protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the ch [...] (294 aa)
ENSMFAP00000011498Glutaredoxin domain-containing protein. (170 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
PDLIM4PDZ and LIM domain 4. (329 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1980 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
CAPN3Calpain-3; Calcium-regulated non-lysosomal thiol-protease. (821 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (300 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
LDB3LIM domain binding 3. (732 aa)
ENSMFAP00000013730EFhand_Ca_insen domain-containing protein. (97 aa)
PDLIM1PDZ and LIM domain 1. (330 aa)
PDLIM5PDZ and LIM domain 5. (625 aa)
HRCHistidine rich calcium binding protein. (706 aa)
ADRA1AAdrenoceptor alpha 1A. (462 aa)
FRG1FSHD region gene 1. (258 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
SMN1-2Tudor domain-containing protein. (320 aa)
OBSCNObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF. (8221 aa)
TRIM63Tripartite motif containing 63. (383 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
BIN1Bridging integrator 1. (451 aa)
PLECPlectin. (4684 aa)
ANK2Ankyrin 2. (3938 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
C3H7orf57Uncharacterized protein. (323 aa)
GGPS1Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (300 aa)
POLR2MGRINL1A complex locus 1. (773 aa)
CHORDC1Cysteine and histidine-rich domain-containing protein 1; Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis (By similarity). (333 aa)
MYOZ3Myozenin 3. (251 aa)
BAG3BCL2 associated athanogene 3. (575 aa)
FLNAFilamin A. (2651 aa)
ANK3Ankyrin 3. (4376 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (942 aa)
CAVIN4Caveolae associated protein 4. (362 aa)
SYNPO2LSynaptopodin 2 like. (979 aa)
PGM5Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (567 aa)
DMDDystrophin. (3685 aa)
HSPB1SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
IGFN1Immunoglobulin like and fibronectin type III domain containing 1. (3235 aa)
ACTN2Actinin alpha 2. (894 aa)
FHOD3Formin homology 2 domain containing 3. (1620 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (637 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
SYNCSyncoilin, intermediate filament protein; Belongs to the intermediate filament family. (481 aa)
ENSMFAP00000031019Uncharacterized protein. (98 aa)
DNAJB6DnaJ homolog subfamily B member 6; Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose- dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). (334 aa)
MYL12AMyosin light chain 12A. (177 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (400 aa)
ACTN1Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (914 aa)
ENSMFAP00000034373Uncharacterized protein. (201 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (1045 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
SORBS2Sorbin and SH3 domain containing 2. (1199 aa)
RYR3Ryanodine receptor 3. (4873 aa)
NOS1APNitric oxide synthase 1 adaptor protein. (421 aa)
PARVBParvin beta. (393 aa)
JUPJunction plakoglobin. (745 aa)
PRICKLE4Uncharacterized protein. (385 aa)
OBSL1Obscurin like 1. (1896 aa)
FLNBFilamin B. (2633 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1029 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (846 aa)
SYNPO2Synaptopodin 2. (1261 aa)
ENSMFAP00000037050Uncharacterized protein. (319 aa)
ENSMFAP00000037380Uncharacterized protein. (160 aa)
ITGB1BP2Integrin subunit beta 1 binding protein 2. (348 aa)
TRIM54Tripartite motif containing 54. (402 aa)
FHL2Four and a half LIM domains 2. (389 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
C10orf113Chromosome 10 open reading frame 113. (152 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
MYOZ1Myozenin 1. (299 aa)
SYNE2Spectrin repeat containing nuclear envelope protein 2. (6907 aa)
DSTDystonin. (7466 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
KYKyphoscoliosis peptidase. (720 aa)
RYR1Ryanodine receptor 1. (4309 aa)
FBXO32F-box protein 32. (355 aa)
SPEGNBSPEG neighbor. (238 aa)
PDLIM7PDZ and LIM domain 7. (441 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
MYOZ2Myozenin 2. (264 aa)
FBXO22F-box protein 22. (404 aa)
IGSF22Immunoglobulin superfamily member 22. (1326 aa)
CAB39Calcium binding protein 39. (341 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
JPH1Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (661 aa)
FBXL22F-box and leucine rich repeat protein 22. (236 aa)
CACNA1CCalcium voltage-gated channel subunit alpha1 C. (1987 aa)
DESDesmin; Belongs to the intermediate filament family. (470 aa)
PARVAParvin alpha. (412 aa)
CSRP2Cysteine and glycine rich protein 2. (243 aa)
ENSMFAP00000000909CS domain-containing protein. (117 aa)
UNC45BUnc-45 myosin chaperone B. (929 aa)
SLC4A1Anion exchange protein. (849 aa)
ENSMFAP00000045970Uncharacterized protein. (144 aa)
FLNCUncharacterized protein. (2700 aa)
TCAPUncharacterized protein. (167 aa)
NEXNNexilin F-actin binding protein. (675 aa)
SRISorcin. (198 aa)
PALLDPalladin, cytoskeletal associated protein. (1124 aa)
MYPNMyopalladin. (1320 aa)
RYR2Ryanodine receptor 2. (4943 aa)
AKAP4A-kinase anchoring protein 4. (854 aa)
HOMER1Homer scaffold protein 1. (358 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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