Your Input: | |
| | MAD2L1BP | MAD2L1 binding protein. (274 aa) |
| | ENSMFAP00000013834 | HORMA domain-containing protein. (205 aa) |
| | ENSMFAP00000012561 | HORMA domain-containing protein. (205 aa) |
| | SPDL1 | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various [...] (622 aa) |
| | ZWILCH | Zwilch kinetochore protein. (591 aa) |
| | IK | IK cytokine, down-regulator of HLA II. (557 aa) |
| | CDC20 | WD_REPEATS_REGION domain-containing protein. (499 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (934 aa) |
| | USP44 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (713 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | ZWINT | ZW10 interacting kinetochore protein. (277 aa) |
| | CDK5RAP2 | CDK5 regulatory subunit-associated protein 2; Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of [...] (1924 aa) |
| | BIRC5 | Uncharacterized protein. (209 aa) |
| | LCMT1 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (335 aa) |
| | PRAP1 | Uncharacterized protein. (153 aa) |
| | SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (376 aa) |
| | PSMG2 | Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (264 aa) |
| | NDC80 | Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spind [...] (642 aa) |
| | RB1 | RB transcriptional corepressor 1. (928 aa) |
| | ENSMFAP00000009917 | Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (264 aa) |
| | ZW10 | Zw10 kinetochore protein. (778 aa) |
| | CDC26 | Cell division cycle 26. (85 aa) |
| | NUF2 | NUF2 component of NDC80 kinetochore complex. (464 aa) |
| | ENSMFAP00000012317 | Uncharacterized protein. (59 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (599 aa) |
| | SPC24 | SPC24 component of NDC80 kinetochore complex. (197 aa) |
| | SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1270 aa) |
| | ESPL1 | Extra spindle pole bodies like 1, separase. (2120 aa) |
| | DYNC1LI1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (466 aa) |
| | INCENP | Inner centromere protein. (897 aa) |
| | BUB1B | BUB1 N-terminal domain-containing protein. (1050 aa) |
| | BCL7C | BAF chromatin remodeling complex subunit BCL7C. (242 aa) |
| | SMARCD3 | SWIB domain-containing protein. (483 aa) |
| | TEX14 | Testis expressed 14, intercellular bridge forming factor. (1497 aa) |
| | ARID1A | AT-rich interaction domain 1A. (2268 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | TPR | Translocated promoter region, nuclear basket protein. (2439 aa) |
| | RIOK2 | RIO kinase 2. (551 aa) |
| | ENSMFAP00000020443 | Rad21_Rec8 domain-containing protein. (521 aa) |
| | DPF3 | Double PHD fingers 3. (275 aa) |
| | SPC25 | SPC25 component of NDC80 kinetochore complex. (224 aa) |
| | ARID1B | AT-rich interaction domain 1B. (2295 aa) |
| | DLGAP5 | DLG associated protein 5. (851 aa) |
| | PBRM1 | Polybromo 1. (1725 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1077 aa) |
| | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa) |
| | MAD2L1 | Mitotic spindle assembly checkpoint protein MAD2. (205 aa) |
| | NEK6 | NIMA related kinase 6; Belongs to the protein kinase superfamily. (347 aa) |
| | BIRC5-2 | Uncharacterized protein. (142 aa) |
| | ANAPC11 | Anaphase promoting complex subunit 11. (180 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (246 aa) |
| | SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa) |
| | DPF1 | Double PHD fingers 1. (424 aa) |
| | CDC16 | Cell division cycle 16. (526 aa) |
| | FBXO5 | F-box protein 5. (448 aa) |
| | KNTC1 | Kinetochore associated 1. (2192 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (347 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (450 aa) |
| | DUSP1 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) |
| | CDC27 | Cell division cycle 27. (830 aa) |
| | PHF10 | PHD finger protein 10. (469 aa) |
| | ENSMFAP00000026582 | HMG box domain-containing protein. (177 aa) |
| | BCL7A | BAF chromatin remodeling complex subunit BCL7A. (223 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (768 aa) |
| | ANAPC15 | Anaphase promoting complex subunit 15. (190 aa) |
| | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1091 aa) |
| | TRIP13 | Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa) |
| | PCID2 | PCI domain containing 2. (453 aa) |
| | HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1572 aa) |
| | SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1569 aa) |
| | ANAPC4 | Anaphase promoting complex subunit 4. (981 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (345 aa) |
| | SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (493 aa) |
| | BCL7B | BAF chromatin remodeling complex subunit BCL7B. (202 aa) |
| | CENPF | Centromere protein F. (3113 aa) |
| | ARID2 | AT-rich interaction domain 2. (1815 aa) |
| | ACTL6B | Actin like 6B; Belongs to the actin family. (426 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (718 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (603 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | APC | APC regulator of WNT signaling pathway. (2861 aa) |
| | CCNB1 | Cyclin B1. (356 aa) |
| | CENPE | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2701 aa) |
| | KLHL22 | Kelch like family member 22. (634 aa) |
| | SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa) |
| | DPF2 | Double PHD fingers 2. (405 aa) |
