STRINGSTRING
ENSMFAP00000012290 ENSMFAP00000012290 WNT3A WNT3A CTSL CTSL RAB24 RAB24 LRP2 LRP2 ATP6V0B ATP6V0B TLR7 TLR7 SGIP1 SGIP1 EHD2 EHD2 ANXA11 ANXA11 SMO SMO CLTA CLTA STAB1 STAB1 LOC102141835 LOC102141835 STX4 STX4 LOC102123548 LOC102123548 TGFA TGFA RAB38 RAB38 LOC102132408 LOC102132408 MYO1C MYO1C ATP6V0A4 ATP6V0A4 PIP4P2 PIP4P2 SCIMP SCIMP CLEC4E CLEC4E RINL RINL SLC11A1 SLC11A1 ZYX ZYX RAB22A RAB22A CD36 CD36 ATP6V0C ATP6V0C WNT7B WNT7B RAPGEF2 RAPGEF2 SH3GL2 SH3GL2 APPL2 APPL2 HBEGF HBEGF AVPR2 AVPR2 UNC93B1 UNC93B1 RAB39A RAB39A WNT6 WNT6 SYT7 SYT7 WASL WASL LYN LYN ADAM8 ADAM8 RABGEF1 RABGEF1 SCGB3A2 SCGB3A2 PLEKHG5 PLEKHG5 CACNG4 CACNG4 RAB8A RAB8A OCRL OCRL GNLY GNLY FMNL1 FMNL1 PLA2G5 PLA2G5 SYK SYK CACNG8 CACNG8 EHD3 EHD3 EPGN EPGN AP2B1 AP2B1 VPS9D1 VPS9D1 STX6 STX6 SPHK1 SPHK1 CLTCL1 CLTCL1 CSF3R CSF3R HEATR5B HEATR5B DYSF DYSF RAB23 RAB23 DLG4 DLG4 CYBA CYBA AMOT AMOT STX8 STX8 PTCH1 PTCH1 SCARF1 SCARF1 RAB7B RAB7B VAMP4 VAMP4 TF TF AP2A2 AP2A2 ZDHHC5 ZDHHC5 MSR1 MSR1 HEATR5A HEATR5A CEMIP CEMIP LAMP1 LAMP1 RAB20 RAB20 VAMP7 VAMP7 ROR2 ROR2 CUBN CUBN CORO1A CORO1A CD163 CD163 MYO6 MYO6 KIAA0319 KIAA0319 TCIRG1 TCIRG1 MPO MPO WNT3 WNT3 TLR1 TLR1 LMBRD1 LMBRD1 LAMP2 LAMP2 AP2S1 AP2S1 RAB11FIP5 RAB11FIP5 AP2M1 AP2M1 CDC42EP2 CDC42EP2 RAB9A RAB9A RIN3 RIN3 HVCN1 HVCN1 ENSMFAP00000012235 ENSMFAP00000012235 FZD5 FZD5 TLR2 TLR2 RAB9B RAB9B HGS HGS ENSMFAP00000010727 ENSMFAP00000010727 ITGB5 ITGB5 SLC18A3 SLC18A3 LOC101864869 LOC101864869 MPEG1 MPEG1 DQB1 DQB1 ENSMFAP00000009883 ENSMFAP00000009883 LOC102136620 LOC102136620 EREG EREG APPL1 APPL1 TAPBP TAPBP RILP RILP FCGR1A FCGR1A ARRB2 ARRB2 HLA-DRB5 HLA-DRB5 CD74 CD74 NCF2 NCF2 RAB8B RAB8B RAB13 RAB13 CAMK2D CAMK2D AREG AREG CYBB CYBB RAB11FIP4 RAB11FIP4 ENSMFAP00000006752 ENSMFAP00000006752 ATG14 ATG14 RAB7A RAB7A WAS WAS LOC102125623 LOC102125623 RAB5A RAB5A ABCA1 ABCA1 CD207 CD207 AMBRA1 AMBRA1 NOS3 NOS3 HYOU1 HYOU1 MCOLN1 MCOLN1 UVRAG UVRAG RAB10 RAB10 CSF3 CSF3 CLTB CLTB ARF6 ARF6 LOC102140782 LOC102140782 STXBP4 STXBP4 SLC2A8 SLC2A8 LPAR2 LPAR2 SYT2 SYT2 RAB34 RAB34 HLA-DPA1 HLA-DPA1 APOB APOB PLD4 PLD4 AVP AVP RAB35 RAB35 SLAMF1 SLAMF1 ENSMFAP00000041088 ENSMFAP00000041088 ELANE ELANE MTSS1 MTSS1 PIKFYVE PIKFYVE DPP4 DPP4 ECPAS ECPAS RAB11FIP1 RAB11FIP1 FFAR4 FFAR4 LDLR LDLR TIRAP TIRAP AP2A1 AP2A1 INPP5F INPP5F ENSMFAP00000030298 ENSMFAP00000030298 SFTA3 SFTA3 CD2AP CD2AP DAB2IP DAB2IP EHD4 EHD4 CTLA4 CTLA4 ENSMFAP00000031156 ENSMFAP00000031156 HLA-DPB1 HLA-DPB1 RAB17 RAB17 TGOLN2 TGOLN2 SH3KBP1 SH3KBP1 RIN2 RIN2 ANXA3 ANXA3 PLD1 PLD1 M6PR M6PR NCF4 NCF4 VIM VIM PIK3C2B PIK3C2B GAPVD1 GAPVD1 STX12 STX12 KIF5B KIF5B RAB11B RAB11B ENSMFAP00000034437 ENSMFAP00000034437 STX7 STX7 EGF EGF CAMK2B CAMK2B ITGAV ITGAV AVPR1A AVPR1A DMBT1 DMBT1 PICALM PICALM SRGAP2 SRGAP2 WNT5A WNT5A PIK3C3 PIK3C3 IGF2R IGF2R CACNG2 CACNG2 FZD4 FZD4 INPP5B INPP5B RAB32 RAB32 NOD1 NOD1 ENSMFAP00000036248 ENSMFAP00000036248 VAMP8 VAMP8 CD9 CD9 STAB2 STAB2 FLNB FLNB IRGM IRGM WNT1 WNT1 OCLN OCLN RAB11FIP3 RAB11FIP3 ENSMFAP00000036774 ENSMFAP00000036774 NOD2 NOD2 RPS27A RPS27A NCF1 NCF1 LTF LTF SYT9 SYT9 FZD2 FZD2 GPR161 GPR161 SPARC SPARC VPS26B VPS26B NRXN1 NRXN1 RAB31 RAB31 CTSS CTSS WNT4 WNT4 EPN2 EPN2 DNM2 DNM2 RAB14 RAB14 TYRP1 TYRP1 GSN GSN FLOT2 FLOT2 ATP6V0A2 ATP6V0A2 SNAP23 SNAP23 ENSMFAP00000042377 ENSMFAP00000042377 MTOR MTOR RAB43 RAB43 TRIM14 TRIM14 RIN1 RIN1 LOC102144128 LOC102144128 ATP7A ATP7A ENSMFAP00000043217 ENSMFAP00000043217 PIP4P1 PIP4P1 SNX3 SNX3 SCARB2 SCARB2 CLTC CLTC SYT11 SYT11 STAM2 STAM2 LRP1 LRP1 SFTPB SFTPB BTC BTC ENSMFAP00000044760 ENSMFAP00000044760 DVL2 DVL2 VPS11 VPS11 SCARB1 SCARB1 RABEP1 RABEP1 RAC2 RAC2 STXBP3 STXBP3 RAB11A RAB11A HYAL2 HYAL2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ENSMFAP00000012290Ubiquitin-like domain-containing protein. (156 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
RAB24RAB24, member RAS oncogene family. (203 aa)
LRP2LDL receptor related protein 2. (4655 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (259 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
SGIP1SH3 domain GRB2 like endophilin interacting protein 1. (859 aa)
EHD2Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (436 aa)
ANXA11Annexin. (506 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
STAB1Stabilin 1. (2568 aa)
LOC102141835Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (171 aa)
LOC102123548Ig-like domain-containing protein; Belongs to the MHC class I family. (363 aa)
TGFATransforming growth factor alpha. (166 aa)
RAB38RAB38, member RAS oncogene family. (211 aa)
LOC102132408Ig-like domain-containing protein; Belongs to the MHC class I family. (402 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
SCIMPSLP adaptor and CSK interacting membrane protein. (143 aa)
CLEC4EC-type lectin domain family 4 member E. (219 aa)
RINLRas and Rab interactor like. (566 aa)
SLC11A1Solute carrier family 11 member 1. (547 aa)
ZYXZyxin. (572 aa)
RAB22ARAB22A, member RAS oncogene family. (194 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (128 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1701 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (341 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (666 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (368 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (597 aa)
RAB39ARAB39A, member RAS oncogene family. (217 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SYT7Synaptotagmin 7. (686 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
LYNTyrosine-protein kinase. (512 aa)
ADAM8ADAM metallopeptidase domain 8. (893 aa)
RABGEF1Uncharacterized protein. (507 aa)
SCGB3A2Secretoglobin family 3A member 2. (93 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1154 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
RAB8ARas-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (901 aa)
GNLYGranulysin. (153 aa)
FMNL1Formin like 1. (1107 aa)
PLA2G5Phospholipase A(2). (138 aa)
SYKTyrosine-protein kinase. (635 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (320 aa)
EHD3EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
EPGNEpithelial mitogen. (154 aa)
AP2B1AP complex subunit beta. (951 aa)
VPS9D1VPS9 domain containing 1. (572 aa)
STX6Syntaxin 6; Belongs to the syntaxin family. (255 aa)
SPHK1Sphingosine kinase 1. (470 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1640 aa)
CSF3RColony stimulating factor 3 receptor. (836 aa)
HEATR5BHEAT repeat containing 5B. (2161 aa)
DYSFDysferlin. (2070 aa)
RAB23RAB23, member RAS oncogene family. (237 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
AMOTAngiomotin. (1099 aa)
STX8Syntaxin 8. (236 aa)
PTCH1Patched 1. (1398 aa)
SCARF1Scavenger receptor class F member 1. (830 aa)
RAB7BRAB7B, member RAS oncogene family. (189 aa)
VAMP4Vesicle associated membrane protein 4. (141 aa)
TFTransferrin; Belongs to the transferrin family. (698 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (940 aa)
ZDHHC5Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (715 aa)
MSR1Macrophage scavenger receptor 1. (451 aa)
HEATR5AHEAT repeat containing 5A. (2027 aa)
CEMIPCell migration inducing hyaluronidase 1. (1361 aa)
LAMP1Lysosomal associated membrane protein 1. (423 aa)
RAB20RAB20, member RAS oncogene family. (234 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
CUBNCubilin. (3624 aa)
CORO1ACoronin-1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. (461 aa)
CD163CD163 molecule. (1153 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1290 aa)
KIAA0319KIAA0319. (1072 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
MPOMyeloperoxidase. (745 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
TLR1Toll-like receptor. (786 aa)
LMBRD1Probable lysosomal cobalamin transporter; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity). (540 aa)
LAMP2Lysosomal associated membrane protein 2. (411 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
RAB11FIP5Uncharacterized protein. (1319 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
CDC42EP2Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (210 aa)
RAB9ARAB9A, member RAS oncogene family. (201 aa)
RIN3Ras and Rab interactor 3. (883 aa)
HVCN1Hydrogen voltage gated channel 1. (273 aa)
ENSMFAP00000012235Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (830 aa)
ENSMFAP00000010727Uncharacterized protein. (98 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
SLC18A3Solute carrier family 18 member A3. (532 aa)
LOC101864869Ubiquitin-like domain-containing protein. (156 aa)
MPEG1Macrophage expressed 1. (696 aa)
DQB1Ig-like domain-containing protein. (156 aa)
ENSMFAP00000009883Ubiquitin-like domain-containing protein. (147 aa)
LOC102136620Uncharacterized protein. (64 aa)
EREGEpiregulin. (169 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (715 aa)
TAPBPTAP binding protein. (504 aa)
RILPRab interacting lysosomal protein. (395 aa)
FCGR1AUncharacterized protein. (375 aa)
ARRB2Arrestin beta 2. (454 aa)
HLA-DRB5Ig-like domain-containing protein. (286 aa)
CD74CD74 molecule. (294 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
RAB8BRAB8B, member RAS oncogene family. (207 aa)
RAB13Uncharacterized protein. (203 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
AREGAmphiregulin. (274 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
RAB11FIP4RAB11 family interacting protein 4. (634 aa)
ENSMFAP00000006752INPP5B_PH domain-containing protein. (224 aa)
ATG14Autophagy related 14. (510 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
WASWASP actin nucleation promoting factor. (503 aa)
LOC102125623Ig-like domain-containing protein; Belongs to the MHC class I family. (389 aa)
RAB5ARas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)
ABCA1ATP binding cassette subfamily A member 1. (2268 aa)
CD207CD207 molecule. (328 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
HYOU1Hypoxia up-regulated 1. (999 aa)
MCOLN1Mucolipin-1; Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion. Involved [...] (580 aa)
UVRAGUV radiation resistance associated. (699 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
CSF3Colony stimulating factor 3. (207 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa)
LOC102140782Ig-like domain-containing protein. (325 aa)
STXBP4Syntaxin binding protein 4. (555 aa)
SLC2A8Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
LPAR2Lysophosphatidic acid receptor 2; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (By similarity). (351 aa)
SYT2Synaptotagmin 2. (419 aa)
RAB34Uncharacterized protein. (263 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
APOBApolipoprotein B. (4555 aa)
PLD4Phospholipase D family member 4. (506 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
RAB35RAB35, member RAS oncogene family. (201 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (356 aa)
ENSMFAP00000041088Ig-like domain-containing protein; Belongs to the MHC class I family. (400 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (264 aa)
MTSS1MTSS I-BAR domain containing 1. (795 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (766 aa)
ECPASEcm29 proteasome adaptor and scaffold. (1955 aa)
RAB11FIP1RAB11 family interacting protein 1. (1275 aa)
FFAR4Free fatty acid receptor 4; Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega- 3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)- coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates [...] (377 aa)
LDLRLow density lipoprotein receptor. (860 aa)
TIRAPTIR domain-containing protein. (234 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1133 aa)
ENSMFAP00000030298Ig-like domain-containing protein; Belongs to the MHC class I family. (492 aa)
SFTA3Surfactant associated 3. (93 aa)
CD2APCD2 associated protein. (639 aa)
DAB2IPDAB2 interacting protein. (1153 aa)
EHD4EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (541 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
ENSMFAP00000031156VPS9 domain-containing protein. (363 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (264 aa)
RAB17RAB17, member RAS oncogene family. (212 aa)
TGOLN2Trans-golgi network protein 2. (417 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (665 aa)
RIN2Ras and Rab interactor 2. (895 aa)
ANXA3Annexin. (323 aa)
PLD1Phospholipase. (1074 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (278 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
VIMVimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (466 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
GAPVD1GTPase activating protein and VPS9 domains 1. (1487 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (276 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (964 aa)
RAB11BUncharacterized protein. (460 aa)
ENSMFAP00000034437Ig-like domain-containing protein; Belongs to the MHC class I family. (394 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (261 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (644 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
DMBT1Deleted in malignant brain tumors 1. (2145 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (686 aa)
SRGAP2Uncharacterized protein. (1071 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
IGF2RInsulin like growth factor 2 receptor. (2491 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (524 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (829 aa)
RAB32Uncharacterized protein. (225 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
ENSMFAP00000036248MACPF domain-containing protein. (609 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
CD9Tetraspanin. (228 aa)
STAB2Stabilin 2. (2554 aa)
FLNBFilamin B. (2633 aa)
IRGMImmunity related GTPase M. (159 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (546 aa)
RAB11FIP3RAB11 family interacting protein 3. (680 aa)
ENSMFAP00000036774Ig-like domain-containing protein; Belongs to the MHC class I family. (365 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1117 aa)
RPS27ABrain cDNA, clone: QccE-15346, similar to human ribosomal protein S27a (RPS27A). (156 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
LTFLactotransferrin; Belongs to the transferrin family. (710 aa)
SYT9Synaptotagmin 9. (491 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (562 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (550 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
VPS26BVPS26, retromer complex component B. (336 aa)
NRXN1Neurexin 1. (1507 aa)
RAB31RAB31, member RAS oncogene family. (194 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (331 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
EPN2Epsin 2. (641 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
TYRP1Tyrosinase related protein 1. (537 aa)
GSNGelsolin. (784 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (483 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (552 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
ENSMFAP00000042377Uncharacterized protein. (251 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
RAB43RAB43, member RAS oncogene family. (212 aa)
TRIM14Tripartite motif containing 14. (442 aa)
RIN1Ras and Rab interactor 1. (783 aa)
LOC102144128TIR domain-containing protein. (1033 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
ENSMFAP00000043217Ig-like domain-containing protein; Belongs to the MHC class I family. (384 aa)
PIP4P1Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrog [...] (277 aa)
SNX3Sorting nexin 3. (162 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (478 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
SYT11Uncharacterized protein. (431 aa)
STAM2Signal transducing adaptor molecule 2. (525 aa)
LRP1LDL receptor related protein 1. (4544 aa)
SFTPBSurfactant protein B. (393 aa)
BTCBetacellulin. (178 aa)
ENSMFAP00000044760Uncharacterized protein. (215 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
VPS11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
RABEP1Rabaptin, RAB GTPase binding effector protein 1. (872 aa)
RAC2Rac family small GTPase 2. (192 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
RAB11ARAB11A, member RAS oncogene family. (216 aa)
HYAL2Hyaluronidase. (473 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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