STRINGSTRING
ENSMFAP00000029266 ENSMFAP00000029266 TGFB1 TGFB1 HJV HJV USP15 USP15 LEFTY1 LEFTY1 SCX SCX SMAD3 SMAD3 CHRD CHRD PDCD4 PDCD4 EXT1 EXT1 RGMB RGMB TGFBR3 TGFBR3 TGFB2 TGFB2 SMPD3 SMPD3 ATF2 ATF2 BMPR1A BMPR1A GDF7 GDF7 BMP6 BMP6 ZNF831 ZNF831 BMP4 BMP4 NOTCH2 NOTCH2 ZNF8 ZNF8 HFE HFE SLC33A1 SLC33A1 SOSTDC1 SOSTDC1 TGFB3 TGFB3 NOG NOG EGR1 EGR1 DDX5 DDX5 TMEM100 TMEM100 ZCCHC12 ZCCHC12 FST FST BMP5 BMP5 RGMA RGMA DSG4 DSG4 GDF2 GDF2 USP9X USP9X BMPR2 BMPR2 BMP7 BMP7 DLX3 DLX3 HIVEP1 HIVEP1 SPART SPART SFRP1 SFRP1 SMURF1 SMURF1 TMPRSS6 TMPRSS6 DLX5 DLX5 SMAD7 SMAD7 MEGF8 MEGF8 BMP2 BMP2 FAM83G FAM83G SLC39A5 SLC39A5 SMAD9 SMAD9 SMAD6 SMAD6 SOST SOST MAPK3 MAPK3 ETV2 ETV2 ACVR1 ACVR1 CCDC142 CCDC142 GDF5 GDF5 BMPR1B BMPR1B SMAD4 SMAD4 LEF1 LEF1 ENSMFAP00000032703 ENSMFAP00000032703 ACVR2A ACVR2A COMP COMP ENSMFAP00000035525 ENSMFAP00000035525 WNT5A WNT5A RUNX2 RUNX2 TWSG1 TWSG1 ENG ENG FKBP8 FKBP8 SMAD1 SMAD1 SFRP2 SFRP2 BMP10 BMP10 ACVR2B ACVR2B ENSMFAP00000041061 ENSMFAP00000041061 NODAL NODAL ACVRL1 ACVRL1 GDF3 GDF3 CHRDL1 CHRDL1 MSX1 MSX1 SMAD5 SMAD5 LOC102144954 LOC102144954 BMPER BMPER GDF6 GDF6 ABL1 ABL1 BMP15 BMP15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMFAP00000029266TGF_BETA_2 domain-containing protein. (344 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
HJVHemojuvelin BMP co-receptor. (427 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
LEFTY1Left-right determination factor. (366 aa)
SCXScleraxis bHLH transcription factor. (145 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
PDCD4Programmed cell death 4. (471 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (479 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GDF7Growth differentiation factor 7. (450 aa)
BMP6Bone morphogenetic protein 6. (509 aa)
ZNF831Zinc finger protein 831. (1663 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
NOTCH2Notch receptor 2. (2610 aa)
ZNF8Zinc finger protein 8. (575 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
SLC33A1Uncharacterized protein. (291 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa)
TMEM100Uncharacterized protein. (134 aa)
ZCCHC12Zinc finger CCHC-type containing 12. (402 aa)
FSTFollistatin. (344 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
RGMARepulsive guidance molecule A; Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA- ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG- PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inacti [...] (458 aa)
DSG4Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1041 aa)
GDF2Growth differentiation factor 2. (429 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2584 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
DLX3Distal-less homeobox 3. (287 aa)
HIVEP1Human immunodeficiency virus type I enhancer binding protein 1. (2718 aa)
SPARTSpartin. (666 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (821 aa)
DLX5Distal-less homeobox 5. (289 aa)
SMAD7Mothers against decapentaplegic homolog. (495 aa)
MEGF8Multiple EGF like domains 8. (2840 aa)
BMP2Bone morphogenetic protein 2. (544 aa)
FAM83GFamily with sequence similarity 83 member G. (823 aa)
SLC39A5Solute carrier family 39 member 5. (540 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
SOSTSclerostin. (213 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
ETV2ETS variant 2. (376 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
CCDC142Coiled-coil domain containing 142. (743 aa)
GDF5Growth differentiation factor 5. (499 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
ENSMFAP00000032703Uncharacterized protein. (103 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
ENSMFAP00000035525TGF_BETA_2 domain-containing protein. (347 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
RUNX2RUNX family transcription factor 2. (627 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
ENGEndoglin. (555 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
ENSMFAP00000041061TPR_REGION domain-containing protein. (134 aa)
NODALNodal growth differentiation factor. (347 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
GDF3Growth differentiation factor 3. (364 aa)
CHRDL1Chordin like 1. (458 aa)
MSX1Msh homeobox 1. (303 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
LOC102144954Left-right determination factor. (366 aa)
BMPERBMP binding endothelial regulator. (685 aa)
GDF6Growth differentiation factor 6. (455 aa)
ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase. (901 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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