(85 nodes) Negative regulation of transforming growth factor beta receptor signaling pathway network (Macaca fascicularis)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	CHST11	Carbohydrate sulfotransferase. (352 aa)
	DAND5	DAN domain BMP antagonist family member 5. (189 aa)
	ENSMFAP00000043889	Uncharacterized protein; Belongs to the heat shock protein 70 family. (619 aa)
	FBN1	Fibrillin 1. (2871 aa)
	ADAM17	ADAM metallopeptidase domain 17. (824 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis- promoting activity. Down-regulates kinase activity of BTK. Can transactivate multiple [...] (145 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (467 aa)
	NKX2-1	NK2 homeobox 1. (448 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	SIRT1	Sirtuin 1. (743 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
	BCL9L	BCL9 like. (1500 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa)
	BRMS1L	BRMS1 like transcriptional repressor. (323 aa)
	SAP30	Sin3A associated protein 30. (220 aa)
	SNX25	Sorting nexin 25. (879 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	ENG	Endoglin. (555 aa)
	IL17RD	Interleukin 17 receptor D. (739 aa)
	SLC2A10	Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (555 aa)
	NRROS	Negative regulator of reactive oxygen species. (732 aa)
	CIDEA	Cell death inducing DFFA like effector a. (219 aa)
	STUB1	STIP1 homology and U-box containing protein 1. (303 aa)
	SPINT3	Serine peptidase inhibitor, Kunitz type 3. (89 aa)
	FBN2	Fibrillin 2. (2912 aa)
	HTRA4	HtrA serine peptidase 4. (476 aa)
	WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (576 aa)
	PMEPA1	Prostate transmembrane protein, androgen induced 1. (287 aa)
	LEMD3	LEM domain containing 3. (909 aa)
	SMAD6	Mothers against decapentaplegic homolog. (496 aa)
	CD109	CD109 molecule. (1444 aa)
	HTRA1	HtrA serine peptidase 1. (481 aa)
	TET1	Tet methylcytosine dioxygenase 1. (2132 aa)
	LTBP1	Latent transforming growth factor beta binding protein 1. (1683 aa)
	ARID4B	AT-rich interaction domain 4B. (1314 aa)
	BMP2	Bone morphogenetic protein 2. (544 aa)
	ING1	Inhibitor of growth protein. (417 aa)
	FAM89B	Family with sequence similarity 89 member B. (154 aa)
	ZNF451	Zinc finger protein 451. (1061 aa)
	VEPH1	Ventricular zone expressed PH domain containing 1. (833 aa)
	SMAD7	Mothers against decapentaplegic homolog. (495 aa)
	SMURF1	E3 ubiquitin-protein ligase. (757 aa)
	PBLD	Phenazine biosynthesis like protein domain containing. (288 aa)
	ASPN	Asporin. (333 aa)
	ING2	Inhibitor of growth protein. (280 aa)
	ONECUT2	One cut domain family member. (481 aa)
	SKI	SKI proto-oncogene. (681 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (444 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (467 aa)
	SPRED3	Sprouty related EVH1 domain containing 3. (424 aa)
	ENSMFAP00000016148	PPM-type phosphatase domain-containing protein. (280 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (432 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (510 aa)
	WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (548 aa)
	ENSMFAP00000014529	Uncharacterized protein. (106 aa)
	SKIL	SKI like proto-oncogene. (684 aa)
	EMILIN1	Elastin microfibril interfacer 1. (1016 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	VASN	Vasorin. (673 aa)
	GLG1	Golgi glycoprotein 1. (1203 aa)
	LINGO3	Leucine rich repeat and Ig domain containing 3. (592 aa)
	SKOR2	SKI family transcriptional corepressor 2. (911 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (319 aa)
	LDLRAD4	Uncharacterized protein. (306 aa)
	STRAP	WD_REPEATS_REGION domain-containing protein. (363 aa)
	ZBTB7A	Zinc finger and BTB domain containing 7A. (584 aa)
	HTRA3	HtrA serine peptidase 3. (453 aa)
	SIN3A	SIN3 transcription regulator family member A. (1273 aa)
	SMURF2	E3 ubiquitin-protein ligase. (748 aa)
	SAP130	Sin3A associated protein 130. (1083 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (851 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
	ADAMTSL2	ADAMTS like 2. (1049 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	RASL11B	RAS like family 11 member B. (248 aa)
	EID2	EP300 interacting inhibitor of differentiation 2. (236 aa)
	XBP1	BZIP domain-containing protein. (380 aa)
	SPRY2	Protein sprouty homolog 2; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. (338 aa)
	PRDM16	PR/SET domain 16. (1276 aa)
	MTMR4	Myotubularin related protein 4. (1195 aa)
	BRMS1	Uncharacterized protein. (262 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	SAP30L	SAP30 like. (184 aa)

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTSL2	FBN1	ENSMFAP00000003895	ENSMFAP00000043714	ADAMTS like 2.	Fibrillin 1.	0.474
ADAMTSL2	LTBP1	ENSMFAP00000003895	ENSMFAP00000025656	ADAMTS like 2.	Latent transforming growth factor beta binding protein 1.	0.626
ARID4B	BRMS1	ENSMFAP00000025090	ENSMFAP00000000142	AT-rich interaction domain 4B.	Uncharacterized protein.	0.975
ARID4B	BRMS1L	ENSMFAP00000025090	ENSMFAP00000037488	AT-rich interaction domain 4B.	BRMS1 like transcriptional repressor.	0.979
ARID4B	ENSMFAP00000014529	ENSMFAP00000025090	ENSMFAP00000014529	AT-rich interaction domain 4B.	Uncharacterized protein.	0.974
ARID4B	FBN1	ENSMFAP00000025090	ENSMFAP00000043714	AT-rich interaction domain 4B.	Fibrillin 1.	0.406
ARID4B	FBN2	ENSMFAP00000025090	ENSMFAP00000029294	AT-rich interaction domain 4B.	Fibrillin 2.	0.406
ARID4B	HDAC2	ENSMFAP00000025090	ENSMFAP00000000083	AT-rich interaction domain 4B.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.941
ARID4B	ING1	ENSMFAP00000025090	ENSMFAP00000024832	AT-rich interaction domain 4B.	Inhibitor of growth protein.	0.783
ARID4B	ING2	ENSMFAP00000025090	ENSMFAP00000019646	AT-rich interaction domain 4B.	Inhibitor of growth protein.	0.692
ARID4B	LTBP1	ENSMFAP00000025090	ENSMFAP00000025656	AT-rich interaction domain 4B.	Latent transforming growth factor beta binding protein 1.	0.406
ARID4B	SAP130	ENSMFAP00000025090	ENSMFAP00000006338	AT-rich interaction domain 4B.	Sin3A associated protein 130.	0.817
ARID4B	SAP30	ENSMFAP00000025090	ENSMFAP00000037449	AT-rich interaction domain 4B.	Sin3A associated protein 30.	0.974
ARID4B	SAP30L	ENSMFAP00000025090	ENSMFAP00000045172	AT-rich interaction domain 4B.	SAP30 like.	0.969
ARID4B	SIN3A	ENSMFAP00000025090	ENSMFAP00000006874	AT-rich interaction domain 4B.	SIN3 transcription regulator family member A.	0.945
ARID4B	TET1	ENSMFAP00000025090	ENSMFAP00000025846	AT-rich interaction domain 4B.	Tet methylcytosine dioxygenase 1.	0.522
BAMBI	SMAD6	ENSMFAP00000002255	ENSMFAP00000027553	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.726
BAMBI	SMAD7	ENSMFAP00000002255	ENSMFAP00000022604	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.856
BMP2	DAND5	ENSMFAP00000025040	ENSMFAP00000044872	Bone morphogenetic protein 2.	DAN domain BMP antagonist family member 5.	0.410
BMP2	EMILIN1	ENSMFAP00000025040	ENSMFAP00000013511	Bone morphogenetic protein 2.	Elastin microfibril interfacer 1.	0.513

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