STRINGSTRING
ENSMFAP00000035957 ENSMFAP00000035957 SLC6A3 SLC6A3 TGFBR2 TGFBR2 MST1 MST1 JAK2 JAK2 EGF EGF FGF10 FGF10 APRT APRT GPAT4 GPAT4 GLI2 GLI2 AKT2 AKT2 MGMT MGMT LEF1 LEF1 STAT6 STAT6 AR AR ERBB4 ERBB4 IRS2 IRS2 SCRIB SCRIB ZBTB7B ZBTB7B WNT3A WNT3A HOXA5 HOXA5 ARG1 ARG1 SMO SMO EPHA2 EPHA2 PYGO2 PYGO2 TGFA TGFA ENSMFAP00000026709 ENSMFAP00000026709 WNT2 WNT2 RPLP0 RPLP0 WNT7B WNT7B KALRN KALRN CSMD2 CSMD2 CSMD1 CSMD1 ENSMFAP00000023113 ENSMFAP00000023113 HOXB9 HOXB9 TNFRSF11A TNFRSF11A HK2 HK2 DDR1 DDR1 ENSMFAP00000020439 ENSMFAP00000020439 NOTCH4 NOTCH4 TNFSF11 TNFSF11 CSN3 CSN3 STAT5B STAT5B HIF1A HIF1A SRC SRC PTCH1 PTCH1 AKT1 AKT1 ITGA2 ITGA2 GHRHR GHRHR SOCS2 SOCS2 GLI3 GLI3 WNT3 WNT3 ENSMFAP00000012719 ENSMFAP00000012719 TGFB3 TGFB3 ZNF703 ZNF703 KDM5B KDM5B FOXB1 FOXB1 BTRC BTRC SOSTDC1 SOSTDC1 ENSMFAP00000008754 ENSMFAP00000008754 NEURL1 NEURL1 ENSMFAP00000008086 ENSMFAP00000008086 BMP4 BMP4 PAM PAM AREG AREG ELF3 ELF3 CSN2 CSN2 USF2 USF2 XDH XDH TDGF1 TDGF1 PML PML BSX BSX NRG1 NRG1 NCOR2 NCOR2 ENSMFAP00000004931 ENSMFAP00000004931 MAPK1 MAPK1 ENSMFAP00000004476 ENSMFAP00000004476 TPH1 TPH1 ATP7B ATP7B HOXD9 HOXD9 NFKB1 NFKB1 ORAI1 ORAI1 ID2 ID2 CSF1 CSF1 TBX2 TBX2 IQGAP3 IQGAP3 FGFR2 FGFR2 CCND1 CCND1 TGFB1 TGFB1 STAT5A STAT5A PRL PRL AGAP2 AGAP2 ARHGAP5 ARHGAP5 TBX3 TBX3 IRF6 IRF6 CREB1 CREB1 NRG3 NRG3 SLC29A2 SLC29A2 MSX1 MSX1 BCL2L11 BCL2L11 ESR1 ESR1 ENSMFAP00000043205 ENSMFAP00000043205 ATP7A ATP7A LATS1 LATS1 IGFBP5 IGFBP5 LRRC1 LRRC1 FOXF1 FOXF1 PRLR PRLR ATP2C2 ATP2C2 ARHGAP35 ARHGAP35 CEBPB CEBPB CAV1 CAV1 MED1 MED1 WNT4 WNT4 FASN FASN CYP19A1 CYP19A1 VDR VDR SLC29A1 SLC29A1 NTN1 NTN1 CSF1R CSF1R WNT5A WNT5A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMFAP00000035957Rho-GAP domain-containing protein. (206 aa)
SLC6A3Sodium-dependent dopamine transporter; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity); Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. (620 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
APRTAdenine phosphoribosyltransferase. (206 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4. (456 aa)
GLI2GLI family zinc finger 2. (1561 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (238 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (895 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
IRS2Insulin receptor substrate 2. (1279 aa)
SCRIBScribble planar cell polarity protein. (1662 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
HOXA5Homeobox A5. (270 aa)
ARG1Arginase. (322 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
EPHA2Ephrin type-A receptor 2; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin- A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DS [...] (1036 aa)
PYGO2Pygopus family PHD finger 2. (408 aa)
TGFATransforming growth factor alpha. (166 aa)
ENSMFAP00000026709CFC domain-containing protein. (170 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
RPLP0RL10P_insert domain-containing protein. (329 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
KALRNKalirin RhoGEF kinase. (2986 aa)
CSMD2CUB and Sushi multiple domains 2. (3631 aa)
CSMD1CUB and Sushi multiple domains 1. (3565 aa)
ENSMFAP00000023113RL10P_insert domain-containing protein. (290 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (267 aa)
TNFRSF11ATNF receptor superfamily member 11a. (615 aa)
HK2Hexokinase 2. (913 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (920 aa)
ENSMFAP00000020439RL10P_insert domain-containing protein. (234 aa)
NOTCH4Notch receptor 4. (2000 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
CSN3Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family. (182 aa)
STAT5BSignal transducer and activator of transcription. (763 aa)
HIF1AUncharacterized protein. (831 aa)
SRCTyrosine-protein kinase. (542 aa)
PTCH1Patched 1. (1398 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (393 aa)
SOCS2Suppressor of cytokine signaling 2. (212 aa)
GLI3GLI family zinc finger 3. (1579 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ENSMFAP00000012719PlsC domain-containing protein. (327 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ZNF703Zinc finger protein 703. (591 aa)
KDM5BLysine demethylase 5B. (1580 aa)
FOXB1Forkhead box B1. (325 aa)
BTRCUncharacterized protein. (605 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
ENSMFAP00000008754RL10P_insert domain-containing protein. (173 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
ENSMFAP00000008086Uncharacterized protein. (466 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (976 aa)
AREGAmphiregulin. (274 aa)
ELF3E74 like ETS transcription factor 3. (371 aa)
CSN2Beta-casein; Important role in determination of the surface properties of the casein micelles. (226 aa)
USF2Upstream transcription factor 2, c-fos interacting. (380 aa)
XDHXanthine dehydrogenase. (1333 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (182 aa)
PMLPromyelocytic leukemia. (882 aa)
BSXBrain specific homeobox. (232 aa)
NRG1Neuregulin 1. (713 aa)
NCOR2Nuclear receptor corepressor 2. (2510 aa)
ENSMFAP0000000493160S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (304 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ENSMFAP00000004476RL10P_insert domain-containing protein. (270 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
ATP7BATPase copper transporting beta. (1465 aa)
HOXD9Homeobox D9. (345 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (289 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
CSF1Colony stimulating factor 1. (587 aa)
TBX2T-box transcription factor 2. (639 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1632 aa)
FGFR2Fibroblast growth factor receptor. (810 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
PRLProlactin. (227 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1193 aa)
ARHGAP5Rho GTPase activating protein 5. (1502 aa)
TBX3T-box transcription factor 3. (743 aa)
IRF6Interferon regulatory factor 6. (467 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
NRG3Neuregulin 3. (681 aa)
SLC29A2Solute carrier family 29 member 2. (462 aa)
MSX1Msh homeobox 1. (303 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
ENSMFAP00000043205RL10P_insert domain-containing protein. (146 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
IGFBP5Uncharacterized protein. (272 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
FOXF1Forkhead box F1. (372 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (619 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (975 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
CEBPBCCAAT/enhancer-binding protein. (314 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FASNFatty acid synthase. (2502 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
VDRVitamin D receptor. (477 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (456 aa)
NTN1Netrin 1. (598 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (991 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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