(19 nodes) Retrograde protein transport, ER to cytosol network (Macaca fascicularis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	DERL2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
	UFD1	Ubiquitin recognition factor in ER associated degradation 1. (308 aa)
	SEL1L	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (870 aa)
	OS9	OS9 endoplasmic reticulum lectin. (716 aa)
	AUP1	AUP1 lipid droplet regulating VLDL assembly factor. (410 aa)
	SEC61B	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
	SYVN1	Synoviolin 1. (617 aa)
	SELENOS	Selenoprotein S. (211 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	G8F2K1_MACFA	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
	ENSMFAP00000015333	Uncharacterized protein. (293 aa)
	RHBDD1	Rhomboid domain containing 1. (316 aa)
	DERL1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
	HSP90B1	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. (804 aa)
	HM13	Histocompatibility minor 13. (425 aa)
	FAF2	Fas associated factor family member 2. (445 aa)
	ENSMFAP00000041402	Uncharacterized protein. (155 aa)
	LOC107127874	UN_NPL4 domain-containing protein. (130 aa)
	TMEM129	Transmembrane protein 129. (357 aa)

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AUP1	DERL1	ENSMFAP00000003812	ENSMFAP00000026349	AUP1 lipid droplet regulating VLDL assembly factor.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.421
AUP1	DERL2	ENSMFAP00000003812	ENSMFAP00000030218	AUP1 lipid droplet regulating VLDL assembly factor.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.609
AUP1	FAF2	ENSMFAP00000003812	ENSMFAP00000040285	AUP1 lipid droplet regulating VLDL assembly factor.	Fas associated factor family member 2.	0.636
AUP1	OS9	ENSMFAP00000003812	ENSMFAP00000002952	AUP1 lipid droplet regulating VLDL assembly factor.	OS9 endoplasmic reticulum lectin.	0.568
AUP1	SEL1L	ENSMFAP00000003812	ENSMFAP00000002314	AUP1 lipid droplet regulating VLDL assembly factor.	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.	0.822
AUP1	SYVN1	ENSMFAP00000003812	ENSMFAP00000006201	AUP1 lipid droplet regulating VLDL assembly factor.	Synoviolin 1.	0.762
AUP1	UFD1	ENSMFAP00000003812	ENSMFAP00000001713	AUP1 lipid droplet regulating VLDL assembly factor.	Ubiquitin recognition factor in ER associated degradation 1.	0.454
AUP1	VCP	ENSMFAP00000003812	ENSMFAP00000013931	AUP1 lipid droplet regulating VLDL assembly factor.	Valosin containing protein; Belongs to the AAA ATPase family.	0.638
DERL1	AUP1	ENSMFAP00000026349	ENSMFAP00000003812	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	AUP1 lipid droplet regulating VLDL assembly factor.	0.421
DERL1	DERL2	ENSMFAP00000026349	ENSMFAP00000030218	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.992
DERL1	ENSMFAP00000015333	ENSMFAP00000026349	ENSMFAP00000015333	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein.	0.915
DERL1	ENSMFAP00000041402	ENSMFAP00000026349	ENSMFAP00000041402	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein.	0.431
DERL1	FAF2	ENSMFAP00000026349	ENSMFAP00000040285	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Fas associated factor family member 2.	0.683
DERL1	HM13	ENSMFAP00000026349	ENSMFAP00000038603	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Histocompatibility minor 13.	0.692
DERL1	HSP90B1	ENSMFAP00000026349	ENSMFAP00000032087	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family.	0.431
DERL1	LOC107127874	ENSMFAP00000026349	ENSMFAP00000044698	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	UN_NPL4 domain-containing protein.	0.931
DERL1	OS9	ENSMFAP00000026349	ENSMFAP00000002952	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	OS9 endoplasmic reticulum lectin.	0.969
DERL1	SEL1L	ENSMFAP00000026349	ENSMFAP00000002314	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.	0.959
DERL1	SELENOS	ENSMFAP00000026349	ENSMFAP00000008194	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Selenoprotein S.	0.884
DERL1	SYVN1	ENSMFAP00000026349	ENSMFAP00000006201	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Synoviolin 1.	0.976

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