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| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | RPE65 | Retinoid isomerohydrolase / lutein isomerase. (533 aa) |
| | PTPRA | Receptor-type tyrosine-protein phosphatase alpha. (802 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | PRLH | Prolactin releasing hormone. (85 aa) |
| | BAIAP2 | Uncharacterized protein. (552 aa) |
| | FOXO4 | Forkhead box O4. (505 aa) |
| | ENSMFAP00000022848 | Uncharacterized protein. (81 aa) |
| | SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1077 aa) |
| | SESN2 | Sestrin 2. (480 aa) |
| | EGR2 | Early growth response 2. (489 aa) |
| | INHBB | Inhibin subunit beta B. (360 aa) |
| | DNAI1 | Dynein axonemal intermediate chain 1. (700 aa) |
| | ABCC8 | ATP binding cassette subfamily C member 8. (1582 aa) |
| | KAT2B | Lysine acetyltransferase 2B. (731 aa) |
| | ENSMFAP00000022083 | Uncharacterized protein. (134 aa) |
| | LPIN1 | Lipin 1. (975 aa) |
| | KL | Klotho peptide; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). (1014 aa) |
| | LOC102115428 | ANK_REP_REGION domain-containing protein. (278 aa) |
| | RAB8A | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | AGRP | Agouti related neuropeptide. (132 aa) |
| | HADH | Uncharacterized protein. (390 aa) |
| | ENSMFAP00000020785 | ANK_REP_REGION domain-containing protein. (366 aa) |
| | FBP1 | Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (341 aa) |
| | PTPN1 | Tyrosine-protein phosphatase non-receptor type. (435 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (338 aa) |
| | SOGA1 | Suppressor of glucose, autophagy associated 1. (1661 aa) |
| | SLC27A4 | Long-chain fatty acid transport protein 4; Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity); [...] (649 aa) |
| | SRC | Tyrosine-protein kinase. (542 aa) |
| | TRPV4 | Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (823 aa) |
| | SLC2A1 | Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa) |
| | GRB14 | Growth factor receptor bound protein 14. (540 aa) |
| | SYAP1 | Synapse associated protein 1. (407 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | PPARA | Peroxisome proliferator activated receptor alpha. (467 aa) |
| | EIF6 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa) |
| | SORBS1 | Sorbin and SH3 domain containing 1. (1294 aa) |
| | ZNF106 | Zinc finger protein 106. (1882 aa) |
| | GHRHR | Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (393 aa) |
| | CAPN10 | Calpain-10; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin- stimulated glucose uptake (By similarity). (681 aa) |
| | SCAP | SREBF chaperone. (1279 aa) |
| | GCLC | Glutamate-cysteine ligase catalytic subunit. (637 aa) |
| | PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa) |
| | DENND4C | DENN domain containing 4C. (1958 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (510 aa) |
| | CPEB1 | Cytoplasmic polyadenylation element binding protein 1. (613 aa) |
| | SLC2A4 | Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (559 aa) |
| | INPP5K | Inositol polyphosphate-5-phosphatase K. (450 aa) |
| | SREBF1 | Sterol regulatory element binding transcription factor 1. (1177 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa) |
| | EPM2AIP1 | EPM2A interacting protein 1. (607 aa) |
| | GCNT1 | Glucosaminyl (N-acetyl) transferase 1. (428 aa) |
| | CSRP3 | Cysteine and glycine rich protein 3. (194 aa) |
| | HDAC9 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa) |
| | TSC1 | TSC complex subunit 1. (1168 aa) |
| | CPEB2 | Cytoplasmic polyadenylation element binding protein 2. (883 aa) |
| | ENSMFAP00000010204 | ANK_REP_REGION domain-containing protein. (270 aa) |
| | RB1 | RB transcriptional corepressor 1. (928 aa) |
| | PDK4 | Protein-serine/threonine kinase. (411 aa) |
| | APPL1 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (715 aa) |
| | VPS13C | Vacuolar protein sorting 13 homolog C. (3754 aa) |
| | UCP3 | Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa) |
| | SELENOS | Selenoprotein S. (211 aa) |
| | EIF4EBP2 | Eukaryotic translation initiation factor 4E binding protein 2. (120 aa) |
| | RAB13 | Uncharacterized protein. (203 aa) |
| | PNPLA3 | Patatin like phospholipase domain containing 3. (507 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa) |
| | OTC | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa) |
| | GRB10 | Growth factor receptor bound protein 10. (593 aa) |
| | KLF15 | Kruppel like factor 15. (416 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | SRSF5 | Serine and arginine rich splicing factor 5. (272 aa) |
| | PCSK9 | Proprotein convertase subtilisin/kexin type 9. (811 aa) |
| | ENSMFAP00000005021 | Uncharacterized protein. (109 aa) |
| | LOC102126088 | ANK_REP_REGION domain-containing protein. (584 aa) |
| | OGT | O-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa) |
| | GAL | Galanin and GMAP prepropeptide. (143 aa) |
| | ENSMFAP00000004186 | Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (681 aa) |
| | RAB10 | RAB10, member RAS oncogene family. (200 aa) |
| | IDE | Insulin degrading enzyme; Belongs to the peptidase M16 family. (1021 aa) |
| | SLC22A12 | MFS domain-containing protein. (553 aa) |
| | ADM | Adrenomedullin. (185 aa) |
| | STXBP4 | Syntaxin binding protein 4. (555 aa) |
| | MAX | BHLH domain-containing protein. (160 aa) |
| | SLC2A8 | Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa) |
| | LPIN3 | Lipin 3. (852 aa) |
| | XBP1 | BZIP domain-containing protein. (380 aa) |
| | GRB2 | Growth factor receptor-binding protein 2. (217 aa) |
| | WDTC1 | WD and tetratricopeptide repeats 1. (687 aa) |
| | BCAR1 | BCAR1 scaffold protein, Cas family member. (916 aa) |
| | TRIB3 | Tribbles pseudokinase 3. (385 aa) |
| | SLC25A33 | Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (289 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | STXBP3 | Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa) |
| | CCDC144NL | Uncharacterized protein. (1391 aa) |
| | TRARG1 | Trafficking regulator of GLUT4 (SLC2A4) 1. (177 aa) |
| | ADIPOQ | Adiponectin, C1Q and collagen domain containing. (274 aa) |
| | ENSMFAP00000045074 | Uncharacterized protein. (128 aa) |
| | SLC29A2 | Solute carrier family 29 member 2. (462 aa) |
| | SESN3 | Uncharacterized protein. (530 aa) |
| | VGF | VGF nerve growth factor inducible. (615 aa) |
| | USF1 | Upstream transcription factor 1. (310 aa) |
| | IRS1 | Insulin receptor substrate 1. (1241 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | PHIP | Pleckstrin homology domain interacting protein. (1796 aa) |
| | HADHA | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa) |
| | POU4F2 | POU domain protein. (408 aa) |
| | APC | APC regulator of WNT signaling pathway. (2861 aa) |
| | HSD11B2 | Hydroxysteroid 11-beta dehydrogenase 2. (379 aa) |
| | CRY1 | Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...] (586 aa) |
| | GSK3A | Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa) |
| | SIRT1 | Sirtuin 1. (743 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. (925 aa) |
| | INSRR | Tyrosine-protein kinase receptor. (1301 aa) |
| | RAB31 | RAB31, member RAS oncogene family. (194 aa) |
| | RETN | Uncharacterized protein. (65 aa) |
| | GHSR | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa) |
| | CYFIP1 | Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1232 aa) |
| | LPIN2 | Lipin 2. (933 aa) |
| | INSIG1 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (660 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1382 aa) |
| | PKLR | Pyruvate kinase; Belongs to the pyruvate kinase family. (574 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (583 aa) |
| | ENSMFAP00000037410 | Uncharacterized protein. (137 aa) |
| | INPPL1 | Inositol polyphosphate phosphatase like 1. (1264 aa) |
| | SLC9A1 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa) |
| | C2CD5 | C2 calcium dependent domain containing 5. (1084 aa) |
| | SLC27A1 | Solute carrier family 27 member 1. (646 aa) |
| | PIK3R2 | Uncharacterized protein. (694 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa) |
| | IRS4 | Insulin receptor substrate 4. (1222 aa) |
| | MEAK7 | MTOR associated protein, eak-7 homolog. (501 aa) |
| | FOXC2 | Forkhead box C2. (487 aa) |
| | IGFBP1 | Insulin like growth factor binding protein 1. (281 aa) |
| | ENSMFAP00000034846 | Uncharacterized protein. (131 aa) |
| | EEF2K | Eukaryotic elongation factor 2 kinase. (725 aa) |
| | APRT | Adenine phosphoribosyltransferase. (206 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | SLC39A14 | Solute carrier family 39 member 14. (490 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa) |
| | AP3S1 | Adaptor related protein complex 3 subunit sigma 1. (193 aa) |
| | LOC102140528 | Uncharacterized protein. (938 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1367 aa) |
| | STAT1 | Signal transducer and activator of transcription. (758 aa) |
| | CEACAM1 | Uncharacterized protein. (525 aa) |
| | SRSF6 | Serine and arginine rich splicing factor 6. (343 aa) |
| | MYO5A | Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1855 aa) |
| | ZDHHC7 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (336 aa) |
| | PDK2 | Protein-serine/threonine kinase. (568 aa) |
| | FER | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | IRS2 | Insulin receptor substrate 2. (1279 aa) |
| | ACVR1C | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (488 aa) |
| | ZBTB7B | Zinc finger and BTB domain containing 7B. (573 aa) |
| | EPRS1 | Glutamyl-prolyl-tRNA synthetase. (1512 aa) |
| | GPT | Glutamic--pyruvic transaminase. (496 aa) |
| | SRSF4 | Serine and arginine rich splicing factor 4. (494 aa) |
| | TBC1D4 | TBC1 domain family member 4. (1298 aa) |
| | GPLD1 | Glycosylphosphatidylinositol specific phospholipase D1. (841 aa) |
| | BCAR3 | Breast cancer anti-estrogen resistance protein 3 homolog; Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (By similarity). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and [...] (823 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | PLA2G1B | Phospholipase A(2). (148 aa) |
| | SP1 | Sp1 transcription factor. (786 aa) |
| | CRY2 | Cryptochrome circadian regulator 2. (614 aa) |
| | OBP2B | Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (141 aa) |
| | KBTBD2 | Kelch repeat and BTB domain containing 2. (623 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | RAB15 | RAB15, member RAS oncogene family. (212 aa) |
| | RHOQ | Ras homolog family member Q. (205 aa) |
| | IGF2 | Insulin like growth factor 2. (183 aa) |
| | ERRFI1 | ERBB receptor feedback inhibitor 1. (462 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (415 aa) |
| | FOXO1 | Forkhead box O1. (655 aa) |
| | OTOP1 | Otopetrin 1. (610 aa) |
| | KCNQ1 | Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (644 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa) |
| | GAB1 | GRB2 associated binding protein 1. (751 aa) |
| | CITED1 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa) |
| | GCK | Phosphotransferase. (480 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | PDE3B | Phosphodiesterase. (1117 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (622 aa) |
| | HMGCS2 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa) |
| | SORT1 | Sortilin. (831 aa) |
| | NCOA5 | Nuclear receptor coactivator 5. (584 aa) |
| | RAB12 | RAB12, member RAS oncogene family. (246 aa) |
