STRINGSTRING
HSPA6 HSPA6 DNAJC3 DNAJC3 UGGT1 UGGT1 HERPUD1 HERPUD1 EDEM2 EDEM2 UBE2J2 UBE2J2 COMP COMP HSPB2 HSPB2 HSPA4L HSPA4L RHBDD2 RHBDD2 UBXN4 UBXN4 ABCB10 ABCB10 DNAJC4 DNAJC4 CUL3 CUL3 UBE2W UBE2W TMEM129 TMEM129 ERP27 ERP27 ATF4 ATF4 EP300 EP300 ENSMFAP00000043889 ENSMFAP00000043889 WFS1 WFS1 ERN1 ERN1 ENSMFAP00000042652 ENSMFAP00000042652 CREB3L3 CREB3L3 HSPA5 HSPA5 PACRG PACRG TMBIM6 TMBIM6 TM7SF3 TM7SF3 DNAJB2 DNAJB2 NFE2L2 NFE2L2 CDK5RAP3 CDK5RAP3 TBL2 TBL2 HSPB3 HSPB3 HSF1 HSF1 ENSMFAP00000015333 ENSMFAP00000015333 CREB3L4 CREB3L4 RHBDD1 RHBDD1 CREB3L1 CREB3L1 EIF2AK3 EIF2AK3 FGF21 FGF21 MBTPS1 MBTPS1 EDEM3 EDEM3 DNAJB5 DNAJB5 F12 F12 ERLEC1 ERLEC1 ENSMFAP00000020087 ENSMFAP00000020087 THBS1 THBS1 PTPN1 PTPN1 RNF5 RNF5 SDF2L1 SDF2L1 THBS4 THBS4 ATF3 ATF3 CREB3L2 CREB3L2 BAG3 BAG3 ENSMFAP00000022286 ENSMFAP00000022286 HSPA2 HSPA2 ENSMFAP00000022974 ENSMFAP00000022974 DNAJB12 DNAJB12 FBXO6 FBXO6 CHAC1 CHAC1 UGGT2 UGGT2 TMTC4 TMTC4 HDAC6 HDAC6 MANF MANF ATXN3 ATXN3 DERL1 DERL1 CREB3 CREB3 LOC102147033 LOC102147033 MFN2 MFN2 DDIT3 DDIT3 HERPUD2 HERPUD2 HSPB1 HSPB1 OPTN OPTN UMOD UMOD CREBZF CREBZF PMP22 PMP22 CLU CLU STT3B STT3B ENSMFAP00000029034 ENSMFAP00000029034 AMFR AMFR STUB1 STUB1 DERL2 DERL2 DNAJB1 DNAJB1 DAB2IP DAB2IP UFD1 UFD1 DNAJC18 DNAJC18 OS9 OS9 BAG6 BAG6 AUP1 AUP1 PRKN PRKN DNAJB9 DNAJB9 TRAM1 TRAM1 EDEM1 EDEM1 CREBRF CREBRF ERN2 ERN2 PARP16 PARP16 ATF6B ATF6B DERL3 DERL3 JKAMP JKAMP SELENOS SELENOS RNF126 RNF126 ERO1A ERO1A HSPB8 HSPB8 ERMP1 ERMP1 HSPB7 HSPB7 G7PJL0_MACFA G7PJL0_MACFA ENSMFAP00000011787 ENSMFAP00000011787 CASP12 CASP12 ENSMFAP00000012410 ENSMFAP00000012410 AKIRIN2 AKIRIN2 BAK1 BAK1 VCP VCP PACRGL PACRGL QRICH1 QRICH1 YOD1 YOD1 CCND1 CCND1 TMED2 TMED2 ENSMFAP00000001570 ENSMFAP00000001570 XBP1 XBP1 EIF2AK2 EIF2AK2 FAF2 FAF2 TOR1B TOR1B ATF6 ATF6 ERP44 ERP44 CLUL1 CLUL1 DAXX DAXX TOR1A TOR1A KLHL15 KLHL15 EIF2S1 EIF2S1 FICD FICD VAPB VAPB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (600 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
UGGT1UDP-glucose glycoprotein glucosyltransferase 1. (1556 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (391 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa)
UBE2J2Ubiquitin conjugating enzyme E2 J2. (273 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
HSPB2SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (182 aa)
HSPA4LHeat shock protein family A (Hsp70) member 4 like. (840 aa)
RHBDD2Rhomboid domain containing 2. (364 aa)
UBXN4UBX domain protein 4. (508 aa)
ABCB10ATP binding cassette subfamily B member 10. (738 aa)
DNAJC4DnaJ heat shock protein family (Hsp40) member C4. (244 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
UBE2WUBIQUITIN_CONJUGAT_2 domain-containing protein. (191 aa)
TMEM129Transmembrane protein 129. (357 aa)
ERP27Endoplasmic reticulum protein 27. (273 aa)
ATF4Activating transcription factor 4. (351 aa)
EP300E1A binding protein p300. (2414 aa)
ENSMFAP00000043889Uncharacterized protein; Belongs to the heat shock protein 70 family. (619 aa)
WFS1Wolframin ER transmembrane glycoprotein. (890 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (978 aa)
ENSMFAP00000042652Uncharacterized protein; Belongs to the GroES chaperonin family. (95 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (301 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
PACRGParkin coregulated. (296 aa)
TMBIM6Uncharacterized protein; Belongs to the BI1 family. (267 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
DNAJB2J domain-containing protein. (324 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (541 aa)
TBL2Transducin beta like 2. (446 aa)
HSPB3Heat shock protein family B (small) member 3; Belongs to the small heat shock protein (HSP20) family. (150 aa)
HSF1Heat shock transcription factor 1. (529 aa)
ENSMFAP00000015333Uncharacterized protein. (293 aa)
CREB3L4Processed cyclic AMP-responsive element-binding protein 3-like protein 4; Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). (422 aa)
RHBDD1Rhomboid domain containing 1. (316 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
MBTPS1Membrane bound transcription factor peptidase, site 1. (1054 aa)
EDEM3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (948 aa)
DNAJB5DnaJ heat shock protein family (Hsp40) member B5. (462 aa)
F12Coagulation factor XII. (615 aa)
ERLEC1Endoplasmic reticulum lectin 1. (483 aa)
ENSMFAP00000020087Josephin domain-containing protein. (314 aa)
THBS1Thrombospondin 1. (1173 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
RNF5Ring finger protein 5. (180 aa)
SDF2L1Stromal cell derived factor 2 like 1. (221 aa)
THBS4Thrombospondin 4. (961 aa)
ATF3Activating transcription factor 3. (181 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
BAG3BCL2 associated athanogene 3. (575 aa)
ENSMFAP00000022286Uncharacterized protein. (156 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (641 aa)
ENSMFAP00000022974DnaJ_C domain-containing protein. (213 aa)
DNAJB12DnaJ heat shock protein family (Hsp40) member B12. (409 aa)
FBXO6F-box protein 6. (293 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (264 aa)
UGGT2UDP-glucose glycoprotein glucosyltransferase 2. (1518 aa)
TMTC4Transmembrane O-mannosyltransferase targeting cadherins 4. (867 aa)
HDAC6Histone deacetylase 6. (1215 aa)
MANFMesencephalic astrocyte derived neurotrophic factor. (182 aa)
ATXN3Josephin domain-containing protein. (375 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
LOC102147033Uncharacterized protein; Belongs to the GroES chaperonin family. (108 aa)
MFN2Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
HERPUD2Ubiquitin-like domain-containing protein. (406 aa)
HSPB1SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
OPTNOptineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (571 aa)
UMODUromodulin. (641 aa)
CREBZFCREB/ATF bZIP transcription factor. (357 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
CLUClusterin; Belongs to the clusterin family. (501 aa)
STT3BSTT3 oligosaccharyltransferase complex catalytic subunit B. (825 aa)
ENSMFAP00000029034Uncharacterized protein; Belongs to the GroES chaperonin family. (88 aa)
AMFRAutocrine motility factor receptor. (643 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
DNAJB1DnaJ heat shock protein family (Hsp40) member B1. (340 aa)
DAB2IPDAB2 interacting protein. (1153 aa)
UFD1Ubiquitin recognition factor in ER associated degradation 1. (308 aa)
DNAJC18DnaJ homolog subfamily C member 18. (358 aa)
OS9OS9 endoplasmic reticulum lectin. (716 aa)
BAG6BCL2 associated athanogene 6. (1132 aa)
AUP1AUP1 lipid droplet regulating VLDL assembly factor. (410 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
DNAJB9J domain-containing protein. (222 aa)
TRAM1Translocating chain-associated membrane protein; Belongs to the TRAM family. (374 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (657 aa)
CREBRFBZIP domain-containing protein. (642 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (767 aa)
PARP16Poly [ADP-ribose] polymerase. (477 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (238 aa)
JKAMPJNK1/MAPK8 associated membrane protein. (325 aa)
SELENOSSelenoprotein S. (211 aa)
RNF126Ring finger protein 126. (311 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (196 aa)
ERMP1Endoplasmic reticulum metallopeptidase 1. (1055 aa)
HSPB7Heat shock protein family B (small) member 7; Belongs to the small heat shock protein (HSP20) family. (249 aa)
G7PJL0_MACFAUncharacterized protein; Belongs to the GroES chaperonin family. (102 aa)
ENSMFAP00000011787Uncharacterized protein; Belongs to the BI1 family. (190 aa)
CASP12Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (408 aa)
ENSMFAP00000012410Uncharacterized protein; Belongs to the GroES chaperonin family. (102 aa)
AKIRIN2Akirin 2. (205 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
PACRGLParkin coregulated like. (248 aa)
QRICH1Glutamine rich 1. (777 aa)
YOD1YOD1 deubiquitinase. (348 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
TMED2GOLD domain-containing protein. (208 aa)
ENSMFAP00000001570GOLD domain-containing protein. (188 aa)
XBP1BZIP domain-containing protein. (380 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (554 aa)
FAF2Fas associated factor family member 2. (445 aa)
TOR1BTorsin. (336 aa)
ATF6Activating transcription factor 6. (669 aa)
ERP44Thioredoxin domain-containing protein. (414 aa)
CLUL1Clusterin; Belongs to the clusterin family. (491 aa)
DAXXDeath domain associated protein. (740 aa)
TOR1ATorsin-1A; Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular traffickin [...] (315 aa)
KLHL15Kelch like family member 15. (604 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
FICDFIC domain containing. (460 aa)
VAPBVesicle-associated membrane protein-associated protein B. (243 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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